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Compound pharmaceutical composition for motion sickness

A composition and motion sickness technology, applied in the field of pharmacy, can solve the problems of undiscovered patent applications or reports of pharmaceutical compositions, and achieve the effect of good taste and good drug compliance

Inactive Publication Date: 2015-12-30
天津市聚星康华医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] After searching patents and related literature, no patent application or report about the pharmaceutical composition was found

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041]The prescription amount of 1000 tablets of scopolamine and chlorpheniramine compound oral dissolving film for motion sickness among the present invention is as follows:

[0042] Element Dosage per 1000 tablets (g) Scopolamine 0.06 Chlorpheniramine 0.91 Hypromellose E-15 10 Maltodextrin 6 Mannitol 6 Sucralose 0.8 glycerin 3 mint flavor 0.6 Titanium dioxide 0.05 purified water 140

[0043] Preparation Process:

[0044] (1) Weigh the raw and auxiliary materials according to the prescription quantity;

[0045] (2) Moisten chlorpheniramine with glycerin, add scopolamine, hydroxypropyl methylcellulose E-15, mannitol, maltodextrin and sucralose, mix, add 140g of purified water and stir well; stand for 30min;

[0046] (3) After the swelling is complete, add mint essence and titanium dioxide, stir well and let stand for 20 minutes;

[0047] (4) The coating film is obtained by drying at 60°C for 40 minut...

Embodiment 2

[0049] The prescription amount of 1000 tablets of scopolamine and chlorpheniramine compound chewable tablets for motion sickness in the present invention is as follows:

[0050] Element Dosage per 1000 tablets (g) Scopolamine 0.06 Chlorpheniramine 0.91 Mannitol 80 pregelatinized starch 50 Maltodextrin 25 citric acid 15 Magnesium stearate 5 Sucralose 1.2 strawberry flavor 0.6

[0051] Preparation Process:

[0052] (1) Weigh the raw and auxiliary materials according to the prescription quantity;

[0053] (2) After mixing scopolamine, chlorpheniramine and pregelatinized starch in equal increments, mix them with other excipients evenly, and directly compress into tablets to obtain the product.

Embodiment 3

[0055] The prescription amount of 1000 tablets of scopolamine and dimenhydrinate compound oral dissolving film for motion sickness in the present invention is as follows:

[0056] Element Dosage per 1000 tablets (g) Scopolamine 0.06 dimenhydrinate 6 Polacrilin Potassium Resin (IRP88) 6 Methylcellulose 12 Hydroxypropyl Cellulose 4 pregelatinized starch 4 sucrose 3 strawberry flavor 1 aspartame 1.5 Carmine 0.02 purified water 180 polyethylene glycol 5

[0057] Preparation Process:

[0058] (1) Weigh the raw and auxiliary materials according to the prescription quantity;

[0059] (2) Dissolve dimenhydrinate in 80g of purified water, add polacrilin potassium resin (IRP88) and stir evenly; dry at 60°C to obtain flavor-masking drug powder, pass through an 80-mesh sieve for later use;

[0060] (3) Moisten scopolamine with polyethylene glycol, add dimenhydrinate powder, methyl cellulose and hydrox...

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PUM

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Abstract

The invention discloses a compound pharmaceutical composition for motion sickness. The compound pharmaceutical composition comprises scopolamine and antihistamine type drugs, wherein chlorpheniramine, dimenhydrinate and levocetirizine are selected as the antihistamine type drugs preferably. Dosage forms suitable for the adult, the old and children can be prepared from the compound pharmaceutical composition and auxiliary materials acceptable in pharmaceutical preparation.

Description

technical field [0001] The invention belongs to the field of pharmacy and relates to a compound pharmaceutical composition for motion sickness. Background technique [0002] Motion sickness, also known as motion sickness (motionsickness), is a general term for motion sickness, seasickness, airsickness, and diseases caused by swinging, bumping, rotating, and accelerated motion caused by various reasons. [0003] The pathogenesis of motion sickness is not yet fully understood, mainly related to affecting vestibular function. The utricle of the inner eardrum labyrinth of the vestibular organ and the sac macula of the sac can feel the linear motion of up and down and left and right, and the hair cells of the three semicircular canals can sense the rotational motion. When the macula or hair cells are stimulated by a certain amount of abnormal movement, the nerve impulses are transmitted from the vestibular nerve to the vestibular nucleus, and then to the cerebellum and hypothala...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/46A61K31/495A61K31/522A61K31/5415A61K45/00A61P1/08A61K31/4402A61K31/135
Inventor 李化淋
Owner 天津市聚星康华医药科技有限公司
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