A kind of levocetirizine injection

Abstract

The invention discloses a new dosage form of levocetirizine injection and a method for preparing levocetirizine injection. A levocetirizine, pH regulator, osmotic pressure regulator and other raw materials are used to prepare a levocetirizine injection. A cetirizine hydrochloride injection with stable content, low impurity content, and long validity period. The levocetirizine injection prepared by the present invention is safe and effective, can effectively relieve and eliminate allergic reactions, and has no unwanted hemolytic reactions, filling This kind of technology gap at home and abroad has been filled.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, in particular to a levocetirizine injection. Background technique [0002] The World Health Organization has listed allergic diseases as one of the three major diseases that need to be studied and prevented in the 21st century. The incidence rate of allergic diseases in my country is nearly 40%, and the incidence rate in coastal cities is higher than that in inland areas, and that in heavy industrial cities is higher than that in light industrial cities. According to statistics, the current retail market capacity of anti-allergic drugs in my country is about 1.2 billion yuan, and the market potential is huge. Antihistamines are widely used clinically, mainly for the desensitization treatment of allergic diseases of the human immune system, and play an important role in the treatment of urticaria, allergic dermatitis, allergic rhinitis and allergic asthma. [0003] After year...

AI Technical Summary

Problems solved by technology

Conventional wisdom holds that non-sedating antihistamines cannot be administered by the traditional parenteral route due to their insolubility, but among second- and third-generation antihistamines, only cetirizine-based compounds have been found to be in water Soluble, i.e. only compounds derived from cetirizine or its isomers are soluble in water and can be successfully formulated as parenteral injectable products, especially for cetirizine and its isomer levocetirizine Intravenous injection has almost no hemolytic effect of its parent hydroxyzine

[0006] However, the current levocetirizine has the disadvantage of unstable properties, and it is very easy to chemically react with other substances in the formula, thereby affecting the quality of the product and possibly affecting the safety of the product

In addition, after levocetirizine is prepared as an injection, the content is unstable, the impurity content is high, and the validity period is short, which is not conducive to the transportation and storage of the product, and there are potential safety problems

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