Two-phase alpha-tricalcium phosphate/oxyhydrogen-base apatite bone cement and its preparing process

A technology of hydroxyapatite and calcium phosphate, applied in medical science, prosthesis, coating, etc., can solve the problems of limited efficacy and inability to contact with bone tissue.

Inactive Publication Date: 2005-10-05
PURZER PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because the calcium-phosphorus powder mixed into the material is often completely covered by the polymer material and cannot contact the bone tissue, its improved efficacy is still limited.

Method used

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  • Two-phase alpha-tricalcium phosphate/oxyhydrogen-base apatite bone cement and its preparing process
  • Two-phase alpha-tricalcium phosphate/oxyhydrogen-base apatite bone cement and its preparing process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Weigh 0.219 grams of ammonium phosphate (AP) powder and dissolve it in deionized water, then pour a fixed amount of 20 grams of hydroxide apatite (HAP) powder into the AP solution and mix it uniformly, and then in a 70°C Dry in the oven for three days. The dried powder mixture of AP and HAP was placed in a platinum crucible, and the temperature was raised to 1350°C at a heating rate of 10°C / min in a programmable SiC high-temperature furnace, and the temperature was kept at 1350°C for one hour, and then cooled rapidly , which is rapidly cooled from 1350°C to room temperature, so that a two-phase crystal composition with a weight composition ratio of α-tricalcium phosphate / hydroxyapatite of 10 / 90 (hereinafter referred to as A10H90) can be obtained.

Embodiment 2 to 9

[0027] Repeat the steps of Example 1, but take different weights of ammonium phosphate (AP) powders to obtain α-tricalcium phosphate / hydroxyapatite weight composition ratios of 20 / 80, 30 / 70, 40 / 60 , 50 / 50, 60 / 40, 70 / 30, 80 / 20, 90 / 10 products (respectively referred to as A20H80, A30H70, A40H60, A50H50, A60H40, A70H30, A80H20, A90H10), as shown in Table 1.

[0028] Table I:

[0029] Example

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Abstract

A two-phase alpha-TCP / HAP bone cement contains alpha-tricalcium phasphate (30-60 wt.%) and hydroxide apatite (40-70 wt.%) and features that it can be quickly settled when it is immersed in aqueous solution, so it is an excellent bone cement. Its preparing process is also disclosed, which features that the ratio of both components in it can be controlled.

Description

technical field [0001] The present invention relates to bone cement materials, in particular to α-tricalcium phosphate / hydroxyapatite two-phase bone cement which can be used as bone filling material. The invention also relates to the manufacturing method of α-tricalcium phosphate / hydroxyapatite two-phase bone cement. Background technique [0002] When the bones of the human body are traumatized, bone tumors or tumors grow and part of the bone is excavated to form a bone block, appropriate bone filling materials or bone cement are often needed to repair and fill the bone defect. [0003] The known bone cement is mainly made of polymer materials, such as acrylic resin and high-density polyethylene. Due to the poor bio-affinity of polymer materials, some researchers try to add some calcium-phosphorus salts with better bio-affinity and direct bonding with bone tissue, such as hydroxyapatite ( hydroxyapatite, Ca 10 (PO 4 ) 6 (OH) 2 , HAP) or tricalcium phosphate (Ca 3 (PO ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/00A61L27/32
Inventor 林峰辉廖俊仁
Owner PURZER PHARMA
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