A kind of compound and its preparation method and antibacterial application

A technology for compounds and bacteriostatic agents, applied in the field of compounds and their preparation, can solve problems such as the decline of field effects, and achieve the effect of less raw materials

Active Publication Date: 2020-04-03
ZHONGKAI UNIV OF AGRI & ENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As a broad-spectrum fungicide, carbendazim has been found to have a certain inhibitory effect on peanut black rot fungi in laboratory studies, but the field effect has decreased significantly, which may also be related to the long-term application of such drugs in the field to produce resistance

Method used

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  • A kind of compound and its preparation method and antibacterial application
  • A kind of compound and its preparation method and antibacterial application
  • A kind of compound and its preparation method and antibacterial application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The preparation of embodiment 1 formula (I) compound

[0037]

[0038] Add 10 mmol of naphthaleneacetic acid (II), 10 mmol of N,N'-dicyclohexylcarbodiimide (DCC), a catalytic amount of 4-dimethylaminopyridine (DMAP) and 12 mmol of bromoethanol (III) into 30 mL of dichloromethane , stirred at room temperature for 2h. After completion of the reaction, add a large amount of water to extract, concentrate, and column chromatography to obtain a colorless intermediate compound (IV).

[0039]

[0040] Add 5mmol of carbendazim (V) to 20mL of dimethylformamide, stir at room temperature, add 7.5mmol of cesium carbonate, stir for 30min, cool down to 0°C, and dropwise add 6mmol of intermediate compound (IV) in N , N-dimethylformamide (DMF) solution 30mL, slowly warming up to room temperature, stirring for 36h. After the reaction was completed, the pH value was adjusted to neutral with 3 mol / L HCl solution, extracted with ethyl acetate, and column chromatographed to obtain th...

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Abstract

The invention relates to a compound as well as a preparation method and an application thereof, in particular to a preparation method of a novel medicament for inhibiting pestalotiopsis, peronophythora litchii and cylindrocladium parasiticum. Naphthylacetic acid technical, bromoethanol technical and carbendazim technical as synthesis raw materials are subjected to a reaction, and naphthylacetic acid-carbendazim conjugate is obtained and is the final product. The invention also discloses nuclear magnetic resonance structural data, hydrogen spectra and carbon spectra of the novel compound. The compound has good bacteriostatic effects on pestalotiopsis, peronophythora litchii and cylindrocladium parasiticum.

Description

technical field [0001] The invention belongs to the field of pesticides, and in particular relates to a compound and its preparation method and application. Background technique [0002] Studies have shown that due to the broad-spectrum of carbendazim, it has a certain inhibitory effect on the spp., Pyrosophthora lychee, and peanut black rot. Pestalotiopsis is a widely distributed plant pathogenic fungus, which is very harmful and has a high incidence rate. It can parasitize about more than 50 families of plants. After the plants are damaged, they will show symptoms such as leaf spots, rot, and ulcers. Affect product yield and quality. The pathogen exists in parasitic, saprophytic and endophytic species. The host plants of endophytic Discosporum are very extensive, including Pinaceae, Sequoiaceae, Orchidaceae, Palmaceae, Theaceae, etc. Studies have shown that carbendazim performed well against loquat gray spot caused by Trichosporum spp. in the indoor toxicity test, but t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D235/32A01N43/52A01P3/00
CPCA01N43/52C07D235/32
Inventor 杨静美叶滔刘光华郑奕雄雷泽湘王为华蒋锋
Owner ZHONGKAI UNIV OF AGRI & ENG
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