Application of quail eggs and quail egg ovomucoid in resisting allergy

An ovomucoid and quail egg technology, which can be used in applications, allergic diseases, peptide/protein components, etc., can solve problems such as adverse effects on the human body and difficulty in ensuring no recurrence.

Active Publication Date: 2018-05-11
CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there is no treatment method that can completely cure allergic diseases, and even drug treatment is difficult to guarantee no recurrence
Moreover, chemical drugs generally have strong side effects, which will have adverse effects on the human body.

Method used

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  • Application of quail eggs and quail egg ovomucoid in resisting allergy
  • Application of quail eggs and quail egg ovomucoid in resisting allergy
  • Application of quail eggs and quail egg ovomucoid in resisting allergy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Passive skin allergic reaction to study the anti-allergic effect of quail eggs

[0037] 1. Experimental animals

[0038] The SPF Balb / c mice used in the experiment were purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd. and raised in the SPF Animal Laboratory of the School of Food Science and Nutrition Engineering, China Agricultural University. The temperature of the breeding environment is maintained at 22±1°C, the humidity is stable at 55±5%, the air flow alternates day and night every 12 hours, and the air exchange is 15 times / h. During the experiment, the animals can drink and eat by themselves. The daily feed for mice is a commercial SPF maintenance feed for rats and mice, purchased from Beijing Keyao Xieli Feed Co., Ltd. (Beijing, China). The main nutrients of the feed (moisture, ash, crude protein, fat, crude fiber, calcium and phosphorus) Meet the requirements of Chinese Standard GB14924.3-2010, and no aflatoxin (≤20μg / kg) is detected. ...

Embodiment 2

[0050] Study on the antiallergic effects of ovomucoid and other antiallergic drugs in quail eggs

[0051] 1. Experimental materials

[0052] Cell line: HMC-1 cells in GI1640 medium containing 10% fetal bovine serum and 1% tertiary antibody at 37℃, 5% CO 2 When cultured in a (volume fraction) incubator, suspended HMC-1 cells grow rapidly, and passage when the cells account for about 50% of the total culture solution or when the color of the culture solution changes from red to yellow. When passaging, transfer the cells and culture medium to a centrifuge tube at 1500g and centrifuge for 5 min at room temperature, discard the culture medium, add fresh GI1640 complete culture medium, and pipette carefully to resuspend the cells for passage. The passage ratio is 1:4, and the passage is 25cm 2 Culture flask 5mL complete medium, transfer once a day.

[0053] 2. Test product group:

[0054] Divided into three groups: quail egg mucin group (P), chemical anti-allergic drug group (loratadine (L...

Embodiment 3

[0070] Study on the anti-allergic effect of quail eggs or quail egg mucins in meat products

[0071] 1. Experimental materials

[0072] Quail eggs or egg mucin; casing; soy protein isolate, flour, edible starch, gum arabic, edible salt, flavor and other auxiliary materials are all commercially available food-grade products.

[0073] 2. Subject

[0074] We selected 80 students with a history of allergies in our school, 40 of whom were boys, aged between 18 and 28, and were divided into experimental group and control group, each with 20 boys and 20 girls. There was no significant difference between the two groups in terms of age, gender, and type.

[0075] 3. Preparation method

[0076] After washing 5 kg of pork with water, use a meat grinder to mince it, taking the meat slurry as the standard. Then mix 2kg of quail eggs or egg mucin, 200g of soy protein isolate, 500g of edible starch, 200g of gum arabic, 30g of edible salt, 30g of flavor and other auxiliary materials. Stir and mix the ...

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Abstract

The invention discloses application of quail eggs and quail egg ovomucoid in resisting allergy. Passive cutaneous anaphylaxis of a rat PCA (Passive Cutaneous Anaphylaxis) model is researched to find that the quail eggs and the active ingredient ovomucoid thereof have an antiallergic effect. An HMC-1 cell line is used for researching the influence of the active ingredient ovomucoid in the quail eggs and an allied chemical antiallergic medicine on mast cell degranulation, and shows that the active ingredient ovomucoid in the quail eggs and the chemical antiallergic medicine are combined to havea synergetic antiallergic effect. The quail eggs or the quail egg ovomucoid is applied in food, cosmetics, daily necessities and medicines with antiallergic effects so as to achieve more safety, lowerside effect and low possibility of recurrence.

Description

Technical field [0001] The invention relates to an anti-allergic substance, in particular to the application of quail eggs and quail egg mucins in anti-allergic. Background technique [0002] Food allergy is an abnormal response of the human body to non-toxic substances, which is caused by the immune system against some allergens. At present, the incidence of food allergy is gradually increasing worldwide, which has a profound impact on the world's health care system. Food allergens include proteins or glycoproteins with a molecular weight of 5-100 kDa and receptors that have the ability to cross-link IgE. Although many potential allergens are denatured by enzymatic digestion in the acidic environment of the stomach, some allergens are not affected by these conditions. After taking certain foods orally in animals and humans, complete food allergens can be detected in the serum. [0003] Research has reported many types of food allergens. The Food and Agriculture Organization (F...

Claims

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Application Information

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IPC IPC(8): A61K35/57A61K38/17A61P37/08A61K8/98A61K8/64A61Q19/00A23L15/00A23L33/17
CPCA23L15/00A23L33/17A23V2002/00A61K8/64A61K8/982A61K35/57A61K38/17A61K2800/75A61Q19/00A23V2200/30A23V2250/5428
Inventor 车会莲
Owner CHINA AGRI UNIV
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