Planning method for irreversible electroporation electrode pin layout

An irreversible electrical and electrode needle technology, applied in the parts of surgical instruments, computer-aided planning/modeling, medical science, etc., can solve problems such as limiting the application of IRE ablation technology, and achieve the effect of saving adjustment time and wide application

Inactive Publication Date: 2018-06-05
NANKAI UNIV
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

Because the shape of the area to be ablated is irregular and diverse, technicians often need a long time to adjust the position of the plane electrode needle and the depth of the electrode

Method used

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  • Planning method for irreversible electroporation electrode pin layout
  • Planning method for irreversible electroporation electrode pin layout
  • Planning method for irreversible electroporation electrode pin layout

Examples

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Example Embodiment

[0025] The overall planning process of a planning method for the arrangement of irreversible electroporation electrode needles provided by the present invention is as follows figure 1 Shown.

[0026] Ablation of a specific area is a coverage problem in three-dimensional space. Since the electrode needles must meet the constraints of being parallel to each other, the problem can be broken down into three parts to solve the problem, namely, selecting the needle entry plane, determining the position of the electrode needle on the plane, and adjusting the electrode needle depth. Analytical solution is used to obtain the electric field distribution to obtain the covering element of a single ablation. The purpose of the present invention is to have the smallest number of electrode needles in the area that meets the needle entry conditions. For the obstacle area, we construct a penalty function to avoid the collision between the electrode needle and the obstacle, and then use the NM sim...

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Abstract

The invention provides a planning method for irreversible electroporation electrode pin layout, comprising: first, depicting the three-dimensional coverage problem of tissue under ablation into a plane coverage and depth adjustment problem; second, selecting an electrode pin penetrating direction according to actual condition and restraints for the electrode pin layout process, using NM (Nelder and Mead's) simplex and particle swarm hybrid algorithm to find a plane electrode pin position, and adjusting electrode pin depth in the penetrating direction; third, providing three-dimensional coverage for an area under ablation in a simulated environment by electrode pin discharging. The planning method has the advantages that full ablation can be provided for an area under ablation, obstacles affecting electrode pins during pin layout is avoided, and ablation planning time is shortened; the method herein is a novel method for computer-aided IRE (irreversible electroporation) pin layout, basis is provided for the subsequent development of computer-aided IRE pin layout planning methods, and the IRE ablation technique is more widely applicable.

Description

technical field [0001] The invention relates to a planning method for the arrangement of irreversible electroporation electrode needles, which is generally applied to the fields of biology and robotics. Background technique [0002] Irreversible electroporation (IRE) is a biological tissue ablation technique, which inserts multiple electrode needles into the area to be ablated or its surroundings, and releases high-voltage electric pulses between two electrode needles that meet the constraints, so that in the Permanent perforation is formed on the surface of the cell membrane, which breaks the physiological balance of the cell and eventually causes cell death. IRE technology can be applied to sterilization and food preservation pretreatment, etc. [0003] The difficulty of IRE ablation is the arrangement of electrode needles. The current research on IRE ablation technology is usually to find a general method for electrode needle arrangement. The finite element simulation me...

Claims

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Application Information

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IPC IPC(8): A61B34/10A61B18/14A61B18/00
CPCA61B34/10A61B2018/00577A61B2018/143A61B2034/104A61B2034/107
Inventor 于宁波高丽张海艳
Owner NANKAI UNIV
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