Simultaneous estimation of respiratory dynamics and patient effort via parameter optimization

A parametric, respiratory muscle technology, applied in the respiratory field, can solve problems such as interference with mechanical ventilation modes

Active Publication Date: 2021-07-20
KONINKLJIJKE PHILIPS NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, this is an invasive technique that interferes with the therapeutic mode of mechanical ventilation that provides the patient with life-sustaining breaths

Method used

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  • Simultaneous estimation of respiratory dynamics and patient effort via parameter optimization
  • Simultaneous estimation of respiratory dynamics and patient effort via parameter optimization
  • Simultaneous estimation of respiratory dynamics and patient effort via parameter optimization

Examples

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Embodiment Construction

[0021] In the methods disclosed herein, the respiratory muscle pressure P mus (t), respiratory system resistance R rs and respiratory compliance C rs or Elastic E rs =1 / C rs Simultaneously estimated on a breath-by-breath basis by the formula for evaluating lung motion:

[0022]

[0023] Among them, P aw (t) is the measured airway pressure, is the measured airway flow, V(t) is the volume of air breathed, that is and P 基线 is a constant. In performing this simultaneous estimation, the airway pressure P aw (t) and airway flow is sampled. Evaluating N samples requires N+2 unknowns (including N P mus The value of (t) and R rs and C rs value) to solve. This is an underdetermined problem because the number of data points (N) is less than the number of unknowns (N+2).

[0024] In addition to the fact that the problem is underdetermined, another challenge recognized in this paper is that the measured airway pressure P aw (t) and airway flow Can be noisy, especial...

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Abstract

The present invention relates to simultaneous estimation of respiratory dynamics and patient effort via parameter optimization. Respiratory variables are estimated on a breath-by-breath basis from airway pressure and flow data collected by airway pressure and flow sensors (20, 22). A breath detector (28) detects breath intervals. The breath-per-breath respiratory variable estimator (30) fits the airway pressure and flow data within the breath interval to a respiratory muscle pressure curve (40) parameterized by airway pressure, airway flow, and individual breaths. , 42) A formula for the associated lung motion to generate optimized parameter values ​​for the parameterized respiratory muscle pressure curve for said single breath. The respiratory muscle pressure is estimated as a function of time within the detected breathing interval as a parameterized respiratory muscle pressure curve of the single breath with the optimized parameter value and can be displayed, for example, on a display device ( 26 , 36 ) are displayed as trend lines or integrated ( 32 ) to generate the work of breathing (WoB) for use in adjusting the settings of the ventilator ( 10 ).

Description

technical field [0001] The following generally relates to the field of respiration, the field of respiration monitoring, and related fields such as the field of mechanical ventilation. Background technique [0002] Clinical assessment of the respiratory system can be performed on a quantitative basis by estimating certain respiratory values ​​such as respiratory muscle pressure, respiratory system resistance, and respiratory system compliance or elasticity. [0003] Usually expressed as P mus The respiratory muscle pressure of (t) is the (negative) pressure exerted by the patient during breathing. More specifically, during inspiration, the diaphragm works to expand the volume of the lungs, thus reducing the pressure for a given volume of air (as in the case of blocked airways) or drawing air into the lungs (as in the case of normal inspiration in the case of). Respiratory muscle pressure is generally a useful measure for respiratory monitoring because it is a measure of t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61B5/087A61B5/03A61B5/085A61B5/091G16H20/40
CPCA61B5/038A61B5/085A61B5/087A61B5/091A61B5/682A61B2505/03G16H50/50G16H40/63G16H50/20G16H20/40A61B5/0816A61B5/7242A61B5/7275
Inventor F·比卡里奥A·阿尔巴内塞王东N·卡拉莫列赫科斯N·W·什巴特
Owner KONINKLJIJKE PHILIPS NV
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