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Injectable composition for skin tissue regeneration or skin tissue volume increase comprising hollow porous microspheres

A technology of tissue regeneration and porous microspheres, which is applied in the direction of skin care preparations, prostheses, cosmetic preparations, etc., can solve the problems of cutting skin tissue, achieve the effect of maintaining the effect, expanding the effect of increasing the volume of skin tissue

Inactive Publication Date: 2018-06-08
PHARMARES PROD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The hollow porous microspheres contained in the composition of the present invention have a small particle size, which can solve the shortcomings of the existing porous materials that need to cut the skin tissue for transplantation due to the large particle size

Method used

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  • Injectable composition for skin tissue regeneration or skin tissue volume increase comprising hollow porous microspheres
  • Injectable composition for skin tissue regeneration or skin tissue volume increase comprising hollow porous microspheres
  • Injectable composition for skin tissue regeneration or skin tissue volume increase comprising hollow porous microspheres

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] [Example 1] Production of hollow porous microspheres 1

[0040] Hollow porous microspheres according to an example of the present invention were manufactured by the following method.

[0041] Step 1: Fabrication of a simple fluidic device

[0042] A 30-gauge injection needle bent at 90° was placed in a PVC tube, and a microfluidic device was fabricated by inserting a fine glass tube between the injection needle and the PVC tube. The fabricated microfluidic device uses epoxy adhesive to plug the tiny gaps.

[0043] Step 2: Preparation of PLLA solution containing alkanes

[0044] 0.1 g of PLLA (RESOMER LR 704S, Evonik Industries AG) as a hydrophobic biodegradable polymer, 10 g of dichloromethane (34355-0350, Junsei), and an alkane substance as a pore formation inducing substance, specifically octane (Octane, 412236, Sigma-aldrich) or undecane (Undecane, U407, Sigma-aldrich) or tridecane (T57401, Sigma-aldrich) or pentadecane (Pentadecane, 76510, Sigma-aldrich) respecti...

Embodiment 2

[0052] [Example 2] Production of hollow porous microspheres 2

[0053] Hollow porous microspheres according to an example of the present invention were manufactured by the following method.

[0054] Step 1: Fabrication of a simple fluidic device

[0055] A 30-gauge injection needle bent at 90° was placed in a PVC tube, and a microfluidic device was fabricated by inserting a fine glass tube between the injection needle and the PVC tube. The fabricated microfluidic device uses epoxy adhesive to plug the tiny gaps.

[0056] Step 2: Manufacture of PLLA solution containing vegetable oil

[0057] Mix 0.1 g of PLLA (RESOMER LR 704S, Evonik Industries AG) as a hydrophobic biodegradable polymer, 10 g of methylene chloride (34355-0350, Junsei), and 0.5 g each of cottonseed oil or soybean oil as a stomatal formation inducing substance , thus making a hydrophobic biodegradable polymer (PLLA) solution.

[0058] Step 3: Create a uniform PLLA emulsion

[0059] Use the PLLA solution obta...

Embodiment 3

[0064] [Example 3] Production of Injectable Compositions Containing Hollow Porous Microspheres

[0065] As an embodiment of the present invention, the above-mentioned hollow porous microspheres and water-soluble substances such as hyaluronic acid (hyaluronic acid) and carboxymethylcellulose (carboxymethylcellulose) used to improve the viscosity and stability of the composition comprising porous microspheres Polymers are mixed to make injectable compositions.

[0066] At this time, the content of each composition is shown in Table 1 and Table 2 below, and also shows the results of measurement of injection pressure of the composition for injection containing hollow porous microspheres according to the content of each composition.

[0067] [Table 1]

[0068]

[0069] [Table 2]

[0070]

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Abstract

The present invention relates to an injectable composition for skin tissue regeneration or skin tissue volume increase comprising hollow porous microspheres comprising a cavity in the center thereof and a barrier surrounding the cavity and comprising fine pores. The hollow porous microspheres comprised in the composition according to the present invention have a small particle size, thus can be administered by an injection into skin tissue, and allow moving skin tissue cells to effectively proliferate within the cavities. After a predetermined period elapses, the newly proliferated skin tissuecells maintain the volume thereof even after the hollow porous microspheres biodegrade inside skin; and thus, skin tissue regenerative effects can be safely maintained for a long time.

Description

technical field [0001] The invention relates to an injectable composition for improving skin tissue regeneration or increasing skin tissue volume in skin wrinkles and sunken parts. Background technique [0002] In medical devices for cosmetic surgery sold for the purpose of cosmetic surgery, fillers are used to inject skin tissue into wrinkles and depressions. [0003] Most of the fillers are injected into the skin tissue and increase the volume of the skin tissue through the volume of the substance itself to improve skin wrinkles or depressions. Currently, the most widely used fillers are hyaluronic acid and collagen, which are in the form of gels without a fixed shape. However, there is a problem that the effect of cosmetic surgery will not be maintained for a long time because it is absorbed into the skin tissue over time. [0004] In addition, as a medical device for cosmetic surgery, in order to have a wide range of use, it needs to be delivered by injection, but the p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/31A61K8/92A61K8/73A61K8/84A61K8/02A61L27/14A61Q19/08
CPCA61K8/31A61L27/14A61K8/73A61K8/84A61Q19/08A61K8/92A61K8/02
Inventor 金赫阿泳昌崔星旭文昇官朴元锡
Owner PHARMARES PROD
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