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Pharmaceutical application of a polypeptide in the prevention or treatment of diseases related to acute lung injury

A technology for acute lung injury and disease, which is applied in the field of drug application of peptides in the prevention or treatment of acute lung injury-related diseases, can solve problems such as lack of prevention and treatment drugs, and achieve the effect of wide clinical application value.

Active Publication Date: 2020-07-31
GUANGDONG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although some drugs are currently being developed, there is still a lack of preventive drugs that can achieve satisfactory results (for example, see "Research Progress in Drug Therapy for Acute Lung Injury" (Chen Xiaoming, Zhao Hang; Medical Theory and Practice 2017 No. 19, No. 2836-2838); or refer to "Research Progress of Endotoxin-Induced Acute Lung Injury Treatment Drugs" (Yu Ziru, Du Guanhua; China New Drugs 2017 No. 13, pp. 1510-1555), therefore, further research and development of ALI and New drugs for the prevention or treatment of lung injury-related diseases such as ARDS have very important practical significance

Method used

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  • Pharmaceutical application of a polypeptide in the prevention or treatment of diseases related to acute lung injury
  • Pharmaceutical application of a polypeptide in the prevention or treatment of diseases related to acute lung injury
  • Pharmaceutical application of a polypeptide in the prevention or treatment of diseases related to acute lung injury

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Embodiment Construction

[0008] In order to have a clearer understanding of the technical features, purposes and effects of the present invention, the specific implementation manners of the present invention will now be described with reference to the accompanying drawings. The following specific examples are only used to illustrate the present invention and are not intended to limit the scope of the present invention.

[0009] The present inventors previously isolated a polypeptide-AdKI4 from Ancylostoma duodenale. Through a series of exploratory studies, the inventors used lipopolysaccharide (LPS) to induce mice to establish an acute lung injury model, and first confirmed that AdKI4 has a significant protective effect on acute lung injury. Therefore, AdKI4 can be used as a drug to prevent or treat acute lung injury-related disease.

[0010] The protective effect of example rAdKI4 on acute lung injury

[0011] 1 Experimental materials

[0012] The complete amino acid sequence of AdKI4 obtained by ...

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Abstract

The invention discloses a drug application of polypeptide to prevention or treatment of ALI (acute lung injury) related diseases and belongs to the field of biomedicine. The amino acid sequence of thepolypeptide is shown as SEQ ID NO.1 or SEQ ID NO.2. The polypeptide has an obvious protective effect on ALI, can serve as a drug for preventing or treating the ALI (acute lung injury) related diseases and has clinical application value.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to the pharmaceutical application of a polypeptide in the prevention or treatment of diseases related to acute lung injury. Background technique [0002] Acute lung injury (ALI) and its severe state-acute respiratory distress syndrome (ARDS) is a common clinical emergency and severe disease, which seriously threatens the life of patients and affects their quality of life, with a mortality rate as high as 35%. % to 60%, bringing a heavy burden to society and patients' families. At present, the main measure for the treatment of such diseases is mechanical ventilation. In addition, glucocorticoids and anti-inflammatory drugs also have certain curative effects. Although some drugs are currently being developed, there is still a lack of preventive drugs that can achieve satisfactory results (for example, see "Research Progress in Drug Therapy for Acute Lung Injury" (Chen Xiaoming, Zhao Hang; ...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/17A61P11/00
CPCA61K38/1767
Inventor 彭礼飞罗辉司徒永立邵正邓莉何庆丰廖淑莉
Owner GUANGDONG MEDICAL UNIV