Preparation method capable of monitoring degraded bone cement with NIRII region fluorescent light, degraded bone cement product and application of degraded bone cement product

A technology of bone cement and fluorescence, which is applied in pharmaceutical formulations, pharmaceutical sciences, prostheses, etc., can solve problems such as easy transfer to bone tissue, and achieve the effects of improved injectability, simple raw materials, and simple preparation methods.

Inactive Publication Date: 2019-04-12
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The incidence of primary bone tumors is low, but due to the special environment of bone, solid tumors are eas

Method used

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  • Preparation method capable of monitoring degraded bone cement with NIRII region fluorescent light, degraded bone cement product and application of degraded bone cement product
  • Preparation method capable of monitoring degraded bone cement with NIRII region fluorescent light, degraded bone cement product and application of degraded bone cement product
  • Preparation method capable of monitoring degraded bone cement with NIRII region fluorescent light, degraded bone cement product and application of degraded bone cement product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A kind of degradable bone cement that can be monitored by fluorescence in the NIRII area, with alpha-tricalcium phosphate, hydroxyapatite, and calcium sulfate hemihydrate as the solid part of the main bone repair components, adding hydroxypropyl methylcellulose, phosphorylated shell Glycans, gelatin biocompatible macromolecular components; the other part is modified Ag 2 S quantum dots, and the solution part is sodium hydrogen phosphate solution, prepared according to the following steps:

[0028] PEI-coated Ag 2 Preparation of S quantum dots: In a 200ml flask, add 0.2mmol Ag +ion and 0.8mmol PEI, and configure 20ml ultrapure water, stir the mixed solution under nitrogen and room temperature for 30 minutes to form PEI-Ag (+1 valence) complex, then, add 2ml 0.025mmol S-N 2 h 4 h 2 O aqueous solution was added to the above solution to obtain a brown solution, which was kept stirring for 30 minutes. After the reduction was completed, isopropanol was added to precipita...

Embodiment 2

[0034] A NIRII zone fluorescence monitorable degradable bone cement, Ag wrapped in PEI 2 The preparation of S quantum dots is the same as in Example 1, and is prepared according to the following steps:

[0035] Disperse alpha-tricalcium phosphate and calcium sulfate hemihydrate into a 40g / L solution in absolute ethanol, mix at 400rpm and carry out liquid phase grinding for 4h, then add 0.5% gelatin, continue ball milling in a ball mill for 15min, and the resulting solution Bone cement powder was obtained after rotary evaporation.

[0036] Weigh 0.1g of phosphorylated chitosan, 0.15g of gelatin, and 0.1g of hydroxypropyl methylcellulose, dissolve them in 19.65g of sodium hydrogen phosphate solution, and then add 40mg of PEI-wrapped Ag in the solution. 2 S quantum dots were uniformly mixed by ultrasound to prepare 20% sodium hydrogen phosphate, 1% phosphorylated chitosan, 1.5% gelatin, 1% hydroxypropyl methylcellulose and 0.04% PEI-coated Ag 2 Bone cement solidification soluti...

Embodiment 3

[0039] A NIRII zone fluorescence monitorable degradable bone cement, Ag wrapped in PEI 2 The preparation of S quantum dots is the same as in Example 1, and is prepared according to the following steps:

[0040] Disperse alpha-tricalcium phosphate and calcium sulfate hemihydrate into a 40g / L solution in absolute ethanol, mix at 400rpm and carry out liquid phase grinding for 4h, then add 0.5% gelatin, continue ball milling in a ball mill for 15min, and the resulting solution Bone cement powder was obtained after rotary evaporation.

[0041] Weigh 0.1g of phosphorylated chitosan, 0.15g of gelatin, and 0.1g of hydroxypropyl methylcellulose, dissolve them in 19.65g of sodium hydrogen phosphate solution, and then add 100mg of PEI-wrapped Ag in the solution. 2 S quantum dots were uniformly mixed by ultrasound to prepare 20% sodium hydrogen phosphate, 1% phosphorylated chitosan, 1.5% gelatin, 1% hydroxypropyl methylcellulose and 0.1% PEI-coated Ag 2 Bone cement solidification soluti...

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Abstract

The invention relates to a preparation method capable of monitoring degraded bone cement with NIRII region fluorescent light, a degraded bone cement product and an application of the degraded bone cement product. For solid parts, alpha-tricalcium phosphate of which the particle diameter is 15-100nm and calcium sulphate of which the particle diameter is 20-100um are used as main sclerotin repair components, biocompatibility macromolecule components of hyaluronic acid, phosphorylation chitosan, gelatin and the like are added so as to improve the fluidity of inorganic granules, and the biocompatibility macromolecule components are used as repair function parts capable of injecting bone cement; and the other part is Ag2S quantum dots of which the components are modified so as to give a near-infrared developed function for a repair material system. The solution part is a monosodium phosphate solution so as to promote cross-linking of alpha-calcium phosphate granules and near-infrared calcium sulphate granules so as to construct a bearing structure. An appropriate quantity of Ag2S quantum dot components are added to the bone cement, the bone cement can develop so as to monitor the degradation rate under NIRII region fluorescent light, and the preparation method can be used for tracking internalization absorption of bone materials.

Description

technical field [0001] The invention relates to a method in the technical field of biomedical materials, and relates to a preparation method of a degradable bone cement that can be monitored by fluorescence in the NIRII region, as well as its product and application. technical background [0002] Fluorescent probes in the near-infrared region II (NIR-II) are nanomaterials with emission wavelengths in the range of 900-1400nm after excitation, which are comparable to fluorescent probes in the visible light (450-750nm) and near-infrared region I (750-900nm) Compared with that, nanoprobes located in NIR-II have great advantages in their optical properties. One is that in NIR-II, the absorption and scattering of light by tissues is far less than that in the visible region and NIR-I, and it helps to improve the spatial resolution of NIR-II fluorescent probes. Second, in this wavelength range, tissues The autofluorescence is extremely weak, which greatly improves the signal-to-noi...

Claims

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Application Information

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IPC IPC(8): A61L27/02A61L27/12A61L27/20A61L27/22A61L27/50A61L27/58
CPCA61L27/025A61L27/12A61L27/20A61L27/222A61L27/50A61L27/58A61L2400/06A61L2430/02C08L1/284C08L5/08
Inventor 何丹农严一楠刘训伟杨迪诚王杰林王萍金彩虹
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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