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A kind of vonemulin premix and its preparation method and application

A technology of Vonimulin and Vonimulin hydrochloride, applied in the directions of anti-inflammatory agents, pharmaceutical formulations, non-central analgesics, etc., can solve the problem that the comprehensive indicators cannot be satisfied, the defects cannot be effectively improved, and the defects cannot be effectively solved. and other problems, to achieve the ideal effect of dust reduction, the effect of dust reduction is remarkable, and the effect is suitable for promotion

Active Publication Date: 2020-05-15
山东中农普宁药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At this stage, various enterprises and scientific research institutes have conducted a lot of research on the products of Warney Mullin, but the research progress is slow, and the defects of Warney Mullin related products cannot be effectively improved. However, the disadvantages of vonemulin, such as bitter taste, strong hygroscopicity, strong irritation, relatively poor stability and difficult storage, have not been effectively solved, and the comprehensive indicators are still difficult to reach satisfactory standards. Therefore, it is urgent to develop Introduce a new Warney Millen product to improve existing defects

Method used

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  • A kind of vonemulin premix and its preparation method and application
  • A kind of vonemulin premix and its preparation method and application
  • A kind of vonemulin premix and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Applicable formulation screening of the new varnemulin premix:

[0066] Known by above-mentioned 4 test examples, what the present invention will solve is the micropowder molding of warnemulin in the warnemulin premix, the reduction of the dust in the production process (harm to the production personnel), the molding of the warnemulin particles and Increase efficiency and reduce side effects. The solution to these problems depends on the application of suitable excipients and combinations of excipients under appropriate processes.

[0067] (1) Preparation of new-type warnimulin premix products with different formulas

[0068] Material: The raw material formula is shown in Table 5, wherein the warnemulin is warnemulin hydrochloride.

[0069] Preparation process: prepare the new warnemulin premix according to the following method:

[0070] 1) Take the wheat bran and rice husk, stir-fry with a slow fire until they are browned according to the traditional Chinese medicin...

Embodiment 2

[0088] Investigation of the curative effect of new-type wonimulin premix on swine panting disease:

[0089] Product: with existing commercially available " warnemulin hydrochloride premix " as contrast; According to the product quality evaluation result of embodiment 1, choose the sample 59 prepared in embodiment 1 as the novel warnemulin premix for testing agent products.

[0090] Case: 90 panting pigs with natural onset in a pig farm in Leshan (short and continuous coughing of pigs, which are most likely to be heard when stimulated by cold air after leaving the pen in the morning, or before and after driving and feeding, and coughing at the same time A small amount of nasal clearing fluid, grayish white viscous or purulent nasal fluid when seriously ill).

[0091] Method: Under the same feeding conditions, the diseased pigs were randomly divided into positive control group, test group and negative control group; the positive control group was fed with 0.3% mixing material o...

Embodiment 3

[0098] Investigation on the prevention and control effect of new-type warnimulin premix against porcine Clostridioides welchii disease:

[0099] Product: with existing commercially available " warnemulin hydrochloride premix " as contrast, according to the product quality evaluation result of embodiment 1, choose the sample 59 prepared in embodiment 1 as test with warnemulin premix product.

[0100] Case: 66 pigs suffering from swine dysentery in a pig farm in Deyang (sick pigs pulled soft feces, yellow thin feces, mixed with mucus or blood; became thin, growth stagnated. Treponema hyodysenteriae was tested positive).

[0101] Method: Under the same feeding conditions, the pigs under test were randomly divided into a test group, a positive control group and a negative control group; the test group was fed with 0.3% mixing material with the new-type warnimulin premix prepared in Example 1; The positive control group was fed with commercially available 10% warnemulin hydrochlor...

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Abstract

The invention relates to the technical field of relevant antibiotic products, and particularly provides a novel valnemulin premix product as well as a preparation technology and application thereof. The novel valnemulin premix product comprises valnemulin hydrochloride and many other auxiliary materials such as an anti-caking agent, an adsorbent, an adhesive and a diluent according to a certain ratio. The preparation technology of the novel valnemulin premix product comprises the following steps: 1), preparing materials; 2), crushing and sieving; 3), uniformly mixing; 4), pulping; 5), drying and granulating. The novel valnemulin premix product and pig feed are mixed or feeding, the weight of the novel valnemulin premix product is 0.2% that of the pig feed, and a mixture is continuously fedfor 7 days. The novel valnemulin premix product provided by the invention not only has high drug availability, good animal compliance and a significant therapeutic effect on sick pigs, but also is prepared by the simple preparation technology, is convenient to produce and use and small in side effects, and especially has a relatively good therapeutic effect of preventing and treating cough asthma, swine dysentery and hyperpyrexia syndromes of the sick pigs.

Description

technical field [0001] The invention belongs to the related technical field of antibiotic products, and in particular relates to a veterinary antibiotic warnemulin premix, as well as the preparation process and application of the antibiotic. Background technique [0002] Valnemulin is a pleuromutilin semi-synthetic animal-specific antibiotic. It has strong antibacterial activity and a wide antibacterial spectrum. Mycoplasma, Mycoplasma gallisepticum, Mycoplasma pneumoniae), Streptococcus, Staphylococcus aureus, Actinobacillus, Pasteurella, Brachyspira hyodysenteriae and spirochete colonic pili-like all have good antibacterial activity, especially against Mycoplasma and Spirochetes are highly susceptible. Its antibacterial mechanism is similar to that of tiamulin, which inhibits protein synthesis by binding to the 50S subunit on the ribosome of pathogenic microorganisms. That is, by interacting with the ribosomes of pathogenic microorganisms, the synthesis of pathogenic mic...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K31/22A61K47/46A61K47/44A61K47/36A61P31/04A61P11/06A61P1/12A61P29/00
CPCA61K9/1641A61K9/1652A61K9/1664A61K31/22
Inventor 丁晓刚
Owner 山东中农普宁药业有限公司
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