A microfluidic chip that realizes the synchronous movement and fusion of droplet pairs/bubble pairs

Abstract

The invention discloses a micro-fluidic chip achieving synchronous motion and fusion of fluid drop pairs / bubble pairs. A discrete phase inlet is formed in the middle of a continuous phase inlet enclosure; a dilution inlet is formed in an intersectional channel after a channel of the discrete phase inlet is connected with a channel of a continuous phase inlet; an intersection of the channel of thediscrete phase inlet and the channel of the continuous phase inlet is an intersection a; a continuous phase squeezes a discrete phase into discrete fluid drops / bubbles; the generated fluid drops / bubbles flow to a dilution intersection b under the guidance of a microchannel; a connecting part of the intersectional channel and a T-shaped channel is a split intersection c; when the fluid drops / bubbles flow through the split intersection c, each fluid drop / bubble is split into two equivalent fluid drops / bubbles; the fluid drop pairs / bubble pairs synchronously reach a fusion intersection d due to the T-shaped channel; and finally, all fluid flows out of an outlet and is collected for treatment. The fluid drop pairs synchronously flow to the intersection and meet by the action of a symmetrical structure and symmetrical flow, and the research requirements of fusion characteristics of the fluid drop pair are met.

Description

technical field [0001] The invention relates to a novel microfluidic chip, which utilizes a channel structure to guide liquid droplets / bubbles to realize synchronous movement and encounter fusion of droplet / bubble pairs. Background technique [0002] Micro-droplet technology is one of the important branches of microfluidic technology, which has developed rapidly in recent years. The micro-droplet system has outstanding advantages such as small size, large specific surface area, fast speed, high flux, uniform size, and closed system, and has been widely used in physics, chemistry, biology, and multidisciplinary fields. [0003] Droplet fusion is a very important droplet control technology. The droplet is used as the transport body to realize on-demand loading of reagents. It can be widely used in reagent mixing, particle synthesis, composite material preparation, DNA and blood analysis, food testing and other fields. . Generally, droplet fusion methods are divided into acti...

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Problems solved by technology

Usually a pair of droplets to be fused is generated separately by two generating structures. In this way, the droplet generation frequency is difficult to be controlled to ensure the stable encounter of the droplet pairs; the columnar array structure can reduce the arrival time difference of the droplet pairs, But it can only ensure that the time difference is in a small range, and the columnar structure involves many geometric parameters, such as the size of a single column and the mutual spacing, etc. Designing a droplet synchronization structure with better performance requires optimization of these structural parameters , including extensive experiments and numerical simulations

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