Application of Quail Egg and Quail Egg Ovomucoid in Anti-allergy

A technology of ovomucoid and quail eggs, which is applied in the fields of application, allergic diseases, peptide/protein components, etc., can solve problems such as difficult to guarantee no recurrence, adverse effects on human body, etc.

Active Publication Date: 2020-04-03
CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no treatment method that can completely cure allergic diseases, and even drug treatment is difficult to guarantee no recurrence
Moreover, chemical drugs generally have strong side effects, which will have adverse effects on the human body.

Method used

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  • Application of Quail Egg and Quail Egg Ovomucoid in Anti-allergy
  • Application of Quail Egg and Quail Egg Ovomucoid in Anti-allergy
  • Application of Quail Egg and Quail Egg Ovomucoid in Anti-allergy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Antiallergic Effects of Quail Eggs in Passive Skin Anaphylaxis

[0037] 1. Experimental animals

[0038] The SPF-grade Balb / c mice used in the experiment were purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., and were raised in the SPF-grade animal laboratory of the School of Food Science and Nutritional Engineering, China Agricultural University. The temperature of the feeding environment was maintained at 22±1°C, the humidity was stable at 55±5%, the day and night airflow was alternated every 12 hours, and the air exchange was 15 times / h. During the experiment, the animals could drink water and eat by themselves. The daily diet of mice was commercialized SPF grade rat maintenance feed, which was purchased from Beijing Keao Xieli Feed Co., Ltd. (Beijing, China). The main nutrients of the feed (moisture, ash, crude protein, fat, crude fiber, calcium and phosphorus) Meet the requirements of Chinese Standard GB14924.3-2010, and no aflatoxin ...

Embodiment 2

[0050] Antiallergic effect of ovomucoid combined with other antiallergic drugs in quail eggs

[0051] 1. Experimental materials

[0052] Cell line: HMC-1 cells in GI1640 medium containing 10% fetal bovine serum and 1% third antibody at 37°C, 5% CO 2 (volume fraction) cultured in an incubator, the suspended HMC-1 cells grew rapidly, and were subcultured when the cells accounted for about 50% of the total culture solution or when the color of the culture solution turned from red to yellow. When subculture, transfer the cells and culture medium to a centrifuge tube and centrifuge at 1500g at room temperature for 5 minutes, discard the culture medium, then add fresh GI1640 complete culture medium, pipette carefully to resuspend the cells in separate bottles for passage. The subculture ratio is 1:4, and the size of the subculture is 25cm 2 Culture bottle 5mL complete medium, pass once a day.

[0053] 2. Test product group:

[0054] Divided into three groups: quail egg ovomucoid...

Embodiment 3

[0070] Antiallergic effects of quail eggs or quail egg mucinoids in meat products

[0071] 1. Experimental materials

[0072] Quail eggs or ovomucoid; sausage casings; soybean protein isolate, flour, edible starch, gum arabic, edible salt, essence and other auxiliary materials are all commercially available food-grade products.

[0073] 2. Subjects

[0074] Choose 80 students with allergic history in our school, 40 of them are boys, aged 18 to 28, divided into experimental group and control group, each with 20 boys and 20 girls. There were no significant differences between the two groups in terms of age, gender, and type.

[0075] 3. Preparation method

[0076] After 5kg of pork is washed with water, it is ground with a meat grinder, and the meat slurry is used as the standard. Then 2kg of quail eggs or ovomucoid, 200g of soybean protein isolate, 500g of edible starch, 200g of gum arabic, 30g of edible salt, 30g of essence and other auxiliary materials were stirred and mi...

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Abstract

The invention discloses application of quail eggs and quail egg ovomucoid in resisting allergy. Passive cutaneous anaphylaxis of a rat PCA (Passive Cutaneous Anaphylaxis) model is researched to find that the quail eggs and the active ingredient ovomucoid thereof have an antiallergic effect. An HMC-1 cell line is used for researching the influence of the active ingredient ovomucoid in the quail eggs and an allied chemical antiallergic medicine on mast cell degranulation, and shows that the active ingredient ovomucoid in the quail eggs and the chemical antiallergic medicine are combined to havea synergetic antiallergic effect. The quail eggs or the quail egg ovomucoid is applied in food, cosmetics, daily necessities and medicines with antiallergic effects so as to achieve more safety, lowerside effect and low possibility of recurrence.

Description

technical field [0001] The invention relates to an antiallergic substance, in particular to the application of quail eggs and quail egg ovomucoid in antiallergic. Background technique [0002] Food allergy is an abnormal reaction of the human body to non-toxic substances. It is a reaction caused by the immune system against some allergens. The incidence of food allergies is currently on the rise worldwide, with far-reaching implications for the world's health care systems. Food allergens include proteins or glycoproteins with a molecular weight of 5-100 kDa and receptors capable of cross-linking IgE. Although many potential allergens are denatured by enzymatic digestion in the acidic environment of the stomach, there are some allergens that are not affected by these conditions. Animals and humans can detect complete food allergens in serum after oral administration of certain foods. [0003] Studies have reported various types of food allergens. The Food and Agriculture ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/57A61K38/17A61P37/08A61K8/98A61K8/64A61Q19/00A23L15/00A23L33/17
CPCA23L15/00A23L33/17A23V2002/00A61K8/64A61K8/982A61K35/57A61K38/17A61K2800/75A61Q19/00A23V2200/30A23V2250/5428
Inventor 车会莲
Owner CHINA AGRI UNIV
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