The invention relates to a preparation and feeding method of sustained-release pellet feed for the artificial breeding of corals. The method is characterized by comprising the following steps: (1) weighing mysid, mussel gonad, ulva and kelp, adding an appropriate amount of seawater, wet grinding into thick pulp, adding raw materials such as calcium oxide, fish oil, nannochloris oculata powder, yeast powder, rhodospira rubrum powder, vitamins, MgSO4, carboxymethylcellulose, and yam powder, adding an appropriate amount of seawater, uniformly mixing to obtain a wet-clustered mixture, extruding and granulating the wet-clustered mixture by using a granulating machine, air drying or drying with hot air to obtain the sustained-release pellet feed for the artificial breeding of the corals; and (2) loading the sustained-release pellet feed in a mesh bag, immersing the mesh bag containing the pellet feed in water, and fixing at a position of 150 to 200 mm above the coral spikelet. The sustained release rate of the sustained-release feed is regulated to be roughly the same with a predation rate of the coral, so that the utilization rate of the feed is increased, the cost of the feed is reduced, and the eutrophication of the water quality in the coral cultivating water tank environment is reduced.