Pharmaceutical composition for treating acetyl cholinergic urticaria

A technology of acetylcholine and composition, which is applied in the field of medicines for the treatment of urticaria, and achieves the effects of prolonging maintenance time, improving onset time, and increasing medication compliance

Active Publication Date: 2014-04-02
启东市清汉农副产品专业合作社
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, Western medicine has no specific treatment for urticaria. Most of them use oral antihistamines and corticosteroids for temporary suppression, such as oral western medicines, oral hormones, external solution lotions, emulsions, mud creams, oils, ointments, etc. Emulsions, varnishes, tinctures and plasters, etc.

Method used

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  • Pharmaceutical composition for treating acetyl cholinergic urticaria
  • Pharmaceutical composition for treating acetyl cholinergic urticaria

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Example 1 Common tablet

[0043] Prescription: 15g of levocetirizine, 0.75g of promethazine, 250g of microcrystalline cellulose, 20g of lactose, appropriate amount of 10% starch slurry, and 0.8g of magnesium stearate.

[0044] Preparation process: Weigh the prescribed amount of levocetirizine, iprocene, microcrystalline cellulose, and lactose and mix evenly. In addition, add an appropriate amount of 10% starch slurry to the mixed powder, mix evenly, make soft materials, pass through a 18-mesh nylon sieve to make wet granules, and dry at about 60°C. The moisture content of dry granules should be controlled below 1.5%. Sieve through a 20-mesh sieve, mix with magnesium stearate, and press into tablets.

Embodiment 2

[0045] Example 2 Common tablet

[0046] Prescription: 10g of levocetirizine, 200g of promethazine, 140g of starch, 20g of dextrin, appropriate amount of 50% ethanol, and 1.0g of magnesium stearate.

[0047] Preparation process: Weigh the prescribed amount of levocetirizine, iprocene, starch and dextrin and mix evenly. In addition, add an appropriate amount of 50% ethanol to the mixed powder, mix evenly, make a soft material, pass through a 18-mesh nylon sieve to make wet granules, and dry at about 60°C. The moisture content of the dry granules should be controlled below 1.5%. Sieve through a 20-mesh sieve, mix with magnesium stearate, and press into tablets.

Embodiment 3

[0048] Embodiment 3 Dispersible tablets

[0049] Prescription: 10g of levocetirizine, 2.5g of promethazine, 10g of croscarmellose sodium, 150g of microcrystalline cellulose, 5.5g of polyvinylpyrrolidone, an appropriate amount of 5% PVP 60% ethanol solution, micronized silica gel 5g.

[0050] Preparation process: Weigh levocetirizine and iproquinone according to the prescription quantity, use microcrystalline cellulose as filler, croscarmellose sodium and polyvinylpyrrolidone as disintegrants, 5% PVP 60 The % ethanol solution is used as a binder, the micropowdered silica gel is used as a flow aid, and it is granulated by a fluidized bed in one step, and then compressed into tablets.

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PUM

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Abstract

The invention belongs to the technical field of treatment medicines for urticaria, and specially relates to a pharmaceutical composition for treating acetyl cholinergic urticaria and application of the pharmaceutical composition in preparation of a medicine for preventing or treating the acetyl cholinergic urticaria, aiming at overcoming the shortage that the existing medicine for treating the acetyl cholinergic urticaria has poor treatment effect and cannot act for a long time in the prior art. The pharmaceutical composition for treating or preventing the acetyl cholinergic urticaria consists of levocetirizine and isopropylidene sedoheptuiosan. The pharmaceutical composition shows a good effect on treatment of acetyl cholinergic urticaria and is remarkably worthy of clinical popularization.

Description

technical field [0001] The invention relates to the technical field of medicines for treating urticaria, in particular to a pharmaceutical composition for treating acetylcholine urticaria. Background technique [0002] Urticaria, commonly known as wheal, wheal, wheal, wheal, is a common skin disease. The skin rash of this disease is similar to the skin damage caused by people who have been exposed to plant nettles, so it is called urticaria. The characteristics of this disease are: generalized wheal-type skin lesions all over the body, rashes come and go quickly, subside without leaving traces, feel itchy, and may be accompanied by systemic symptoms and visceral damage, such as fever, abdominal pain, diarrhea or other systemic symptoms. Divided into acetylcholine urticaria, chronic urticaria, angioedema and papular urticaria, etc., often lingering for many years without healing. [0003] Acetylcholine urticaria is a type of urticaria. In addition to no rash, only acupunctu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P17/00A61K31/495
Inventor 刘学键
Owner 启东市清汉农副产品专业合作社
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