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Levocetirizine hydrochloride syrup and preparation method

A technology of levocetirizine hydrochloride and syrup, which is applied in pharmaceutical formulations, drug delivery, respiratory diseases and other directions, can solve problems such as poor taste and poor clinical compliance, and achieves high industrial production feasibility and low production cost. , the effect of sweet and sour

Inactive Publication Date: 2014-06-18
AVENTIS PHARMA HAINAN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

CN1418630A discloses a preparation method of oral liquid, wherein strawberry flavor essence is added to correct the taste, but because levocetirizine hydrochloride has a strong bitter taste, the mouthfeel of the prepared solution preparation is not good, especially for children patients. , poor clinical compliance

Method used

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  • Levocetirizine hydrochloride syrup and preparation method
  • Levocetirizine hydrochloride syrup and preparation method
  • Levocetirizine hydrochloride syrup and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Example 1 Levocetirizine Hydrochloride Syrup

[0024] This embodiment is in the form of a syrup. (measured per 1000ml)

[0025] Prescription 1:

[0026]

[0027] preparation:

[0028] (1) Preparation of simple syrup (1000ml): Take 450ml of water, boil, add 850g of syrup base, stir to dissolve; continue to heat to 100°C, filter with absorbent cotton, add an appropriate amount of hot water from the filter, and let it cool to room temperature When the time is 1000ml, stir well, that is.

[0029] (2) Add the raw material drug and water-soluble excipients to the simple syrup of the prescription amount, stir and mix to obtain solution I; add water-insoluble excipients to a less polar solvent, and stir to obtain solution II. Mix solution I and solution II evenly, adjust the pH to 5.0, and add water to make up to 1000ml.

[0030]

Embodiment 2

[0031] Example 2 Levocetirizine Hydrochloride Syrup

[0032] This embodiment is in the form of a syrup. (measured per 1000ml)

[0033]

[0034] The preparation method is the same as in Example 1.

[0035]

Embodiment 3

[0036] Example 3 Levocetirizine Hydrochloride Syrup

[0037] This embodiment is in the form of a syrup. (measured per 1000ml)

[0038]

[0039] The preparation method is the same as in Example 1.

[0040]

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Abstract

The invention belongs to the field of medicinal preparations and discloses levocetirizine hydrochloride syrup and a preparation method. The levocetirizine hydrochloride syrup and the preparation method have the advantages that the bitter taste of the levocetirizine hydrochloride is covered, the adaptability of clinical medicines is improved, the treating effect is more ideal, and the preparation process is simple and is high in reliability.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a syrup containing levocetirizine hydrochloride antiallergic medicine and a preparation method. Background technique [0002] Syrup refers to a concentrated sucrose aqueous solution containing medicinal or aromatic substances for oral use. Sorbitol can replace sucrose to prepare sugar-free syrup. Concentrated sucrose and flavoring agents can cover up the bad smell of drugs with poor taste and improve the taste, especially popular with children. It is generally prepared by dissolution method or mixing method. Dissolution methods are generally divided into hot-melt method and cold-melt method, both of which have their limitations. If the hot melt method is heated for too long, the invert sugar will increase, the color of the syrup will deepen, and it is not suitable for drugs that are unstable to heat, while the cold melt method will take a long time to heat and easil...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/495A61P37/08A61P11/02A61P17/00A61P11/06
Inventor 王凯翟富民徐烨郭夏
Owner AVENTIS PHARMA HAINAN
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