Chenopodiumformosanum Koidz (CFK) extract with anti-aging, whitening, anti-allergic and cell repair functions

An extract, anti-allergic technology, used in allergic diseases, skin care preparations, cosmetics, etc., can solve the problems of cytotoxicity, no whitening and anti-aging, damage to melanocytes, etc.

Pending Publication Date: 2018-11-23
CHIA NAN UNIV PHARMACY & SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the past, traditional Chinese medicine’s knowledge of red quinoa was only an edible plant, which has anti-oxidation and anti-inflammation effects. Its whitening and anti-aging functions have not been discovered. However, the whitening ingredients contained in commercially available products such as: vitamin C (Vitamin C) , Hydroquinone, Acelaic acid and Arbutin, although they have significant effects, but some whitening agents can directly destroy melanocytes, which will cause cell toxicity

Method used

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  • Chenopodiumformosanum Koidz (CFK) extract with anti-aging, whitening, anti-allergic and cell repair functions
  • Chenopodiumformosanum Koidz (CFK) extract with anti-aging, whitening, anti-allergic and cell repair functions
  • Chenopodiumformosanum Koidz (CFK) extract with anti-aging, whitening, anti-allergic and cell repair functions

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039]Embodiment 1: the water extraction of red quinoa

[0040] Red quinoa was purchased from the local farmers association in Chishang Township, Taitung County. After the red quinoa is smashed, 100 grams of the pounded extract and 900 grams of water are mixed in a double-ground round-bottomed flask. Then, put in a heating bag and mix the extract and water under reflux at 80 to 90° C. for about 3 hours. After the time is up, the round-bottomed flask with double grinding mouths is cooled, and then the mixture is filtered with a Buchner funnel and an air pump to obtain a clear filtrate. Finally, first concentrate the filtrate under reduced pressure, then freeze and concentrate the filtrate for about one day at -80°C, and then freeze-dry it in a vacuum bottle to obtain the final product water extract CFKW (extraction rate is about 7.8%, 100 grams of red quinoa 7.8 g of aqueous extract (CFKW) were obtained. It should be noted that before carrying out subsequent biological exper...

Embodiment 2

[0041] Embodiment 2: the ethanol extraction of red quinoa

[0042] Red quinoa was purchased from the local farmers association in Chishang Township, Taitung County. After pounding red quinoa, take 100 grams of pounded extract and soak in 500 grams of 95% ethanol for three days. Then, the mixture was filtered with a Buchner funnel and an aspirator to obtain a clear filtrate. In addition, the filtered residue was soaked in 500 g of 95% ethanol for three days, and the mixture was filtered with a Buchner funnel and an air pump to obtain a clear filtrate. Finally, after mixing the two obtained filtrates, first concentrate the filtrate under reduced pressure, then freeze the concentrated filtrate at -80°C for about one day, and then freeze-dry it in a vacuum bottle to obtain the final product ethanol extract CFKE (extraction The yield is about 3.2%, and 100 grams of red quinoa can obtain 3.2 grams of ethanol extract (CFKE). It should be noted that before carrying out subsequent b...

Embodiment 3

[0043] Example 3: Cytotoxicity Rational Test

[0044] In view of the fact that the existing whitening agents or skin melanin inhibitors can cause cytotoxicity, after obtaining the red quinoa extract, the inventors first carried out the cytotoxicity test of this compound, using 100, 250 and 500 μg / After the red quinoa extract of ml concentration acted on HaCaT cells for 24 hours, the viability was determined by MTT assay. The result is as figure 1 It was shown that the water-extracted CFKW and the ethanol-extracted CFKE of red quinoa are not toxic in cells, and are safer than ascorbic acid (AA), which is a common ingredient in the market.

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Abstract

The invention relates to a Chenopodiumformosanum Koidz (CFK) extract with anti-aging, whitening, anti-allergic and cell repair functions, which is to administer an effective dose of CFK extract to skin cells. The invention has mechanism functions of DPPH and ABTS +free radical removal ability, reducing power, chelation of iron ions and inhibition of lipid peroxide efficiency; inhibition of tyrosinase activity; removal of nitric oxide (NO) free radicals, and inhibition of lipoxygenase (LOX-1) activity; inhibition of hyaluronidase, increase in the hyaluronidase content of the skin, promotion ofwound repair, and reduction of the production of wrinkles; inhibition of the activity of matrix metalloproteinases (MMPs), and reduction of the degradation of collagen; and promotion of the ability of cell repair, enhancement of the anti-allergic ability and the like.

Description

technical field [0001] The present invention relates to the application of red quinoa extract, especially refers to the use of red quinoa (CFKE) as an additive for cosmetics, skin care products and other skin care products to achieve anti-aging, anti-oxidation, anti-inflammation, inhibition of melanin, anti-wrinkle , anti-allergic and cell repair mechanisms. Background technique [0002] Modern orientals have increasing demands for clear skin and also attach importance to health. Therefore, how to propose a healthy way to lighten spots is a development focus for the external medicine industry. For beauty and maintenance, traditional plants are mostly warming and tonic medicines for invigorating qi, promoting blood circulation, and adjusting physical fitness. There are also a few single and compound prescriptions that are directly used for skin whitening, acne removal, and anti-inflammatory purposes. However, the mechanism analysis of active ingredients in plant extracts and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61Q19/08A61Q19/02A61Q19/00A61P29/00A61P37/08
CPCA61K8/9789A61K2800/782A61P29/00A61P37/08A61Q19/00A61Q19/02A61Q19/08
Inventor 梁家华曾良鹏陈品儒张子贤刘澄
Owner CHIA NAN UNIV PHARMACY & SCI
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