A kind of cross-linked sodium alginate hydrogel and its preparation method and application

A technology of sodium alginate and hydrogel, which is applied in the direction of botany equipment and methods, applications, biocides, etc., can solve the problems of limiting the water absorption and swelling effect of the gel, and the reduction of swelling property, so as to improve the sustained release performance of drugs , good swelling performance and enhanced sustained release effect

Active Publication Date: 2019-12-10
HAINAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the compound interpenetrating network structure of the gel, the swelling property of sodium alginate is slightly reduced, and it has a better controlled release effect on the drug; however, adding mineral montmorillonite to the network structure of the hydrogel, due to the The lamellar structure of desoiling runs through the gel network structure, thus limiting the water absorption and swelling effect of the gel, and has a better controlled release effect on the active ingredients of pesticides

Method used

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  • A kind of cross-linked sodium alginate hydrogel and its preparation method and application
  • A kind of cross-linked sodium alginate hydrogel and its preparation method and application
  • A kind of cross-linked sodium alginate hydrogel and its preparation method and application

Examples

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Embodiment 1

[0039] A cross-linked sodium alginate hydrogel comprises the following components: acrylamide, sodium montmorillonite, sodium alginate, initiator, cross-linking agent, catalyst, calcium sulfate, and deionized water.

[0040] In parts by mass, every 100 parts of the cross-linked sodium alginate hydrogel contains 10 parts of acrylamide, 2.5 parts of sodium montmorillonite, 1 part of sodium alginate and 0.1 part of calcium sulfate.

[0041] The initiator is ammonium persulfate, the crosslinking agent is N,N'-methylenebisacrylamide, and the catalyst is tetramethylethylenediamine; the content of each component is 0.1 based on the mass of acrylamide content. % ammonium persulfate (APS), 0.06% N,N'-methylenebisacrylamide, 0.2485% tetramethylethylenediamine.

[0042] The preparation method of above-mentioned cross-linked sodium alginate hydrogel comprises the following steps:

[0043] (1) Take 10g of acrylamide in a 150ml three-necked flask, add about 60g of deionized water and mecha...

Embodiment 2

[0048] A cross-linked sodium alginate hydrogel comprises the following components: acrylamide, sodium montmorillonite, sodium alginate, initiator, cross-linking agent, catalyst, calcium sulfate, and deionized water.

[0049] In parts by mass, every 100 parts of the crosslinked sodium alginate hydrogel contains 12 parts of acrylamide, 8 parts of sodium montmorillonite, 2 parts of sodium alginate and 0.2 part of calcium sulfate.

[0050] The initiator is ammonium persulfate, the crosslinking agent is N,N'-methylenebisacrylamide, and the catalyst is tetramethylethylenediamine; the content of each component is 0.1 based on the mass of acrylamide content. % ammonium persulfate (APS), 0.06% N,N'-methylenebisacrylamide, 0.2485% tetramethylethylenediamine.

[0051] The preparation method of above-mentioned cross-linked sodium alginate hydrogel comprises the following steps:

[0052] (1) Take 12g of acrylamide in a 150ml three-neck flask, add about 60g of deionized water and mechanica...

Embodiment 3

[0057] A cross-linked sodium alginate hydrogel comprises the following components: acrylamide, sodium montmorillonite, sodium alginate, initiator, cross-linking agent, catalyst, calcium sulfate, and deionized water.

[0058] In parts by mass, every 100 parts of the cross-linked sodium alginate hydrogel contains 11 parts of acrylamide, 10 parts of sodium montmorillonite, 3 parts of sodium alginate and 0.3 parts of calcium sulfate.

[0059] The initiator is ammonium persulfate, the crosslinking agent is N,N'-methylenebisacrylamide, and the catalyst is tetramethylethylenediamine; the content of each component is 0.1 based on the mass of acrylamide content. % ammonium persulfate (APS), 0.06% N,N'-methylenebisacrylamide, 0.2485% tetramethylethylenediamine.

[0060] The preparation method of above-mentioned cross-linked sodium alginate hydrogel comprises the following steps:

[0061] (1) Take 11g of acrylamide in a 150ml three-necked flask, add about 60g of deionized water and mech...

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Abstract

The invention relates to the field of sustained release of pesticides, and discloses crosslinked sodium alginate hydrogel as well as a preparation method and application thereof. According to the preparation method, sodium alginate and polyacrylamide are taken as main raw materials, and the crosslinked sodium alginate hydrogel is prepared by compounding Na-montmorillonite. The invention also discloses the preparation method of the crosslinked sodium alginate hydrogel and the application of the crosslinked sodium alginate hydrogel in the sustained release of the pesticides. The crosslinked sodium alginate hydrogel prepared by the method provided by the invention has a reticular structure; the Na-montmorillonite is distributed in the reticular structure of gel in a lamellar structure and interacts with a polymer chain of the gel, so that the swelling action of the gel in water is limited; furthermore, under the compound effect of the Na-montmorillonite, the reticular structure of the gelis enabled to be more complicated, and the outward diffusion of drugs in the reticular structure of the gel is diminished, so that the sustained release effect is enhanced.

Description

technical field [0001] The invention relates to the field of sustained release of pesticides, in particular to a cross-linked sodium alginate hydrogel and its preparation method and application. Background technique [0002] Acetamiprid is widely used in the field of pesticides, but its large amount of use leads to serious residues in the environment, causing serious pollution to the environment. [0003] In order to solve these problems, improve the utilization rate of pesticides and their continuous effective time, use drug-loaded controlled / slow-release carriers to control the release of pesticides, reduce the amount of pesticides used, and achieve the purpose of a small amount of high efficiency. Hydrogels have been widely used in the field of controlled drug release. Hydrogels are prepared with natural polymer polysaccharides as the basic material. The gels have good biodegradability, are non-toxic to the environment, and have good controlled release of pesticide activ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F251/00C08F220/56C08J3/075C08K3/34C08K3/30A01N25/10A01N25/08A01N47/40
CPCA01N25/08A01N25/10A01N47/40C08F251/00C08J3/075C08J2351/02C08K3/30C08K3/346C08K2003/3045C08F220/56
Inventor 李嘉诚冯玉红余高波周庆丰
Owner HAINAN UNIV
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