12 results about "Levocetrizine" patented technology

The present invention relates to solid compositions. The present invention addresses the problem of providing a solid composition containing at least one substance selected from the group consisting of tepiperidine and salts thereof, and at least one substance selected from the group consisting of tranexamic acid and salts thereof, in which the dissolution of tepiperidine is improved. [Solution] A solid composition containing the following components: (A) at least one substance selected from the group consisting of tepiperidine and salts thereof; (B) at least one substance selected from the group consisting of tranexamic acid and salts thereof; and (C) at least one compound selected from the group consisting of ibuprofen and salts thereof, in which the solid composition does not include a solid composition comprising levocetirizine or loratadine.

The present invention relates to solid compositions. The present invention addresses the problem of providing a solid composition containing ibuprofen in which changes in properties are suppressed. [Solution] A solid composition comprising the following components: (A) ibuprofen; (B) at least one substance selected from the group consisting of tepiperidine and salts thereof; and (C) at least one compound selected from the group consisting of tranexamic acid and salts thereof, in which the solid composition does not include a solid composition containing levocetirizine or loratadine.

Described herein is a method of administering injectable cetirizine or levocetirizine to treat acute urticaria, with or without concomitant angioedema, without life-threatening airway swelling by intravenously injecting a human patient within minutes to hours of developing acute urticaria in an emergency department or clinic with a therapeutically effective amount of an injectable cetirizine or levocetirizine composition. In the method, the injectable cetirizine or levocetirizine is the only treatment administered in the emergency department or clinic. The method can include determining, by the patient, a patient rated pruritus severity score at a 1 hour assessment, and optionally at a 2 hours assessment, and a physician discharging the human patient after 1.7±0.9 hours in the emergency department or clinic, wherein the human patient has a patient rated pruritus severity score reduction of at least 1 unit and baseline sedation at the time of discharge.

Certain embodiments described herein include methods and formulations for treating or preventing symptoms and conditions associated with sepsis. The methods and formulations include, but are not limited to, methods and formulations for delivering effective concentrations of levocetirizine and montelukast to a patient in need. The methods and formulations can comprise conventional and / or modified-release elements, providing for drug delivery to the patient.

The application discloses a preparation method and application of a levocetirizine hydrochloride intermediate, and a high-quality levocetirizine hydrochloride intermediate is obtained. The method comprises the following steps: taking di(2-chloroethyl)amine as a raw material, performing a formate esterification reaction, performing a (R)-(4-chlorophenyl)(phenyl)methylamine cyclization, and performing reduction to obtain the levocetirizine hydrochloride intermediate, and then performing a substitution reaction to generate the levocetirizine hydrochloride. The method is simple in operation, has less by-product, has a high yield, is easy in raw material obtaining, is low in cost, and is suitable for industrial large-scale production.

The invention discloses a levocetirizine hydrochloride eye drop composition as well as a preparation method and application thereof, and belongs to the field of pharmaceutical preparations. The composition is prepared from levocetirizine hydrochloride, polyvinyl alcohol, povidone K30, sodium chloride, sodium benzoate, sodium hydroxide, hydrochloric acid and water, discomfort such as eye dryness caused by allergic conjunctivitis is remarkably relieved, and irritation caused by preservative sodium benzoate in multi-dose eye drops is reduced. The preparation method of the composition comprises the following steps: dissolving polyvinyl alcohol with a first part of water to obtain a product 1; dissolving povidone K30, sodium chloride and sodium benzoate with a second part of water, adjusting the pH value with sodium hydroxide and / or hydrochloric acid, and adding levocetirizine hydrochloride to obtain a product 2; and finally, adding the product 1 into the product 2, and supplementing water to the total amount. The composition is mainly used for treating eye itching related to allergic conjunctivitis. The levocetirizine hydrochloride eye drops provided by the invention do not contain antioxidants and buffering agents, and are non-irritant and good in stability.

The invention provides a method for detecting parachlorobenzhydryl piperazine in levocetirizine hydrochloride particles. The method comprises the following steps: determining related substances in the levocetirizine hydrochloride particles by adopting a high performance liquid chromatography, a chromatographic column in the method is a chromatographic column taking octadecylsilane chemically bonded silica as a filling agent; a mobile phase is a mixed solution of a mobile phase A and a mobile phase B, a phosphoric acid aqueous solution is taken as the mobile phase A, an acetonitrile-methanol solution is taken as the mobile phase B, linear gradient elution is adopted, the concentration of the mobile phase A is adjusted within the range of 75% v / v-20% v / v, the concentration of the mobile phase B is adjusted within the range of 80% v / v-25% v / v, and the elution time is 60-70 min. The levocetirizine hydrochloride and related substances (impurity A: parachlorobenzhydryl piperazine) can be accurately and reliably separated and determined well, so that the quality control of the levocetirizine hydrochloride particles is effectively realized, and the pharmaceutical safety is improved.

The present invention relates to an oral solution of levocetirizine hydrochloride. Specifically, the present invention provides a liquid preparation of levocetirizine hydrochloride, and the liquid preparation of levocetirizine hydrochloride includes glycerol monolaurate, propylene glycol, polyethylene glycol 400, a pH regulator, and water. It may also contain one flavoring agent selected from xylitol, sucrose, sucralose, glucose, aspartame, steviol glycoside, or sodium saccharin. The oral solution of levocetirizine hydrochloride of the present invention has excellent taste and stability.

To provide a solid composition containing ibuprofen, the change in properties of which is suppressed. The present invention relates to a composition comprising: (A) Ibuprofen, (B) at least one selected from the group consisting of tipepidine and salts thereof, and (C) at least one selected from the group consisting of tranexamic acid and salts thereof A solid composition comprising, but excluding a solid composition comprising levocetirizine or loratadine.

To provide a solid composition containing at least one selected from the group consisting of tipepidine and salts thereof and at least one selected from the group consisting of tranexamic acid and salts thereof, which has improved dissolution properties of tipepidine. The present invention relates to a composition comprising the following components: (A) at least one selected from the group consisting of tipepidine and salts thereof, (B) at least one selected from the group consisting of tranexamic acid and salts thereof, and (C) at least one selected from the group consisting of ibuprofen and salts thereof A solid composition comprising, but excluding a solid composition comprising levocetirizine or loratadine.

1. Name of the product of this design: Packaging box (levocetirizine hydrochloride oral drops). 2. Purpose of this product with design: This product with design is used to pack various items. 3. The key design point of this design product lies in the combination of shape and pattern. 4. The picture or photo that best illustrates the design points: Stereoscopic drawing 1.

The invention provides a preparation method of levocetirizine hydrochloride granules, which comprises the following steps: S1, mixing sodium alginate with deionized water, sodium hydroxymethyl starch, hydroxypropyl methylcellulose and maltitol, and performing ultrasonic oscillation and uniform mixing to obtain a mixed solution; s2, uniformly mixing levocetirizine hydrochloride with hydroxypropyl-beta-cyclodextrin, sodium bicarbonate and lactose to obtain a mixed material A; s3, uniformly mixing the mixed solution with the mixed material A to obtain a mixed material B; and S4, carrying out wet granulation, drying and dry granulation on the mixed material B by using an oscillating granulator, mixing with sucralose, and subpackaging to obtain the levocetirizine hydrochloride granules. Through a specific raw material formula and control of preparation process conditions, the particle uniformity of the levocetirizine hydrochloride particle medicine can be improved, the production efficiency can be improved, meanwhile, the stability of the levocetirizine hydrochloride medicine in the storage period can be improved, the product quality is not obviously changed, and the levocetirizine hydrochloride particle medicine has a good application prospect.