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Rapid Surgical Adhesive Sealant

A technology for surgery and sealant, which is applied in the fields of surgical adhesives, surgery, medical science, etc., and can solve the problems of limiting the development and application of chemical in-situ hydrogel sealants, difficult to change shape, and toxic.

Active Publication Date: 2021-08-17
江西博恩锐尔生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But on the other hand, chemical in-situ hydrogels also have their own shortcomings: first, the chemical reactions that occur during the gelation process may be accompanied by drastic changes in temperature, pH, etc. damage to the human body; secondly, some catalysts that are toxic to the human body are likely to be needed in the gelation process; in addition, the chemical reaction in the gelation process may also have some harmful by-products to the human body; finally, due to its final hydrogel has Very good mechanical properties, making it difficult to change shape after being gelled
These all limit the development and application of chemical in situ hydrogel sealants

Method used

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  • Rapid Surgical Adhesive Sealant

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 2

[0058] 0.29g of p-toluenesulfonyl chloride (TsCl); 0.2g of phenyl p-nitrochloroformate (PNC); 0.39g of cholesterol; 1g of PEG with a molecular weight of 1000 and 1g of gelatin with a molecular weight of 1000 were synthesized by the method of the above scheme 1 Prepare the modified gelatin polysaccharide ① of the second component of the quick surgical adhesive sealant component set, that is, the cholesterol-modified gelatin polysaccharide ① with PEG chains, and prepare it with phosphate buffered saline (PBS) with a pH value of 4. into the second component solution. And the first component was prepared from 2-arm SG-PEG dry powder with single-arm molecular weight (10000), wherein the mass ratio of each component was multi-arm PEG:modified gelatin polysaccharide:PBS=20:0.2:79.8. The result is the Rapid Surgical Adhesive Sealant Kit. Take a set of the above-mentioned rapid surgical adhesive sealant assembly kit, use the second component solution to fully dissolve the first compon...

Embodiment 3

[0060] With 0.29g p-toluenesulfonyl chloride (TsCl); 0.2g phenyl p-nitrochloroformate (PNC); 0.39g cholesterol; 6g PEG with a molecular weight of 6000 and 3.5g gelatin with a molecular weight of 3500 through the method of the above scheme 1 Synthesize the modified gelatin polysaccharide ① of the second component of the rapid surgical adhesive sealant component set, that is, the cholesterol-modified gelatin polysaccharide ① with PEG chains, and use phosphate buffered saline (PBS) with a pH value of 8 Dubbed the second component solution. And the first component was prepared from 2-arm SG-PEG dry powder with single-arm molecular weight (8000), wherein the mass ratio of each component was multi-arm PEG:modified gelatin polysaccharide:PBS=15:2:83. The result is the Rapid Surgical Adhesive Sealant Kit. Take a set of the above-mentioned rapid surgical adhesive sealant assembly kit, use the second component solution to fully dissolve the first component solid powder and drop the mix...

Embodiment 4

[0062] 0.29g of p-toluenesulfonyl chloride (TsCl); 0.2g of phenyl p-nitrochloroformate (PNC); 0.39g of cholesterol; 3g of PEG with a molecular weight of 3000 and 2g of gelatin with a molecular weight of 2000 were synthesized by the method of the above scheme 1 Prepare the modified gelatin polysaccharide ① of the second component of the quick surgical adhesive sealant component set, that is, cholesterol-modified gelatin polysaccharide ① with PEG chains, and prepare it with phosphate buffered saline (PBS) with a pH value of 6. into the second component solution. And the first component was prepared from 2-arm SG-PEG dry powder with single-arm molecular weight (8000), wherein the mass ratio of each component was multi-arm PEG:modified gelatin polysaccharide:PBS=15:0.5:84.5. The result is the Rapid Surgical Adhesive Sealant Kit. Take a set of the above-mentioned rapid surgical adhesive sealant assembly kit, use the second component solution to fully dissolve the first component s...

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Abstract

Rapid Surgical Adhesive Sealant is a two-component in-situ hydrogel sealant designed to prevent leakage and infection at the surgical site after surgery. It comprises: multi-arm polyethylene glycol (multi-arm PEG-SG) powder with bisglutarate-hydroxysuccinimide ester modification (first component) in a first container (closed tray); A solution of modified gelatin (second component) in a second container (sealed plastic tubing or syringe); and a medical applicator stick (medical cotton swab or expanded polyethylene). When using, first open the second container, squeeze / inject the second component solution into the tray of the first container, and stir quickly with the end of the smear stick to completely dissolve the powder of the first component, and then glue it together by the tip of the smear stick. The sealant is applied to the surgical site and waits a few moments for a firm hydrogel sealant to form.

Description

technical field [0001] The invention relates to a medical adhesive, in particular to a polyethylene glycol (PEG) hydrogel medical adhesive. Background technique [0002] Compared with traditional surgical suture closure systems (such as: suture thread, hemostatic gauze, hemostatic sponge, polysaccharide hemostatic powder, etc.), in situ hydrogel sealant gradually stands out due to its many advantages, and has attracted more and more attention. [0003] First, the in situ hydrogel sealing adhesive exists in the form of a liquid precursor with no fixed shape before forming a gel, and acts directly on the site of action by simple injection or coating. The delivery method is simple, fast and easy to operate, and its unique characteristics of the amorphous liquid precursor also endow it with the ability to better contact the action site, making it more firmly adhered to the action site. Therefore, in-situ hydrogel adhesives are not limited by the irregular shape of the material'...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/10A61L24/00A61L24/04A61L24/08
CPCA61L24/0015A61L24/0031A61L24/046A61L24/08A61L24/104C08L71/02C08L15/00C08L89/00
Inventor 甘少磊
Owner 江西博恩锐尔生物科技有限公司