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Use of levocetirizine and montelukast in the treatment of traumatic injury

A levocetirizine, traumatic technology, applied in the field of use of levocetirizine and montelukast in the treatment of traumatic injuries, can solve problems such as increasing the risk of diabetes

Inactive Publication Date: 2016-04-20
INFLAMMATORY RESPONSE RES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

More recently, however, consensus has been that high doses of steroids increase the risk of secondary infections, gastric ulcers, electrolyte disturbances, fluid retention, and steroid-induced diabetes

Method used

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  • Use of levocetirizine and montelukast in the treatment of traumatic injury
  • Use of levocetirizine and montelukast in the treatment of traumatic injury
  • Use of levocetirizine and montelukast in the treatment of traumatic injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0160] Case Study: 18-Year-Old Male Trauma Patient with Brain, Lung, Facial, and Liver Injuries

[0161] patient

CR

[0162] DOB

June 14, 1993

age

18

[0163] The patient was an 18-year-old male who was examined and evaluated in the Santa Barbara Cottage Hospital Surgical ICU at approximately midnight on February 17, 2012 after falling off a cliff in Isla Vista, California. The height of the fall is estimated at 30 to 35 feet. His Glasgow Comascale on admission was 7 / 15, reflecting a greater than 50% probability of death. Contributing Factors: Consumption of 10 alcoholic beverages (BAC.252g / dL) between 9PM and midnight.

[0164] Social History: Student at the University of California, Santa Barbara

[0165] Significant pre-existing medical problems: None

[0166] relevant physical examination

[0167] At the consultation (Saturday, February 18, 2012, 10:30 to 13:15 hours), the CR was intubated and sedated on a ventilator. ...

Embodiment 2

[0215] Case study: 19-year-old male with aspiration pneumonia / lung contusion / closed head injury

[0216] patient

EL

DOB

August 14, 1993

age

19

[0217] The patient was a 19-year-old male who fell 20 feet from a building at 01:00 hours on Sunday, October 28, 2012 in Isla Vista, California, resulting in a significant mid-facial fracture, Lung contusions, inhalation and blunt head injuries. Glasgow Coma Scale as an index of consciousness at the scene was 3 / 15 (normal 15 / 15). It is unable to move spontaneously and appears to have severe facial trauma. Subsequently, the EL was transported by ambulance to the Santa Barbara Country Hospital Emergency Department for evaluation and admission. He was intubated on a ventilator in the SICU (Surgical Intensive Care Unit) for the initial ENT evaluation. Ventilator settings were as follows: FIO260% (inspired oxygen), PEEP5cmH2O, tidal volume 500ml, SMIV, pressure support 10cmH2O.

[0218] Vital si...

Embodiment 3

[0258] Prophetic Study: Patients with Mild, Moderate, and Severe Adult Respiratory Distress Syndrome.

[0259] In this study, patients with mild adult respiratory distress syndrome (ARDS), patients with moderate ARDS and patients with severe ARDS were administered a combination of levocetirizine and montelukast. The following specific parameters were monitored: length of hospital stay, days on ventilator (intubation), mortality, and secondary infections. All patients were given a combination of levocetirizine and montelukast on admission. Given the inherent safety of the molecule and the synergistic manner in which multiple pathways are blocked during the acute or innate phase response to trauma, an initial cohort of 20 patients was compared with retrospective data collected from patients treated with existing regimens .

[0260] Expected results include the following:

[0261] Reduced time to intubation when compared to patients exhibiting the same or similar degree of i...

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Abstract

The embodiments described herein include methods and formulations for treating lung and brain injury. The methods and formulations include, but are not limited to, methods and formulations for delivering effective concentrations of levocetirizine and montelukast to a patient in need. The methods and formulations can comprise conventional and / or modified-release elements, providing for drug delivery to the patient.

Description

[0001] Cross References to Related Applications [0002] This patent application claims the benefit of priority to US Provisional Patent Application No. 61 / 780,336, filed March 13, 2013. The foregoing applications are hereby incorporated by reference in their entirety for all purposes. Background technique [0003] In 2011, an expert panel (initiated by the European Society of Intensive Care Medicine, supported by the American Thoracic Society and the Society of Critical Care Medicine) reviewed the criteria for acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). , ARDS) defines the Berlin definition (BerlinDefinition). There are currently three stages: mild, moderate, and severe, with corresponding increases in mortality and, among survivors, median durations of mechanical ventilation). As shown in the Berlin Definition of Acute Respiratory Distress Syndrome (Table VII), the classification of ARDS is based in part on the degree of hypoxemia determined by ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P29/00
CPCA61K38/14A61K45/06A61K31/407A61K31/424A61K31/43A61K31/431A61K31/47A61K31/496A61K31/505A61K31/5383A61K31/546A61K31/635A61K31/65A61K31/7052A61K31/7056A61K31/495A61P11/00A61P25/00A61P29/00A61P31/04A61P43/00A61P9/10A61K2300/00A61K31/5575A61K31/558
Inventor 布鲁斯·钱德勒·梅
Owner INFLAMMATORY RESPONSE RES
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