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Pharmaceutical composition for treating acute urticaria

A technology for urticaria and a composition is applied in the field of medicines for the treatment of urticaria, can solve problems such as high medical expenses, poor curative effect, and patient dissatisfaction, achieves high cure rate and effective rate, low toxic and side effects, and increases drug use The effect of compliance

Inactive Publication Date: 2014-02-19
李伟丽
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The curative effect of the current technology is poor, and the repeated attacks after treatment make the patients dissatisfied, which not only brings a lot of pain to the patients, but also brings high medical expenses.

Method used

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  • Pharmaceutical composition for treating acute urticaria
  • Pharmaceutical composition for treating acute urticaria

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Example 1 Common tablet

[0039] Prescription: 15g of levocetirizine, 0.75g of triptolide, 250g of microcrystalline cellulose, 20g of lactose, appropriate amount of 10% starch slurry, and 0.8g of magnesium stearate.

[0040] Preparation process: Weigh the prescribed amount of levocetirizine, triptolide, microcrystalline cellulose, and lactose and mix evenly. In addition, add an appropriate amount of 10% starch slurry to the mixed powder, mix evenly, make soft materials, pass through a 18-mesh nylon sieve to make wet granules, and dry at about 60°C. The moisture content of dry granules should be controlled below 1.5%. Sieve through a 20-mesh sieve, mix with magnesium stearate, and press into tablets.

Embodiment 2

[0041] Example 2 Common tablet

[0042] Prescription: 10g of levocetirizine, 200g of triptolide, 140g of starch, 20g of dextrin, appropriate amount of 50% ethanol, and 1.0g of magnesium stearate.

[0043] Preparation process: Weigh the prescribed amount of levocetirizine, triptolide, starch and dextrin and mix evenly. In addition, add an appropriate amount of 50% ethanol to the mixed powder, mix evenly, make a soft material, pass through a 18-mesh nylon sieve to make wet granules, and dry at about 60°C. The moisture content of the dry granules should be controlled below 1.5%. Sieve through a 20-mesh sieve, mix with magnesium stearate, and press into tablets.

Embodiment 3

[0044] Embodiment 3 Dispersible tablets

[0045] Prescription: Levocetirizine 10g, triptolide 2.5g, croscarmellose sodium 10g, microcrystalline cellulose 150g, polyvinylpyrrolidone 5.5g, 5% PVP 60% ethanol solution, micropowder silica gel 5g .

[0046] Preparation process: Weigh levocetirizine and triptolide according to the prescription quantity, use microcrystalline cellulose as filler, croscarmellose sodium and polyvinylpyrrolidone as disintegrants, 5% PVP 60% The ethanol solution is used as the binder, the micropowdered silica gel is used as the flow aid, and it is granulated by a fluidized bed in one step, and then compressed into tablets.

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PUM

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Abstract

The invention discloses pharmaceutical composition for treating acute urticaria and an application of the pharmaceutical composition to preparation of drugs for preventing or treating the acute urticaria, and aims at overcoming the defect that drugs for treating the acute urticaria are poor in effect and non-sustainable in action at present, the pharmaceutical composition for preventing or treating the acute urticaria is low in treatment cost, convenient to take by a patient, quick in curative effect and free of side effects and comprises levocetirizine and triptolide. The pharmaceutical composition has a good treatment effect in treating the acute urticaria and obvious clinical promotional values.

Description

technical field [0001] The invention belongs to the technical field of medicines for treating urticaria, in particular to a pharmaceutical composition for treating acute urticaria. Background technique [0002] Urticaria, commonly known as wheal, wheal, wheal, wheal, is a common skin disease. The skin rash of this disease is similar to the skin damage caused by people who have been exposed to plant nettles, so it is called urticaria. The characteristics of this disease are: generalized wheal-type skin lesions all over the body, rashes come and go quickly, subside without leaving traces, feel itchy, and may be accompanied by systemic symptoms and visceral damage, such as fever, abdominal pain, diarrhea or other systemic symptoms. Divided into acute urticaria, chronic urticaria, angioneurotic edema, and papular urticaria, etc., often lingering for many years without healing; Causes: certain foods, drugs, infections, pollen and other inhaled substances (house dust, animal dand...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/585A61P17/00A61P37/08A61K31/495
Inventor 刘学键
Owner 李伟丽
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