Defoamer composition for medicine production and preparation method thereof

Abstract

The invention provides a defoamer composition for pharmaceutical production, which is prepared from the following components in parts by mass: 20-60 parts of dimethyl silicone oil, 20-30 parts of polymethylsiloxane, fluorosilicone oil 2‑10 parts, 4‑8 parts of thickener, 10‑15 parts of emulsifier, 10‑100 parts of deionized water. The defoamer composition can efficiently eliminate and suppress foaming, has stable performance, less dosage, is non-toxic and environment-friendly.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a defoamer composition for medicine production and a preparation method thereof. Background technique [0002] Liquid foam is a common and serious problem in industrial production. During the paper pulping process, the slurry will generate a lot of surface active substances in situ, and at the same time, the high mechanical force will cause a large amount of air to be mixed in, so air bubbles are easily generated. When the foaming phenomenon is serious, it will greatly reduce the efficiency of pulp washing, and bring great difficulties to conveying and bleaching, affect the quality of pulp, seriously affect production efficiency, and increase the risk of environmental pollution. [0003] At present, defoamers commonly used in industry are usually divided into three categories: polyether defoamers, organic defoamers and silicone defoamers. Compared with the other tw...

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Problems solved by technology

[0004] At present, in the production of antibiotics and vitamin medicines by microorganisms, foams are often encountered, especially in the fermentation process of using air to stir materials, there will be a lot of foams, and the generation and accumulation of foams make the fermentation process impossible. In normal operation, there will often be an overflow of fermentation broth (due to the growth of organisms that need to inhale a large amount of oxygen and discharge a large amount of carbon dioxide

This forms a foam layer containing a large amount of gas, which will grow and accumulate with the growth of the organism, resulting in overflow), which in turn leads to a lack of oxygen supply in the tank, low yield, and insufficient utilization of the fermentation body and To solve the defoaming problem, soybean oil is mostly used to defoam at present, but this method will cause obstacles to the subsequent processes such as bacterial cell separation, concentration, and product separation, and the cost is high, and the defoaming effect is not ideal

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