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Kit for screening lung cancer

A kit and reagent technology, applied in the field of lung cancer screening kits, can solve problems such as reports of no SOST expression, and achieve the effect of good clinical application prospects.

Active Publication Date: 2018-03-20
成都医学院第一附属医院
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

At present, there is no report on the expression of SOST in lung cancer

Method used

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  • Kit for screening lung cancer
  • Kit for screening lung cancer

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Experimental program
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Embodiment 1

[0024] Example 1 Detection of the expression level of SOST in lung cancer

[0025] 1. Experimental materials

[0026] Lung cancer tissue microarrays (HLugS060CD01 and HLug-Ade050CD-01) were purchased from Shanghai Xinchao Biotech. The microarray contains histopathological sections of lung cancer, including:

[0027] HLugS060CD01 tissue chip is a pathological chip of lung squamous cell carcinoma: 5 cases of normal lungs, 22 cases of adjacent / primary lung squamous cell carcinoma (clinical stage 1, 2, 3, 4), and 3 lung squamous cell carcinoma metastases Cases, 4 cases of negative / positive lymph nodes of lung squamous cell carcinoma.

[0028] HLug-Ade050CD-01 tissue chip is a pathological chip of lung adenocarcinoma: 5 cases of normal human lung, 14 cases of adjacent / primary lung adenocarcinoma (clinical stage 1, 2, 3, 4), lung gland There were 4 cases of cancer metastasis, 7 cases of negative lymph nodes and 6 cases of positive lymph nodes.

[0029] The anti-SOST polyclonal antibody was...

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Abstract

The invention discloses a kit for screening lung cancer. The kit comprises an optional kit for detecting the expression level of an SOST protein. The invention further discloses use of the kit for detecting the expression level of the SOST protein in the preparation of a kit for screening the lung cancer. By detecting the expression level of the SOST protein, the risk of a to-be-inspected person suffering from the lung cancer can be judged, and the kit can be applied to the clinical auxiliary diagnosis of the lung cancer, so that effective basis is provided for the utilization of relevant treatment measures or decisions by patients, and the kit has good clinical application prospects.

Description

Technical field [0001] The invention relates to a lung cancer screening kit. Background technique [0002] In the incidence and mortality of malignant tumors, lung cancer accounted for 13.0% and 19.4% respectively, ranking first among malignant tumors. In addition, affected by factors such as the intensification of China's population aging situation and the younger generation of smokers, the population base of lung cancer patients is still rising. Due to the heterogeneity of lung cancer, the effect of the same treatment on lung cancer is often different. Therefore, in the field of lung cancer clinical research and clinical treatment, an important part is to classify and stage lung cancer to minimize its heterogeneity. Improve treatment efficiency. [0003] At present, according to the differentiation degree and morphological characteristics of various types of lung cancer, lung cancer can be divided into small cell lung cancer, adenocarcinoma, squamous carcinoma and so on. Among...

Claims

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Application Information

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IPC IPC(8): G01N33/68G01N33/574
Inventor 许颖吴东明张涛杨菁
Owner 成都医学院第一附属医院
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