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Bone cement as well as preparation method and application thereof

A technology of bone cement and calcium phosphate bone cement, which is applied in the field of medical materials and can solve the problems of not being able to meet the clinical needs of vertebral body compression fractures

Active Publication Date: 2018-04-13
PEKING UNIV FIRST HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although this type of bone cement exists in the prior art, it is generally believed that they are only materials that can be used for bone defect repair, not materials for osteoporotic vertebral compression fractures, and cannot meet the requirements of glucocorticoid-induced osteoporosis (GIOP). Clinical needs for vertebral compression fractures resulting in

Method used

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  • Bone cement as well as preparation method and application thereof
  • Bone cement as well as preparation method and application thereof
  • Bone cement as well as preparation method and application thereof

Examples

Experimental program
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preparation example Construction

[0046] Preparation of Nano Silver-Diatomite (nAgDT)

[0047] The inventors analyzed the toxicity of diatomite in different shapes and sizes after calcining, separating and purifying the diatomite particles. Through the biocompatibility and toxicity analysis of diatomite, it is found that the disc-shaped diatomite (DT30-disk) with a particle size of about 30 μm has better biocompatibility. Add diatomite particles (DT30-disk) to the silver ammonia solution and stir, then add glucose, and after the reduction reaction, silver is deposited on the surface of the diatomite particles to form silver-diatomite (nAgDT).

[0048] Preparation of bone cement of the present application

[0049] The formula of calcium phosphate cement (CPC) is α-TCP:DCPD=90-95:5-10. After mixing α-TCP and DCPD in proportion, put it into a ball mill jar, add an appropriate amount of absolute ethanol, mill it (for example, at a speed of about 464rpm for about 10 hours), put it in an oven at about 60°C for...

Embodiment 1

[0087] Example 1: Research on the Physical Properties of Antibacterial Bone Cement

[0088] Provide CPC, CPC-starch, CPC-starch / nAgDT (1wt%), CPC-starch / nAgDT (5wt%) and CPC-starch / nAgDT (10wt%) prepared in the above-mentioned materials and methods, and according to the above-mentioned method respectively The injectability, setting time and compressive strength of various bone cement systems were determined. Table 1 shows the measurement results.

[0089] Table 1: Injection performance, setting time and compressive strength of various bone cement systems

[0090]

[0091] We found that compared with CPC and CPC-starch, CPC-starch / nAgDT (1wt%), CPC-starch / nAgDT (5wt%) and CPC-starch / nAgDT (10wt%) had better performance in injectability, initial setting time t i (min), final setting time t f (min) and compressive strength (MPa) have achieved comparable or better results, where surprisingly, we found that the injection properties of CPC-starch / nAgDT, initial setting time,...

Embodiment 2

[0092] Embodiment 2: antibacterial research of antibacterial bone cement

[0093] In the antibacterial experiment, two kinds of bacteria, Staphylococcus aureus (Gram-negative bacteria) and Escherichia coli (Gram-positive bacteria), were selected for testing.

[0094] The silver diatomite composite calcium phosphate bone cement containing 1w.t.% was mixed with PBS solution to form gradient solutions with different nAgDT contents, which were 1, 0.5 and 0.1 mg / mL respectively, to detect the silver-loaded diatomite composite bone cement. Antimicrobial properties of cement. Inoculate 1 inoculation loop of bacteria Staphylococcus aureus and Escherichia coli into 10ml LB liquid medium and culture at 220rpm at 37°C. After 12 hours of culture, collect all samples and suspend all bacteria in LB medium by ultrasonic , to count the number of colonies. Then mix 50 mL LB liquid medium with 100 μL density of 10 5 The cfu / ml bacterial suspension was mixed, and after mixing evenly, 1 ml of ...

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Abstract

The invention relates to bone cement as well as a preparation method and application thereof. The bone cement is prepared from 50 to 92 weight percent of alpha-tricalcium phosphate, 3 to 10 weight percent of dicalcium phosphate dihydrate, 2 to 30 weight percent of starch and 0.5 to 15 weight percent of nano-silver loaded diatomite. The bone cement disclosed by the invention has the advantages of injection, antibacterial property and degradability, and can be used for treating vertebral compression fracture caused by osteoporosis induced by glucocorticoid.

Description

technical field [0001] The present invention relates generally to the field of medical materials, and more particularly to bone cements, their preparation methods and uses. Background technique [0002] Percutaneous vertebroplasty is a common method for the treatment of osteoporotic vertebral compression fractures. The medical bone cement used is generally non-degradable polymethyl methacrylate (PMMA) material. PMMA is a biologically inert material that cannot form an organic chemical interface with the host bone tissue. In addition, the heat generated during the solidification polymerization process, the cytotoxicity of the monomer, and the limited operability time also limit its clinical application. [0003] There are other types of bone cements in the prior art, such as calcium phosphate bone cement and calcium sulfate bone cement. For example, Chinese patent application CN 104857568A discloses antibacterial calcium sulfate-based bone cement and its preparation method,...

Claims

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Application Information

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IPC IPC(8): A61L27/20A61L27/12A61L27/02A61L27/50A61L27/54A61L27/58
CPCA61L27/025A61L27/12A61L27/20A61L27/50A61L27/54A61L27/58A61L2300/104A61L2300/404A61L2400/06C08L3/02
Inventor 孙浩林刘慧玲李绪文胡博张祥李淳德杨磊
Owner PEKING UNIV FIRST HOSPITAL
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