A stirring shaft suitable for hydrogenation reaction and its application
A technology of hydrogenation reaction and stirring shaft, which is applied in chemical/physical/physicochemical fixed reactors, mixers with rotating stirring devices, chemical instruments and methods, etc., can solve the problem of affecting the quality of doxycycline hydrochloride products, difficult Obtain the index requirements, low hydrogenation reaction yield and other problems, to achieve the effect of reducing the generation of related by-products, reducing the reaction time, and improving product quality
Active Publication Date: 2021-01-08
河南后羿制药有限公司
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Problems solved by technology
[0003] In the synthesis process of doxycycline hydrochloride, hydrogenation reaction is a step in the whole synthesis process, but the yield of hydrogenation reaction is low and there are many by-products, which directly affect the product quality of doxycycline hydrochloride. Among them, β-doxycycline , metacycline, 4-epidoxycycline, impurity F (2-acetyl-2-deamidooxytetracycline) and other impurity indicators are difficult to meet the requirements of the EU and other countries
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[0020] A stirring shaft suitable for hydrogenation reactions such as Figure 1-3 As shown, it includes the main shaft 1 which is hollow inside. The main shaft 1 is provided with a suction drum, a dispersing disc and 2 stirring parts. The suction drum includes a drum clamp 2-1 and is relatively arranged on the drum clamp 2-1. The upper cover plate 2-2 and the lower cover plate 2-3, the upper cover plate 2-2 and the lower cover plate 2-3 are all made of circular plates, and the drum clamp 2-1 is also provided with 3 edge The drum clamp 2-1 is an arc-shaped plate 2-4 evenly distributed in the circumferential direction, and each arc-shaped plate 2-4 is located between the upper cover plate 2-2 and the lower cover plate 2-3; The disk clamp 4-1 on the 1 and the disk clamp 4-1 are also connected with four dispersion leaves 4-2 which are hollow inside, and the upper and lower end surfaces of the four dispersion leaves 4-2 are respectively connected with annular Circle 4-3, the cross-...
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The invention discloses a stirring shaft suitable for hydrogenation reaction, which comprises a hollow main shaft inside, on which a suction drum, a dispersing disc and two stirring parts are arranged, and the suction drum includes drum clamps and oppositely arranged For the upper cover plate and the lower cover plate on the drum clamp, there are also several arc-shaped plates distributed along the circumferential direction of the drum clamp on the drum clamp. The arc-shaped plates are located between the upper cover plate and the lower cover plate, and the upper part of the main shaft There is a group of air inlet holes corresponding to the position on the drum clamp, and the first group of air outlet holes, the second group of air outlet holes and the third group of air outlet holes are respectively opened on the circumference of the lower part of the main shaft from top to bottom, and 2 stirring parts They are respectively located at the first group of air outlets and the third group of air outlets, and the agitator is provided with air holes corresponding to the air outlets, and the dispersing plate is located at the second group of air outlets, and the dispersing plate is provided with the second group of air outlets. The stomata correspond to the stomata. The invention improves the product quality of doxycycline hydrochloride and reduces the production cost.
Description
technical field [0001] The invention belongs to the technical field of chemical synthesis of raw material medicines, and in particular relates to a stirring shaft suitable for hydrogenation reaction and its application. Background technique [0002] Doxycycline hydrochloride is a broad-spectrum semi-synthetic tetracycline antibiotic. It is synthesized from oxytetracycline through a series of reactions such as chlorination-dehydration-hydrogenation-transformation-salt formation. It is mainly used to treat sensitive leather Upper respiratory tract infection, tonsillitis, biliary tract infection, lymphadenitis, cellulitis, etc. caused by blue-positive bacteria and gram-negative bacilli. , can also be used to prevent falciparum malaria and leptospira infection. Doxycycline hydrochloride has the advantages of strong water solubility, good absorption and wide distribution. Therefore, it has many clinical applications and good therapeutic effect. Clinical veterinary medicine is m...
Claims
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IPC IPC(8): B01F7/00B01F3/04B01J19/18B01J4/00
CPCB01J4/007B01J19/0053B01J19/18B01F23/23311B01F23/2331B01F23/23764B01F27/2123B01F27/2122B01F2101/2204
Inventor 李星万毅张娇丽
Owner 河南后羿制药有限公司