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Film coating agent for treating acute and sub-acute eczema

A subacute and film-coating technology, applied in the direction of non-central analgesics, anti-inflammatory agents, medical preparations containing active ingredients, etc., can solve difficult to cure, bacterial infection and other problems, achieve long-lasting drug effect, easy to accept , no dressing effect

Inactive Publication Date: 2018-02-06
CHENGDU SHENGSHI GUANGHUA BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Many clinical treatments are still difficult to cure
At present, symptomatic treatment is mostly used clinically, and there are bacterial infections that cannot be ignored in the treatment, especially the lesion site has affinity for Staphylococcus aureus

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0026] The coating agent for treating acute and subacute eczema of the present embodiment is expressed by weight and consists of 20 g of loratadine, 10 g of cetirizine, 4 g of chitosan, 1 g of arbutin, and 800 g of ethanol.

[0027] The preparation method of above-mentioned compound treatment acute, subacute eczema coating agent, comprises the following steps:

[0028] (1) Add 20g of loratadine and 10g of cetirizine to 250g of ethanol, stir and dissolve with a magnetic stirrer, and obtain a mixed solution for use;

[0029] (2) Sprinkle 4g ​​of chitosan evenly to make it swell naturally;

[0030] (3) Add 1.0g arbutin, put it in a 1200ml large beaker, keep stirring, and add ethanol to 1000mL;

[0031] (4) Use a pH regulator to adjust the pH to 6.0~7.0, stir well, and then it can be used to treat acute and subacute eczema.

[0032] When the solution is acidic, use a mass fraction of 85% sodium carbonate solution as a pH regulator, and when the solution is alkaline, use a mass f...

Embodiment 2

[0035] In the above example, this embodiment is further expressed by weight, and the loratadine is 20 g, cetirizine 10 g, chitosan 4 g, arbutin 1 g, and ethanol 800 g. Other steps in this embodiment are the same as those in the above embodiment, and will not be repeated here.

Embodiment 3

[0037] In this embodiment, in the above embodiment, further, the viscosity of the chitosan is 50 mPa·s, and the degree of deacetylation is not less than 80%. Other steps in this embodiment are the same as those in the above embodiment, and will not be repeated here.

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Abstract

The invention discloses a coating agent for treating acute and subacute eczema, expressed by weight, consisting of 15-42 g of loratadine, 7-23 g of cetirizine, 2-8 g of chitosan, and bearberry Glycoside 0.5~2.1g, ethanol 500~900g composition. In the present invention, loratadine and cetirizine have obvious effects on inhibiting bacteria, and loratadine and cetirizine are prepared into medicines. Due to the transdermal technology of arbutin, the penetrating power of medicine skin limbs has been increased. , showing the superior curative effect of the coating agent on chronic eczema; the medicine for treating acute and subacute eczema made of chitosan has no greasy feeling, is easy to spread, has strong adhesion, and has a certain tear resistance. Convenient and non-irritating to the skin.

Description

technical field [0001] The invention relates to the field of coating agent preparation, in particular to a coating agent for treating acute and subacute eczema. Background technique [0002] Eczema is a skin inflammatory reaction caused by complex internal and external factors. Chronic eczema is generally limited and has infiltration and hypertrophy, severe itching, and easy recurrence. The etiology of the disease is complex, and internal and external factors interact, often in many ways. Patients often have allergic constitution, which is related to genetic factors, so it occurs in specific groups of people. [0003] Acute eczema is an inflammatory skin disease of the epidermis and superficial dermis caused by a variety of internal and external factors. It has a variety of rashes and exudation tendencies, accompanied by severe itching, and is prone to repeated attacks. It is often related to allergic reactions. In the early or acute stage, the clinical symptoms are patch...

Claims

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Application Information

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IPC IPC(8): A61K31/4545A61K31/495A61K31/045A61P17/00A61P29/00A61K9/70A61K9/00A61K47/26A61K47/36
CPCA61K31/4545A61K9/0014A61K9/7015A61K31/045A61K31/495A61K47/26A61K47/36A61K2300/00
Inventor 张蛟
Owner CHENGDU SHENGSHI GUANGHUA BIOTECH CO LTD
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