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Biological porous bone cement prepared by compositing Sr-doped calcium-phosphorus bioglass and alpha-tricalcium phosphate and preparation method thereof

A technology of bioglass and tricalcium phosphate, which is applied in the field of biomedical material preparation, can solve the problems of low compressive strength of bone cement, difficulty in forming porous structure, unfavorable vascular ingrowth and body fluid circulation, etc., so as to facilitate body fluid circulation and dissolve quickly The effect of speed and good application prospects

Inactive Publication Date: 2012-11-21
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The degradation performance of bone cement has not been fundamentally improved, so it is difficult to form an ideal porous structure, which is not conducive to blood vessel ingrowth and body fluid circulation
Although the use of pore-forming agents or organic templates can obtain bone cement scaffolds with high porosity and form a porous structure, the compressive strength of bone cement is low, which cannot meet the requirements of bone tissue repair for bone cement strength

Method used

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  • Biological porous bone cement prepared by compositing Sr-doped calcium-phosphorus bioglass and alpha-tricalcium phosphate and preparation method thereof
  • Biological porous bone cement prepared by compositing Sr-doped calcium-phosphorus bioglass and alpha-tricalcium phosphate and preparation method thereof
  • Biological porous bone cement prepared by compositing Sr-doped calcium-phosphorus bioglass and alpha-tricalcium phosphate and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Step 1: Preparation of Sr-doped calcium phosphorus bioglass

[0023] Calcium nitrate tetrahydrate, phosphorus pentoxide, strontium nitrate, and sodium nitrate are used as raw materials, and the corresponding substances are weighed in molar ratios, so that the oxides corresponding to each substance in the raw materials are calculated according to CaO:P 2 o 5 :SrO:Na 2 The molar percentage of O is 50:40:3:7 to prepare calcium phosphorus bioglass. 8.517g P 2 o 5 Dissolve in 40ml of absolute ethanol, control the temperature not to exceed 38.0°C during the addition process, stir until the solution becomes a clear and transparent phosphorus-based precursor solution, and let the solution stand for 24 hours before use. Weigh 0.952gSr(NO 3 ) 2 , 17.711g Ca(NO 3 ) 2 4H 2 O, 1.785g NaNO 3 , dissolved in 45ml of distilled water in this order to form a transparent and clear solution. The obtained solution was added dropwise to the phosphorus-based precursor solution to ob...

Embodiment 2

[0029] Step 1: Preparation of Sr-doped calcium phosphorus bioglass

[0030] Except that the molar percentages of calcium nitrate tetrahydrate and strontium nitrate in the bioglass are different, other operations are the same as step 1 in Example 1. Calcium nitrate tetrahydrate, phosphorus pentoxide, strontium nitrate, and sodium nitrate are used as raw materials, and the corresponding substances are weighed in molar ratios, so that the oxides corresponding to each substance in the raw materials are calculated according to CaO:P 2 o 5 :SrO:Na 2 The molar percentage of O is 44:40:9:7 to prepare calcium phosphorus bioglass. 8.517g P 2 o 5 Dissolve in 40ml of absolute ethanol, control the temperature not to exceed 38.0°C during the addition process, stir until the solution becomes a clear and transparent phosphorus-based precursor solution, and let the solution stand for 24 hours before use. Weigh 2.857gSr(NO 3 ) 2 , 15.586g Ca(NO 3 ) 2 4H 2 O, 1.785g NaNO 3 , dissolved...

Embodiment 3

[0034] Step 1: Preparation of Sr-doped calcium phosphorus bioglass

[0035] Except that the molar percentages of calcium nitrate tetrahydrate and strontium nitrate in the bioglass are different, other operations are the same as step 1 in Example 1. Calcium nitrate tetrahydrate, phosphorus pentoxide, strontium nitrate, and sodium nitrate are used as raw materials, and the corresponding substances are weighed in molar ratios, so that the oxides corresponding to each substance in the raw materials are calculated according to CaO:P 2 o 5 :SrO:Na 2 The molar percentage of O is 42:40:11:7 to prepare calcium phosphorus bioglass. 8.517gP 2 o 5 Dissolve in 40ml of absolute ethanol, control the temperature not to exceed 38.0°C during the addition process, stir until the solution becomes a clear and transparent phosphorus-based precursor solution, and let the solution stand for 24 hours before use. Weigh 3.492g Sr(NO 3 ) 2 , 15.586g Ca(NO 3 ) 2 4H 2 O, 1.785g NaNO 3 , dissolve...

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Abstract

The invention relates to a biological porous bone cement prepared by compositing Sr-doped calcium-phosphorus bioglass and alpha-tricalcium phosphate and a preparation method thereof. The bone cement provided by the invention is characterized in that the porousness of the bone cement is 39-57%, and the size of a micropore is between 0.5 um and 4 um; and the compression strength is 23.6-38.5 Mpa. In the invention, through compositing the Sr-doped calcium-phosphorus bioglass and alpha-tricalcium phosphate, the porous-structured bone cement is formed. In the invention, the solidification time andmicrostructure of the bone cement can be adjusted through the rapid dissolving of the Sr-doped calcium-phosphorus glass so as to form a porous structure with a high porousness, and the degradation property of a hydrated product (hydroxyapatite) can be improved; and in addition, by virtue of Sr ions introduced by biodegradable calcium-phosphorus glass, the compression strength of the bone cement is improved, thereby achieving the properties such as high strength and good degradability of the bone cement better.

Description

technical field [0001] The invention relates to a Sr-doped calcium phosphorus bioglass composite α-tricalcium phosphate bioporous bone cement and a preparation method, and belongs to the technical field of biomedical material preparation. Background technique [0002] Calcium Phosphate Cement (CPC) is a new type of artificial bone material that can be used for bone tissue repair. Due to its excellent biocompatibility and in-situ curing in the form of slurry, it can be directly injected into the bone defect site for in situ curing, which solves the problem of difficult shape adaptability of other inorganic biomaterials, so it is widely used in orthopedics, dentistry and plastic surgery. widely used. At the same time, CPC can also be used as an excellent slow-release carrier for antibiotics, anti-tumor drugs and various growth factors. Among them, curing time and product structure are two important factors to measure whether bone cement can meet clinical requirements. In or...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C04B38/00C04B28/34
CPCC04B14/22C04B35/447C04B28/344C04B38/0054
Inventor 蔡舒汪乾翟羽佳窦瑛
Owner TIANJIN UNIV
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