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Application of Babao pill in preparation of medicines for inhibiting malignant development of stomach cancer

A technology of Babao Dan and its uses, which is applied in the field of traditional Chinese medicine, and can solve the problems such as the unclear molecular mechanism of gastric cancer cell inhibition

Inactive Publication Date: 2018-05-29
XIAMEN TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition to liver and gallbladder diseases and urinary system diseases, good results have also been achieved in the treatment of malignant tumors, autoimmune diseases and other intractable diseases, but the inhibitory effect and molecular mechanism of Babaodan on gastric cancer cells are still unclear

Method used

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  • Application of Babao pill in preparation of medicines for inhibiting malignant development of stomach cancer
  • Application of Babao pill in preparation of medicines for inhibiting malignant development of stomach cancer
  • Application of Babao pill in preparation of medicines for inhibiting malignant development of stomach cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Example 1 Cell Test

[0025] 1 material

[0026] 1.1 Drugs and cell lines

[0027] Babaodan was purchased from Xiamen Traditional Chinese Medicine Factory Co., Ltd. Human gastric cancer cell lines AGS and MGC803 were purchased from Shanghai Institute of Cell Biology, Chinese Academy of Sciences and stored in liquid nitrogen at the Medical Experimental Center of Fujian University of Traditional Chinese Medicine.

[0028] 1.2 Reagents and consumables

[0029] RPMI 1640 medium, fetal bovine serum (FBS), double antibodies (penicillin, streptomycin), 0.25% trypsin (Trypsin), dimethyl sulfoxide (DMSO) (Gibco, USA); tetramethylazoblue (MTT) dry powder (Beijing Solaibao Technology Co., Ltd.); phosphate buffer saline (PBS) (Hyclone, USA).

[0030] 1.3 Instruments

[0031] Ultra-clean bench (Suzhou purification equipment company); carbon dioxide incubator, -80 ℃ refrigerator (Thermo, USA); inverted microscope system (Leica Instrument Co., Ltd., Germany); Automatic cell cou...

Embodiment 2

[0062] Embodiment 2 animal test

[0063] 1 material

[0064] 1.1 Drugs

[0065] Babaodan was purchased from Xiamen Traditional Chinese Medicine Factory Co., Ltd. The Babaodan powder was prepared into 2.5 mg / mL Babaodan solution with phosphate buffered saline (PBS), dissolved by ultrasonication, sterilized by high pressure, and stored at 4°C for later use.

[0066] 1.2 Experimental animals

[0067] Inbred strain 615 mice, male, weighing 20±2g.

[0068] 2 Methods and results

[0069] Take transplantable forestomach squamous cell carcinoma (FC) tissue 8 days after transplantation, and make 1×10 10 / L of cell suspension, inject 0.2mL of cell suspension subcutaneously in the right armpit of mice. The mice successfully vaccinated were randomly divided into control group and treatment group, with 5 mice in each group. Every group of animals began to give oral administration on the second day after inoculation, and the administration group was administered with the prepared Bab...

Embodiment 3

[0072] Embodiment 3 clinical case

[0073] Case 1: Chen, male, born in 1964, was diagnosed with gastric cancer in 2009, stage II (T2N1M0), underwent radical resection of gastric cancer (distal resection), and took Babaodan Capsules after the operation, 2 times a day Time, 2 capsules each time, adhere to continuous medication, B ultrasound, CT follow-up for 67 months, no recurrence or metastasis.

[0074] Case 2: Huang, female, born in 1969, was diagnosed with gastric cancer in 2012, stage IIIA (T2N2M0), underwent radical gastrectomy (total gastrectomy), and took Babaodan Capsules after surgery, twice a day , 2 capsules each time, adhere to continuous medication, CT follow-up every 3-6 months, follow-up until November 2017, no recurrence or metastasis occurred.

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PUM

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Abstract

The invention belongs to the field of application of traditional Chinese medicine, and particularly relates to application of a Babao pill in preparation of medicines for inhibiting malignant development of stomach cancer. The malignant development of the stomach cancer comprises the recurrence of the stomach cancer and the transfer and diffusion of stomach cancer cells. The Babao pill has good development and application prospect, and the novel application is disclosed for the first time. The Babao pill mainly is prepared from the following components of calculus bovis, snake gall, antelope horn, pearl powder, radix notoginseng and musk.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to the application of Babaodan in the preparation of medicines for inhibiting the malignant development of gastric cancer. Background technique [0002] Gastric cancer is one of the most common malignant tumors. Globally, approximately 1 million newly diagnosed patients and approximately 740,000 patients die each year. Most patients with gastric cancer are at an advanced stage when they are first diagnosed with distant metastasis or local invasion. In fact, most cancer patients die not from carcinoma in situ but from metastatic carcinoma. Metastasis is one of the typical features of malignancy and significantly increases cancer-related mortality. In the treatment of patients with advanced gastric cancer, radiotherapy and chemotherapy are still the first choice. Common chemotherapy drugs include oxaliplatin, 5-FU, semustine, etc. Although more and more new ...

Claims

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Application Information

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IPC IPC(8): A61K36/258A61P35/00A61P35/04A61K35/413A61K35/583A61K35/32A61K35/618A61K35/55
CPCA61K35/32A61K35/413A61K35/55A61K35/583A61K35/618A61K36/258A61K2300/00
Inventor 关斌南淑华詹志学赖志成彭军林久茂郑珊珊陈西翌许舒瑜阳丽华曾智发陈晓琳
Owner XIAMEN TRADITIONAL CHINESE MEDICINE
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