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Composite traditional Chinese medicine fermented substance for improving immunity effect of chicken vaccine

A compound traditional Chinese medicine and immune effect technology, which is applied in the direction of drug combination, medical formula, plant raw materials, etc., can solve the problems of chicken immune response barriers and other problems, and achieve the effect of rich drug sources, short immunization time, and no drug residues

Inactive Publication Date: 2018-03-06
BEIJING DAWEIJIA BIOTECH SHARE CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve the problem of immune response disorder in chickens, the invention provides a fermented product of compound traditional Chinese medicine for improving the immune effect of chicken vaccines for improving the immune effect of chicken vaccines

Method used

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  • Composite traditional Chinese medicine fermented substance for improving immunity effect of chicken vaccine
  • Composite traditional Chinese medicine fermented substance for improving immunity effect of chicken vaccine
  • Composite traditional Chinese medicine fermented substance for improving immunity effect of chicken vaccine

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach 1

[0023] Specific embodiment 1 The distribution ratio of each component in the fermented product of traditional Chinese medicine

[0024] Formula 1: Astragalus 30kg, Codonopsis 30kg, Ligustrum lucidum 30kg, Polygonum cuspidatum 10kg, Yeast 3kg.

[0025] Formula 2: Astragalus 40kg, Codonopsis 25kg, Ligustrum lucidum 20kg, Polygonum cuspidatum 15kg, Lactobacillus bulgaricus 1kg, yeast 1kg.

[0026] Formula 3: Astragalus 50kg, Codonopsis 20kg, Ligustrum lucidum 15kg, Polygonum cuspidatum 15kg, Bifidobacterium 2kg, Lactobacillus casei 2kg.

[0027] Formula 4: Astragalus 40kg, Codonopsis 20kg, Ligustrum lucidum 25kg, Polygonum cuspidatum 15kg, Bifidobacterium 2kg, Lactobacillus casei 2kg.

[0028] Formula 5: Astragalus 30kg, Codonopsis 20kg, Ligustrum lucidum 30kg, Polygonum cuspidatum 20kg, Bifidobacterium 2kg, Lactobacillus casei 3kg.

specific Embodiment approach 2

[0029] Specific embodiment 2 Preparation of different dosage forms of traditional Chinese medicine composition

[0030] Powder preparation method: Weigh various raw medicinal materials according to the formula ratio, crush them through a 40-mesh sieve with a pulverizer, mix them evenly, add them to a fermenter, spray 70% of water, heat to 100°C for 60 minutes to sterilize, and then cool to 37°C, add suitable strains, stir and mix evenly, keep the temperature at 37°C, relative humidity 70%, and ferment in airtight for 3 days, take out and dry at 40°C until the water content is 5-8%, crush and pass through an 80-mesh sieve, pour Seal it and get it.

[0031] Oral liquid preparation method: Weigh various raw medicinal materials according to the formula ratio, crush them through a 40-mesh sieve with a pulverizer, mix them evenly, add them to a fermenter, spray 70% of water, and then heat to 100°C for 60 minutes to sterilize, then Cool to 37°C, add suitable strains, stir and mix ev...

specific Embodiment approach 3

[0033] Specific implementation mode 3: Pharmacodynamic research

[0034] Laboratory efficacy evaluation test of immune booster:

[0035] The oral liquid of the Chinese medicine fermented product prepared in test drug example 1.

[0036] Main test reagents: Newcastle disease live vaccine (VH strain), Newcastle disease antigen (LaSota), 1% young chicken red blood cell suspension (RBC), Alfred's solution (ACD), phosphate buffer saline (PBS).

[0037] Test treatment

[0038] 400 white-feathered broiler chicks without maternal antibodies to Newcastle disease were randomly divided into 4 groups, 100 in each group. Namely negative control group, 0.2ml / sample in high dose group, 0.4ml / sample in middle dose group, 0.6ml / sample in high dose group, two replicates for each group. At the age of 7 days, intranasal eye drops were administered once a day. Started 3 days before the vaccine immunization, and administered continuously for 5 days. At the age of 6 days, 11 days, 14 days, 20 d...

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Abstract

The invention relates to a composite traditional Chinese medicine fermented substance for improving immunity effects of chicken vaccines. The fermented substance is a preparation prepared from the following medicinal materials through microorganism fermentation: 30-50% of astragalus membranaceus, 20-30% of codonopsis pilosula, 10-30% of glossy privet fruits and 10-20% of polygonum cuspidatum. Thefermented substance is scientific in formula, rich in medicine source, low in cost, simple in production process and controllable in quality. A great amount of clinical tests show that the immunity effects of vaccines can be effectively improved; after the fermented substance is inoculated with the vaccines, short immunity achieving time, good antibody uniformity and long maintenance time are achieved; as a pure traditional Chinese medicine preparation, the fermented substance is free of withdrawal time or medicine residue, and animal food security can be ensured; meanwhile, due to a fermentation production process, not only are medicinal effects improved, but also waste of traditional Chinese medicine resources is reduced; meanwhile according to production conditions and market requirements, the composite traditional Chinese medicine fermented substance can be prepared into various medicine dosage forms such as powder, granules and oral liquids.

Description

technical field [0001] The invention belongs to the field of veterinary medicine preparations. In particular, it relates to a compound traditional Chinese medicine fermented product for improving the immune effect of chicken vaccines. Background technique [0002] At present, under the highly intensive breeding mode, the prevention and control of chicken viral diseases is often better than cure, and the main means of preventing viral diseases is vaccination, so that chickens can obtain passive immunity to defend against viruses. invasion. However, in actual production, it is often due to various factors such as vaccine quality, immunization procedures, immunization pathways, especially the immune response of chickens, etc. that cause poor immunization effects in chicken flocks. Low antibody titers and poor uniformity have caused many viral infections in recent years. The prevalence of the disease presents new features: new strains emerge continuously, often making chickens...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/704A61K39/39A61P37/04A61K35/747
CPCA61K35/747A61K36/06A61K36/344A61K36/481A61K36/638A61K36/704A61K39/39A61K2300/00
Inventor 许丹赵宝凯王洪礼
Owner BEIJING DAWEIJIA BIOTECH SHARE CO LTD
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