Method for testing related substances of levocetirizine hydrochloride intermediate

A technology of levocetirizine hydrochloride and a determination method, applied in the field of analytical chemistry, can solve the problems of incomplete removal of impurities, influence on the purity and quality of drugs, etc., and achieve the effect of ensuring quality and controllable quality
CN104569269AInactive Publication Date: 2015-04-29AVENTIS PHARMA HAINAN
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
AVENTIS PHARMA HAINAN
Publication Date
2015-04-29
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention belongs to the field of analytical chemistry, and discloses a method for separately testing a levocetirizine hydrochloride intermediate and related substances of the levocetirizine hydrochloride intermediate by liquid chromatography. The method comprises the following steps: a chromatographic column taking octadecylsilane chemically bonded silica as a filler uses a certain proportion of buffer salt solution-organic phase as a mobile phase to quantificationally test the content of the levocetirizine hydrochloride intermediate and the content of the related substances of levocetirizine hydrochloride intermediate, so that the quality of the levocetirizine hydrochloride intermediate is effectively controlled, and the controllable quality of levocetirizine hydrochloride is ensured. The method is high in specificity and accuracy, and simple and convenient to operate.
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Description

technical field

[0001] The invention belongs to the field of analytical chemistry, in particular to a method for separating and measuring levocetirizine hydrochloride intermediates and related substances by liquid chromatography. Background technique

[0002] Levocetirizine hydrochloride is used to relieve allergic symptoms of allergic diseases, clinically used to treat allergic rhinitis, urticaria, angioedema and other skin and mucous membrane allergic diseases, and also used to reduce allergic symptoms of colds . The chemical name of the intermediate of levocetirizine hydrochloride is 2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethanol, and the molecular formula is C 19 h 23 ClN 2 O. The structural formula of levocetirizine hydrochloride intermediate is:

[0003] .

[0004] In the process of synthesizing this compound, some important intermediates may affect the purity and quality of the drug due to incomplete removal. For the synthesis of levocetirizine hy...

Claims

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