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Compound medicine composition for treating urticaria

A composition and technology of urticaria, applied in the field of pharmaceutical preparations, can solve the problems of not being able to meet the requirements of clinical medication, small scope of application, large amount of active ingredient levocetirizine, etc.

Pending Publication Date: 2022-04-29
JIANGSU ALICORN PHARMATECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] There are not many patent documents for levocetirizine injection disclosed at present. Both WO2011003074 and CN107961215A disclose levocetirizine injection containing sodium chloride, but the active ingredient levocetirizine injection in unilateral The amount of tirizine used is too large, the content is unstable during storage, and more related substances are likely to be produced. The scope of application is small, and it still cannot meet the needs of clinical medication.
[0012] Therefore, it is of great clinical significance to develop a compound preparation of levocetirizine hydrochloride and BCG polysaccharide nucleic acid, and there is no patent report and related preparations of levocetirizine hydrochloride and BCG polysaccharide nucleic acid composition and its related preparations abroad. product launch

Method used

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  • Compound medicine composition for treating urticaria
  • Compound medicine composition for treating urticaria
  • Compound medicine composition for treating urticaria

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preparation example Construction

[0039] The preparation of embodiment 1~15 compound injection

[0040] Table 2 Prescription of Compound Injection

[0041]

[0042] Preparation Process:

[0043] Step 1: Weigh the prescribed amount of levocetirizine, pharmaceutically acceptable salt, and BCG polysaccharide nucleic acid respectively, put them into the batching tank, add water for injection to 80-90% of the total amount, and maintain the liquid temperature at 40°C Stir until it is completely dissolved, then add the prescribed amount of osmotic pressure regulator, and stir for 30 minutes until the liquid is clear;

[0044] Step 2: add a pH regulator to adjust the pH value of the medicinal solution, add water for injection to the full amount, continue to stir, and leave standstill;

[0045] Step 3: Filter the medicinal solution in step 2 through a 0.22 μm microporous membrane, fill, seal, and autoclave at 121° C. for 10 minutes to prepare 1 mL of sterilized small-volume injection.

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Abstract

The compound pharmaceutical composition for treating urticaria comprises two active pharmaceutical ingredients, namely levocetirizine hydrochloride and bacillus calmette-guerin polysaccharide nucleic acid, and the weight ratio of levocetirizine hydrochloride to bacillus calmette-guerin polysaccharide nucleic acid is (5-25): 1. Tests prove that the pharmaceutical composition disclosed by the invention has a good curative effect on urticaria caused by various reasons, the efficacy of the composition is obviously superior to that of levocetirizine hydrochloride or an immunomodulator when the levocetirizine hydrochloride or the immunomodulator is independently applied, and the pharmaceutical composition shows very excellent storage stability.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to a compound pharmaceutical composition for treating urticaria, in particular to a pharmaceutical composition comprising levocetirizine and BCG polysaccharide nucleic acid. Background technique [0002] Urticaria, commonly known as wheal, wheal, wheal, wheal, is a common skin disease. The skin rash of this disease is similar to the skin damage caused by people who have been exposed to plant nettles, so it is called urticaria. The characteristics of this disease are: generalized wheal-type skin lesions all over the body, rashes come and go quickly, subside without leaving traces, feel itchy, and may be accompanied by systemic symptoms and visceral damage, such as fever, abdominal pain, diarrhea or other systemic symptoms. Divided into acute urticaria, chronic urticaria, angioedema and papular urticaria. [0003] Chronic urticaria is a common, frequently-occurring and recur...

Claims

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Application Information

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IPC IPC(8): A61K31/715A61K47/02A61K47/10A61K47/12A61K47/26A61P17/00A61P37/08A61K9/08A61K31/495
CPCA61K31/495A61K31/715A61K9/08A61K9/0019A61K47/26A61K47/10A61K47/12A61K47/02A61P37/08A61P17/00A61K2300/00
Inventor 渠文静董海红陆平波
Owner JIANGSU ALICORN PHARMATECH CO LTD
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