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Xiaobuling vaginal expansion suppository and preparation method thereof

A technology of vaginal expansive suppository and anti-repellent, which is applied in the fields of suppository delivery, pharmaceutical formulation, and testing of pharmaceutical preparations. It can solve the problems of easy-to-contaminate clothing, povidone-iodine is volatile, and difficult to clean, so as to avoid secondary infection, Expand the administration area and reduce the effect of mutual interference

Active Publication Date: 2017-12-12
哈尔滨田美药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although the existing Xiaobuling suppository has good bactericidal and contraceptive effects, the povidone-iodine in the Xiaobuling composition is volatile, and nonoxynol belongs to liquid form, which causes the suppository made to be unstable; and the liquid After the form of nonoxynol ether is made into suppositories, it is not conducive to its release and dissolution, resulting in a decrease in its activity
In addition, ordinary Xiaobuling suppository also has technical problems such as not being easy to clean and easily contaminating clothes; the contact surface between the active ingredient and the human body is small, resulting in insufficient absorption and not exerting the best curative effect of the prescription.

Method used

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  • Xiaobuling vaginal expansion suppository and preparation method thereof
  • Xiaobuling vaginal expansion suppository and preparation method thereof
  • Xiaobuling vaginal expansion suppository and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078]

[0079] Preparation:

[0080] 1) Preparation of drug-containing matrix:

[0081] a. heat and melt tallow tallow, Tween 60 and polyethylene glycol 400 in a water bath to obtain a melt;

[0082] b. adding nonoxynol and povidone-iodine to the melt obtained in step a, and mixing uniformly to obtain a drug-containing matrix;

[0083] 2) Preparation of expansive suppository: Pour the drug-containing matrix into a suppository mold, insert a tampon, cool and shape, and make 100 rod-shaped suppositories, each weighing about 1.8 g.

Embodiment 2

[0085]

[0086] Preparation:

[0087] 1) Preparation of drug-containing matrix:

[0088] a. Semi-synthetic fatty acid ester and propylene glycol stearate are placed in a water bath for heating and melting to obtain a melt;

[0089] b. mixing povidone iodine, nonoxynol, calcium stearoyl lactylate, gellan gum and heparin sodium evenly to prepare a mixture;

[0090] c. adding the mixture obtained in step b to the melt obtained in step a, and mixing evenly to obtain a drug-containing matrix;

[0091] 2) Preparation of expansive suppository: Pour the drug-containing matrix into a suppository mold, insert a tampon, cool and shape, and make 100 duckbill-shaped suppositories, each weighing about 5.0 g.

Embodiment 3

[0093]

[0094]

[0095] Preparation method: make 100 conical suppositories by the method of Example 2, each weighing about 2.9g.

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Abstract

The invention relates to a Xiaobuling vaginal expansion suppository and its preparation method and detection method. The expansion suppository includes a drug-containing matrix and an expansion carrier formed by nonoxynol ether, povidone iodine and the matrix; the drug-containing matrix also includes ester Calcium acyl lactate, gellan gum and heparin sodium, etc.; the expansion suppository has high stability, uniform dispersion of active ingredients, and less vaginal irritation; and the provided Xiaobuling vaginal expansion suppository adopts six original leading It has the beneficial effects of preventing the outflow of medicinal liquid, quick onset of action, and prevention of secondary infection.

Description

technical field [0001] The invention belongs to the field of vaginal suppositories, in particular to a Xiaobuling vaginal expansion suppository and a preparation method and detection method thereof. Background technique [0002] Vaginal infection, unsatisfactory condom acceptance rate and unmarried pregnancy have become indisputable facts in today's society, seriously affecting the reproductive health of the general public. In order to solve the problems existing in the prior art, the main means adopted include developing products for preventing and treating vaginal infections and developing external contraceptive products for killing sperm and preventing and treating vaginal infections. Xiaobuling suppository is a product developed for killing sperm and preventing and treating vaginal infection; in addition, CN1415307 also discloses a Xiaobuling vaginal suppository, which has a good bactericidal effect and can achieve contraceptive effect. [0003] Although the existing Xi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/79A61K9/02A61K47/10A61K47/36G01N33/15G01N5/04A61P15/02A61P31/04A61P15/16A61P15/18A61K31/075
Inventor 邱学良邱明世
Owner 哈尔滨田美药业股份有限公司
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