Production method of ''W'' model of three-layer sharp composite membrane for improving fracture healing

Abstract

The invention provides a production method of a ''W'' model of a three-layer sharp composite membrane for improving fracture healing. The production method comprises the following steps: (1) producinga model in advance, wherein a vertex angle section of the model is inversed ''W''-shaped, and two protruded peaks are matched with a fracture line section; (2) respectively producing a wet elastic layer, a wet medicine layer and a wet guiding layer, wherein the elastic layer is a dense degradable or non-degradable biofilm, a medicine slow-release system with a bone healing promoting effect is encapsulated in the medicine layer, the medicine layer is produced from a material which is good in biocompatibility with human bones and is degradable or absorbent, and the guiding layer is produced from a porous loose material which is good in biocompatibility with human bones and is degradable or non-degradable and absorbent or non-absorbent; (3) covering the two protruded peaks of the model withthe wet elastic layer so as to cover the two protruded peaks, enabling the elastic layer to extend to two sides of the vertex angle of the model, covering the elastic layer with the wet medicine layer, and covering the medicine layer with the wet guiding layer; (4) after the three-layer composite film is air-dried and fixed in shape, stripping the three-layer composite film from the vertex angle of the model; and (5) cutting a ''W''-shaped membrane into a ''V''-shaped membrane.

Description

technical field [0001] The invention relates to a method for making a "W" model of a three-layer pointed composite membrane for improving fracture healing. Background technique [0002] At present, it is a frontier field of medical research to use a biocomposite film containing growth factors / stem cells to stick to the fracture line to enhance the speed and quality of fracture healing. There are blood vessels and bone cells distributed on the inner surface of the fracture line (anastomosis line), and whether the healing is good depends on the growth of blood vessels and bone cells in the fracture line. The reason why biofilm sticking to the surface of fracture anastomosis can increase the quality of fracture healing is that on the one hand, the drugs encapsulated in the biofilm can promote the growth of blood vessels and bone cells in the fracture anastomosis, and on the other hand, the biological The membrane isolates external muscles and other human tissues from the fract...

AI Technical Summary

Problems solved by technology

[0004] 1. The biocomposite membrane has a relatively large volume area and a small fracture area, and 2 cannot be effectively fitted and fixed together

[0005] 2. The limitations of the current biocomposite membrane materials and manufacturing process lead to performance indicators such as the degradation rate of the biocomposite membrane and the time for the carried growth factors to release the effective drug concentration (the duration of the effective concentration is the key to the healing quality of the fracture line) Unable to meet clinical needs

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