Preparation method of composite bone reconstruction scaffold with bone tumor resistance

A technology of bone tumor and compound is applied in the field of preparation of anti-bone tumor composite bone reconstruction scaffold, which can solve problems such as slow recovery, and achieve the effects of preventing secondary injury, good fusion, and promoting bone growth and recovery.

Inactive Publication Date: 2018-01-09
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional treatment for osteoma is to use large resection to remove the normal tissue around the tumor. For the residual bone defect, it can be repaired by autogenous bone inactivation and replantation, large bone

Method used

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preparation example Construction

[0015] A method for preparing an anti-bone tumor composite bone reconstruction scaffold, comprising the following raw materials and weight fractions: 20-30 parts by mass of polyamide; 20-25 parts by mass of strontium compound; 15-20 parts by mass of hydroxyapatite; calcium phosphate 50 to 60 parts by mass; 5 to 10 parts by mass for alkaline phosphatase; 50 to 60 parts by mass for α-tricalcium phosphate; 50 to 60 parts by mass for calcium hydrogen phosphate; 20 to 30 parts by mass for disodium hydrogen phosphate Calcium sulfate powder is 20 to 30 parts by mass; hydrochloride is 5 to 10 parts by mass; calcium bicarbonate suspension is 10 to 20 parts by mass; phosphoric acid is 10 to 20 parts by mass and collagen solution is 10 to 20 parts by mass .

[0016] The anti-bone tumor composite bone reconstruction scaffold includes the following raw materials and weight fractions: 20 parts by mass of polyamide; 20 parts by mass of strontium compound; 15 parts by mass of hydroxyapatite; ...

Embodiment 1

[0026] A method for preparing an anti-bone tumor composite bone reconstruction scaffold, comprising the following raw materials and weight fractions: 20-30 parts by mass of polyamide; 20-25 parts by mass of strontium compound; 15-20 parts by mass of hydroxyapatite; calcium phosphate 50 to 60 parts by mass; 5 to 10 parts by mass for alkaline phosphatase; 50 to 60 parts by mass for α-tricalcium phosphate; 50 to 60 parts by mass for calcium hydrogen phosphate; 20 to 30 parts by mass for disodium hydrogen phosphate Calcium sulfate powder is 20 to 30 parts by mass; hydrochloride is 5 to 10 parts by mass; calcium bicarbonate suspension is 10 to 20 parts by mass; phosphoric acid is 10 to 20 parts by mass and collagen solution is 10 to 20 parts by mass .

[0027] The manufacturing process steps are as follows:

[0028] a. Weighing the above-mentioned raw materials according to parts by weight to prepare a composite bone reconstruction scaffold;

[0029] b. Calcium phosphate, tricalc...

Embodiment 2

[0035] A method for preparing an anti-bone tumor composite bone reconstruction scaffold, comprising the following raw materials and weight fractions: 20 parts by mass of polyamide; 20 parts by mass of strontium compound; 15 parts by mass of hydroxyapatite; 50 parts by mass of calcium phosphate; 5 parts by mass of active phosphatase; 50 parts by mass of α-tricalcium phosphate; 50 parts by mass of calcium hydrogen phosphate; 20 parts by mass of disodium hydrogen phosphate; 20 parts by mass of calcium sulfate powder; 5 parts by mass of hydrochloride ; Calcium bicarbonate suspension is 10 parts by mass; phosphoric acid is 10 parts by mass and collagen solution is 10 parts by mass.

[0036] The manufacturing process steps are as follows:

[0037] a. Weighing the above-mentioned raw materials according to parts by weight to prepare a composite bone reconstruction scaffold;

[0038] b. Calcium phosphate, tricalcium phosphate, calcium hydrogen phosphate and calcium sulfate powder are...

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PUM

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Abstract

The invention discloses a preparation method of a composite bone reconstruction scaffold with bone tumor resistance. The preparation method is prepared from raw materials in parts by mass as follows:20-30 parts of polyamide, 20-25 parts of a strontium compound, 15-20 parts of hydroxyapatite, 50-60 parts of calcium phosphate, 5-10 parts of alkaline phosphatase, 50-60 parts of alpha-tricalcium phosphate, 50-60 parts of calcium hydrogen phosphate, 20-30 parts of disodium hydrogen phosphate, 20-30 parts of calcium sulfate powder, 5-10 parts of hydrochloride, 10-20 parts of a calcium hydrogen carbonate suspension, 10-20 parts of phosphoric acid and 10-20 parts of a collagen solution. The composite bone reconstruction scaffold has good integration and can fix injured bone after being contactedwith human bone to prevent secondary injury on one hand and supplement calcium ions to the injured bone to promote growth and recovery of the bone on the other hand.

Description

technical field [0001] The invention relates to the technical field of composite bone reconstruction scaffolds, in particular to a preparation method of an anti-bone tumor composite bone reconstruction scaffold. Background technique [0002] Bone tumor treatment is a comprehensive treatment that combines surgery, chemotherapy and radiotherapy. Due to the limb-salvage treatment of malignant bone tumors in the limbs, the adjacent structures of malignant bone tumors in the spine are complicated, and it is difficult to completely remove the lesion. Preventing recurrence after surgery has become more and more important. However, this problem and the lack of a large amount of bone graft materials required for bone reconstruction after tumor resection are still difficult problems for surgeons. They are the bottleneck affecting the treatment effect of bone tumors and the development of treatment concepts. The traditional treatment for osteoma is to use large resection to remove the ...

Claims

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Application Information

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IPC IPC(8): A61L27/24A61L27/02A61L27/12A61L27/18A61L27/54
Inventor 张善勇郭杰吴敏飞郑长军杨小玉王金成赵健武白云深刘钦毅曲扬郑健航陈炳鹏张汉阳
Owner JILIN UNIV
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