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Extracts of microalgae and their application

An extract, microalgae technology, applied in hair care and skin care applications, the field of microalgae extracts, can solve problems such as no fat metabolism regulation

Inactive Publication Date: 2018-04-17
SYMRISE GMBH & CO KG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Japanese patent JP 2000072642A1 (Lion) proposes weight loss preparations obtained from some species of macroalgae, however, there is no prior art available regarding fat metabolism regulation based on preparations obtained from the microalgae strains considered here
[0015] The state of the art is completely silent on the issues of regulation of the stratum corneum of the skin and lipolysis

Method used

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  • Extracts of microalgae and their application
  • Extracts of microalgae and their application
  • Extracts of microalgae and their application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 to 2

[0460] The activity of direct methanol (d-MeOH) extracted from Chaetoceros on hair follicle growth

[0461] The hair follicles were taken from a scalp sample of a single donor and transferred to a sterile 24-well plate for cultivation by using a modified Williams' Medium E medium. The culture was carried out for ten days, and the experimental treatment of hair follicles was carried out for 24 hours from the beginning of the culture. After 18 hours of culture, the hair follicles were selected for the experiment. Only those hair follicles that exhibit a good state of life and grow at least 0.2 mm are considered suitable for cultivation. All the prepared experimental groups and control groups included 12 hair follicles, which were inoculated into a 24-well plate at a density of 3 hair follicles / well. The hair follicles that showed obvious signs of tolerance due to non-experimental treatment during the culture process were excluded from the final analysis. In the case of a direct ...

Embodiment 3 to 4

[0467] Activity of direct ethanol (d-EtOH) extract obtained from Chaetoceros calcareous dwarf variant on hair follicle growth

[0468] The previously described experimental protocol was used to study the activity of direct ethanol extracts obtained from Chaetoceros calciformis on hair follicle growth. The experiment was repeated twice using hair follicles taken from two donors. The reported results are calculated by collecting recorded data and are shown in Table 3.

[0469] table 3

[0470] The growth-elongation of the hair follicle is expressed as a% ratio of the performance of the control group. Data pooled from two of the two test donors (response = 100%)

[0471] Example

[0472] Direct ethanol extract stimulates hair follicle growth and induces an increase in elongation, varying from 17% to 20%. These two results are statistically significant, however, the best response was detected by treating the hair follicles with 1 μg / ml extract.

Embodiment 5 to 6

[0474] The activity of direct isopropyl (d-iPrOH) alcohol extract obtained from Chaetoceros on hair follicle growth

[0475] The previously described experimental protocol was used to study the activity of direct isopropyl alcohol extracts obtained from Chaetoceros on the growth of hair follicles. In Table 4, the results of a single experiment are reported.

[0476] Table 4

[0477] The growth-elongation of the hair follicle is expressed as a% ratio of the performance of the control group. (Data from a single experiment)

[0478] Example

[0479] Direct isopropanol extract inhibits hair follicle growth, resulting in a decrease in elongation, varying from -24% to -31%. The best response was detected by treating hair follicles with 10 μg / ml extract, and the result was very statistically significant.

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Abstract

The invention relates to a cosmetic composition which includes extracts of Monodus sp., Chaetoceros sp. and / or Chlorococcum sp. and cosmetically acceptable auxiliary materials selecting from the groupconsisting of C1-C4 aliphatic alcohols, polyhydric alcohols having 3 to 12 carbon atoms, oil compositions, water and their mixtures, wherein the extracts are obtained by treating said microalgae witha solvent selected from the group consisting of C1-C4 aliphatic alcohols, ethyl acetate, water or their mixtures, removing the dissolved extracts from the residues and recovering the pure extracts from the solvent. The extracts show excellent properties particularly in modulating the metabolism of human skin and hair follicles. The invention also relates to the purpose of the cosmetic composition, and non-therapeutic methods for treating human skin and / or hair by using the cosmetic composition.

Description

[0001] This application is a subdivision of the invention patent application whose application date is October 13, 2011, the Chinese patent application number is 201180061149.5 (the international application number is PCT / EP2011 / 067945), and the invention title is "microalgae extracts and applications". Case application. Technical field [0002] The present invention relates to the field of cosmetics and toiletries, and relates to extracts of microalgae, methods and compositions for obtaining the extracts, and their use in hair care and skin care applications. Background technique [0003] The cosmetics and toiletries industry has invested a lot of interest in identifying natural compounds suitable for the preparation of body care products, especially anti-aging products. The decline in the birth rate and the extension of life span experienced by industrialized economies has increased the impact of anti-aging products in the health care and cosmetics market. [0004] Wrinkles repre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9706A61Q5/00A61Q7/00A61Q7/02A61Q19/00A61Q19/02A61Q19/04A61Q19/08
CPCA61K8/97A61Q5/00A61Q7/00A61Q7/02A61Q19/00A61Q19/02A61Q19/04A61Q19/08A61Q19/06A61K8/34A61K8/37A61P17/02A61K8/9722A61K8/9794A61K36/02A61K8/9706
Inventor 洛伦佐·扎内拉保罗·佩尔蒂莱米歇尔·马西罗尼马科·马西罗尼埃里萨·卡维奥拉
Owner SYMRISE GMBH & CO KG
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