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Methods and kits for diagnosing or assessing risk of cervical cancer

A cervical cancer, kit technology, applied in biochemical equipment and methods, microbial determination/inspection, etc.

Inactive Publication Date: 2018-05-04
CHUNG GUNG MEDICAL FOUNDATION LINKOU BRANCH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in addition to viral infection, there are host risk factors associated with cervical cancer development

Method used

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  • Methods and kits for diagnosing or assessing risk of cervical cancer
  • Methods and kits for diagnosing or assessing risk of cervical cancer
  • Methods and kits for diagnosing or assessing risk of cervical cancer

Examples

Experimental program
Comparison scheme
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example 1

[0043] Example 1: Genome-wide Association Study (GWAS)

[0044] Such as Figure 1A Histologically diagnosed with CIN2 as shown in + A genome-wide association study (GWAS) of 642,832 single nucleotide polymorphisms (SNPs) was performed on 507 cases (cohort D1) vs. 920 female controls (cohort C) of AffymetrixAxiom genome-wide human arrays as findings Group.

[0045] in such as Figure 1B Validation of 75 CIN2 identified from GWAS in the independent validation set shown in + Associated SNPs and 4 cervical cancer-associated SNPs from the literature. Cohort N [n=600] were HPV-negative / normal cytology women from a population-based cervical cytology and HPV co-testing study, while Cohort D2 [n=306] were women with CIN2 + women.

[0046] In the prediction group ( Figure 1C ), subjects with HPV positive / normal (cohort P, n=758) were followed and served as the predictive group. The predictive validity was analyzed by logistic regression and receiver operating characteristic (RO...

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Abstract

Kits for diagnosing or assessing the risk of developing cervical cancer in a subject, containing an agent, such as a primer, for detecting at least one single nucleotide polymorphism (SNP) are provided. Also provided are methods for diagnosing or assessing the risk of developing cervical cancer in a subject, comprising the detection of at least one SNP.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of priority to US Provisional Application No. 62 / 413,088, filed October 26, 2016, which is hereby incorporated by reference in its entirety. Background technique [0003] The subject matter discussed in the Background section should not be assumed to be prior art merely because it is mentioned in the Background section. Similarly, the problems and knowledge of their causes mentioned in the background section should not be assumed to have been previously recognized in the prior art. The subject matter in the background section merely represents different approaches, which can also be inventions in themselves. [0004] Human papillomavirus (HPV) testing is widely used for cervical cancer screening. Women with vaginal HPV infection and normal cervical cytology are more likely to develop cervical cancer and / or cervical intraepithelial neoplasia (CIN) than women without vaginal HIV infec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886
CPCC12Q1/6886C12Q2600/156C12Q2535/131C12Q2600/118
Inventor 赖琼慧赵安琪林巧韵
Owner CHUNG GUNG MEDICAL FOUNDATION LINKOU BRANCH