Use of pharmaceutical composition in preparation of medicine for treating acetylcholine urticaria

A technology of acetylcholine and composition, which is applied in the field of medicines for the treatment of urticaria, and achieves the effects of low toxic and side effects, prolonging maintenance time, and increasing medication compliance

Inactive Publication Date: 2019-01-18
临沂高新区金迪科技信息服务中心
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, Western medicine has no specific treatment for urticaria. Most of them use oral antihistamines and corticosteroids for temporary suppression, s...

Method used

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  • Use of pharmaceutical composition in preparation of medicine for treating acetylcholine urticaria

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Example 1 Common tablet

[0043] Prescription: 15g of levocetirizine, 0.75g of promethazine, 250g of microcrystalline cellulose, 20g of lactose, appropriate amount of 10% starch slurry, and 0.8g of magnesium stearate.

[0044] Preparation process: Weigh the prescribed amount of levocetirizine, iprocene, microcrystalline cellulose, and lactose and mix evenly. In addition, add an appropriate amount of 10% starch slurry to the mixed powder, mix evenly, make soft materials, pass through a 18-mesh nylon sieve to make wet granules, and dry at about 60°C. The moisture content of dry granules should be controlled below 1.5%. Sieve through a 20-mesh sieve, mix with magnesium stearate, and press into tablets.

Embodiment 2

[0045] Example 2 Common tablet

[0046] Prescription: 10g of levocetirizine, 200g of promethazine, 140g of starch, 20g of dextrin, appropriate amount of 50% ethanol, and 1.0g of magnesium stearate.

[0047] Preparation process: Weigh the prescribed amount of levocetirizine, iprocene, starch and dextrin and mix evenly. In addition, add an appropriate amount of 50% ethanol to the mixed powder, mix evenly, make a soft material, pass through a 18-mesh nylon sieve to make wet granules, and dry at about 60°C. The moisture content of the dry granules should be controlled below 1.5%. Sieve through a 20-mesh sieve, mix with magnesium stearate, and press into tablets.

Embodiment 3

[0048] Embodiment 3 Dispersible tablets

[0049] Prescription: 10g of levocetirizine, 2.5g of promethazine, 10g of croscarmellose sodium, 150g of microcrystalline cellulose, 5.5g of polyvinylpyrrolidone, an appropriate amount of 5% PVP 60% ethanol solution, micronized silica gel 5g.

[0050] Preparation process: Weigh levocetirizine and iproquinone according to the prescription quantity, use microcrystalline cellulose as filler, croscarmellose sodium and polyvinylpyrrolidone as disintegrants, 5% PVP 60 The % ethanol solution is used as a binder, the micropowdered silica gel is used as a flow aid, and it is granulated by a fluidized bed in one step, and then compressed into tablets.

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PUM

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Abstract

The invention belongs to the technical field of medicines for treating urticaria, in particular to a pharmaceutical composition for treating acetylcholine urticaria and use of the pharmaceutical composition in preventing or treating acetylcholine urticaria. A Chinese medicinal composition for treat or preventing acetylcholine urticaria is compose of levocetirizine and isopropylenic anhydride. ThatChinese medicinal composition comprises levocetirizine and isopropylenic anhydride. The Chinese medicinal composition has good therapeutic effect on acetylcholine urticaria, and has obvious clinicalpopularization value.

Description

technical field [0001] The invention relates to the technical field of medicines for treating urticaria, in particular to a pharmaceutical composition for treating acetylcholine urticaria. Background technique [0002] Urticaria, commonly known as wheal, wheal, wheal, wheal, is a common skin disease. The skin rash of this disease is similar to the skin damage caused by people who have been exposed to plant nettles, so it is called urticaria. The characteristics of this disease are: generalized wheal-type skin lesions all over the body, rashes come and go quickly, subside without leaving traces, feel itchy, and may be accompanied by systemic symptoms and visceral damage, such as fever, abdominal pain, diarrhea or other systemic symptoms. Divided into acetylcholine urticaria, chronic urticaria, angioedema and papular urticaria, etc., often lingering for many years without healing. [0003] Acetylcholine urticaria is a type of urticaria. In addition to no rash, only acupunctu...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K31/495A61P37/08
CPCA61K31/7048A61K31/495A61P37/08A61K2300/00
Inventor 朱芳玉
Owner 临沂高新区金迪科技信息服务中心
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