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Patch for bronchial asthma

A bronchial asthma and patch technology, applied in the field of drug extraction, can solve the problems of high cost, many types of raw materials, and unclear pharmacological effects

Inactive Publication Date: 2018-07-31
XIANGYU PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the patented technology "CN2013103914698, a kind of Xiangma Hanchuan patch and its preparation process" and "CN2015101716371, an application of Xiangma Hanchuan patch and its detection method" are improvements to the existing technology, mainly by adding a variety of The effect of raw material medicine is better than that of known medicines, but there are many kinds of raw materials, unclear pharmacological effects and high cost; the patented technology "CN2017109499108" improves the existing process of Xiangma Hanchuan paste, avoiding the distillation time Too long lead to the loss of efficacy caused by the destruction of picroside, total flavonoids and total phenolic acid content; on the basis of this patented technology, the applicant continued to improve the patch

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Patches for bronchial asthma, which include cloves, asarum, ginger, ginkgo biloba, perilla leaves, ephedra, mustard seeds, low ground tea;

[0022] Specifically, it is prepared according to the following process:

[0023] Step 1) Weigh 33g cloves, 100g asarum, 200g ginger, 100g ginkgo leaves, 60g perilla leaves, 200g ephedra, 200g mustard seeds, and 333g short tea;

[0024] Step 2) Mix cloves and asarum, crush them, pass through a 100-mesh sieve, slice ginger, mix the above raw materials, then add 6 times the weight of water, and use a high-speed shear for 30 minutes to obtain the soaking liquid. The shearing speed is 2000rpm , then distilled for 2 hours, the volatile oil was placed separately, and the extract A and medicinal residues were set aside;

[0025] Step 3) Mix ginkgo leaves and perilla leaves, crush them, pass through a 200-mesh sieve, place them in a reaction kettle, add 5 times the weight of 85% ethanol for extraction three times, each time for 6 hours, an...

Embodiment 2

[0037] Toxicity test: the patch prepared in Example 1 was pasted on the back of the depilated rabbit (the back of the projection of the lungs), each time for 4 hours, once a day for 2 consecutive weeks. Observation of its blood picture, lung, liver and kidney function showed no toxic effects; no toxic damage was found in the heart, liver, spleen, lung, kidney and other organs by pathological section. Therefore, it is suggested that the clinically recommended dosage is safe to use.

Embodiment 3

[0039] Animal experiment

[0040] As experimental animals, 120 male wistar rats of SPF grade were selected from the experimental animal center of our company. They were 6 weeks old and weighed (175±20) g. They were normal group, asthma model group, Example 1 group, Comparative Example 1 group, Comparative Example 2 group, and Comparative Example 3 group, with 20 rats in each group.

[0041]Establishment of chronic asthma rat model Except for the normal group, rats in other groups were prepared by referring to the Palmans method to prepare rat models of chronic asthmatic airway inflammation sensitized by ovalbumin (OVA). From the first OVA injection on day 1 to day 14 was the sensitization phase, and from day 15 to day 56 was the continuous challenge phase (6 weeks). Sensitization stage: On the first day, rats were injected intraperitoneally with 1 mL of a mixed solution of OVA and aluminum hydroxide (containing OVA10 mg and aluminum hydroxide 100 mg); on the eighth day, rats ...

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PUM

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Abstract

The invention belongs to the technical field of drug extraction and discloses a patch for bronchial asthma. The patch is prepared from clove flower, herba asari, fresh ginger, ginkgo leaf, perilla leaf, herba ephedrae, semen sinapis and Japanese ardisia herb. The patch disclosed by the invention has the beneficial effects that on the basis of the existing patch formula, by addition of alcohol extracts of the ginkgo leaf and the perilla leaf, the pharmaceutical effect is improved; the patch is superior to the known products and processes in the prior art, so that the application prospect is better.

Description

technical field [0001] The invention belongs to the technical field of drug extraction, and in particular relates to a patch for bronchial asthma. Background technique [0002] Bronchial asthma is a chronic airway inflammation involving a variety of cells and cell components. This kind of inflammation is often accompanied by increased airway reactivity, leading to recurrent symptoms such as wheezing, shortness of breath, chest tightness, and / or coughing. Occurring at night and / or in the early morning, these symptoms are often accompanied by widespread and variable airflow obstruction that can be reversed spontaneously or with treatment. Asthma manifests as paroxysmal cough, chest tightness and dyspnea. Some patients cough up sputum, mostly when the attack tends to be relieved. If there is no co-infection, the sputum is often white and sticky, with a tough texture, and sometimes it is rice grain or mucus columnar. The severity and duration of the attack vary greatly from pe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61K9/70A61P11/06
CPCA61K9/7023A61K36/16A61K36/17A61K36/185A61K36/268A61K36/31A61K36/535A61K36/61A61K36/9068A61K47/46A61K2236/31A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 林凡友王世礼郭增光罗晓倩
Owner XIANGYU PHARMA
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