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Preparation method for decreasing impurities of gentamicin sulfate

A technology of gentamicin sulfate and gentamicin, which is applied to the preparation of sugar derivatives, chemical instruments and methods, sugar derivatives, etc., can solve the problems of difficult compliance and high product impurities, and achieve easy operation of the production process, The effect of reducing impurities and simplifying the production process

Inactive Publication Date: 2018-03-09
福安药业集团烟台只楚药业有限公司
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Problems solved by technology

However, using the existing gentamicin production formula for fermentation and production, the product has high impurities, which is difficult to meet the requirements of the 2010 edition of the "Chinese Pharmacopoeia"

Method used

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Embodiment Construction

[0040] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the embodiments of the present invention. Apparently, the described embodiments are only some of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0041] In the embodiment of the present invention 1, a kind of gentamicin sulfate preparation method that can reduce impurity, it specifically comprises the following steps:

[0042] 1) Take gentamicin sandy soil spores and place them on spore slant medium for spore culture, the culture temperature is 36°C, and the culture time is 10 days, and the gentamicin spores after slant culture are obtained;

[0043] The preparation method of above-mentioned gentamicin sand spore is: ...

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Abstract

The invention discloses a preparation method of gentamicin sulfate capable of reducing impurities, which can significantly reduce the impurities of gentamicin sulfate products, meets the requirements of "Chinese Pharmacopoeia" (2015 edition), and the production process is simple and easy to operate; The present invention differs from the prior art in the following three points: 0.001% adenosine triphosphate and 0.001% glycine are added to the spore slant culture medium; 0.001% adenosine triphosphate and 0.001% glycine are added to the seed culture medium; 0.003% adenosine triphosphate is added to the fermentation medium and 0.003% glycine; the total miscellaneous content of the gentamicin sulfate product produced before the improvement > 4%, and sisomicin > 1.5%; Somicin <1.5%, Minor Normycin (Small Normicin) <3%.

Description

technical field [0001] The invention relates to the field of antibiotic fermentation, in particular to a preparation method of gentamicin sulfate capable of reducing impurities. Background technique [0002] Gentamicin sulfate is an aminoglycoside antibiotic, which has good antibacterial effect on various Gram-negative bacteria and Gram-positive bacteria, and has good antibacterial effect on various Enterobacteriaceae bacteria such as Escherichia coli, Klebsiella, Proteus Genus, Salmonella, Shigella, Enterobacter, Serratia and Pseudomonas aeruginosa have good antibacterial effect, Neisseria and Haemophilus influenzae are moderately sensitive to this product. It also has certain effects on Brucella, Yersinia pestis, Acinetobacter, and Campylobacter fetus. It has good antibacterial effect on about 80% of methicillin-sensitive strains in Staphylococcus (including Staphylococcus aureus and coagulase-negative staphylococcus), but most of the methicillin-resistant strains are res...

Claims

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Application Information

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IPC IPC(8): C12P19/48C07H15/236C07H1/06
CPCC12P19/48C07H1/06C07H15/236
Inventor 葛祥斌
Owner 福安药业集团烟台只楚药业有限公司
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