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Glucose-sensitive type full interpenetrating network hydrogel and preparation method thereof

A glucose-sensitive, interpenetrating network technology, applied in the field of glucose-sensitive hydrogel and its preparation, can solve the problems of reducing PBA pKa, low pKa, low reproducibility, etc., and achieves improved response intensity and response rate, and mild reaction conditions. , the preparation method is simple

Inactive Publication Date: 2018-08-03
NORTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the pKa (8.6) of PBA is higher than the physiological pH. At pH 7.4, most of PBA is in an unionized state, and the binding force with glucose is very weak, and the response is very low.
At present, this problem is mainly solved by (1) synthesizing PBA derivatives with lower pKa, but the synthesis process is often complicated and expensive, and the yield is low
(2) Amino groups are introduced into the PBA polymer chain, and the adjacent amino groups will coordinate with the boron atom, reducing the pKa of PBA, but the amino groups on the side groups cannot be completely exposed, and the reproducibility is not high

Method used

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  • Glucose-sensitive type full interpenetrating network hydrogel and preparation method thereof
  • Glucose-sensitive type full interpenetrating network hydrogel and preparation method thereof
  • Glucose-sensitive type full interpenetrating network hydrogel and preparation method thereof

Examples

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preparation example Construction

[0037] The invention relates to a hydrogel sensitive to glucose under physiological conditions, and a method for preparing a temperature-sensitive hydrogel with mild reaction conditions and simple synthesis route. Glucose-sensitive fully interpenetrating network hydrogels based on PBA were synthesized through the interpenetration of networks formed by acrylamidophenylboronic acid (AAPBA)-based polymers and chitosan (CS). AAPBA, amides and the third monomer undergo free radical polymerization in the CS solution containing the first cross-linking agent, accelerator and initiator, and at the same time CS is cross-linked under the action of the second cross-linking agent. Glucose concentration-responsive hydrogels.

[0038]Among them, amides can be acrylamide (AM) or methacrylamide (MAm); the third monomer can be dimethylacrylamide (DMAA), dimethyl ethyl methacrylate (DMAEMA) or N-isopropyl base acrylamide (NIPAM); the first crosslinking agent is a diene crosslinking agent, such ...

Embodiment 1

[0052] The meaning of the data in brackets in Example 1 is marked in detail, and the meanings in brackets of each substance in other examples are the same as those in Example 1.

[0053] Example 1: Preparation of P(AAPBA-DMAA-AM) / CS-GA fully interpenetrating network hydrogel

[0054] (1) Dissolve 0.2 g of CS with a molecular weight of 300,000 in 10 ml of water to prepare a 2% CS solution.

[0055] (2) Pipette 1ml of CS solution, accurately weigh AAPBA: 0.096g (mole percent: 6%), AM: 0.156g (mole percent: 26%) and DMAA: 0.6ml (mole percent: 68%), crosslinking agent MBA : 4.14mg (0.5% of the mass sum of the three monomers) was placed in the solution, pipetted with a pipette and TEMED: 10ul, magnetically stirred for 10min until the solution was uniform, and at the same time, 0.5ml of freshly prepared APS solution (40mg / ml ) (2.4% of the mass sum of the three monomers), 10ul of GA solution, continued to stir for 20min, took out the magnet, and left it at room temperature for 24h ...

Embodiment 2

[0059] Example 2: Preparation of P(AAPBA-DMAA) / CS-GA fully interpenetrating network hydrogel

[0060] (1) Dissolve 0.2 g of CS with a molecular weight of 300,000 in 10 ml of water to prepare a 2% CS solution.

[0061] (2) Pipette 1ml of CS solution, accurately weigh AAPBA: 0.096g (5%) and DMAA: 1.0ml (95%), cross-linking agent MBA: 0.0106mg (1%) in the solution, pipette Take TEMED: 10ul, magnetically stir for 10min until the solution is uniform, add freshly prepared APS solution 0.2ml (40mg / ml) (0.75%), GA solution 10ul, continue stirring for 20min, take out the magnet, and stand at room temperature for cross-linking reaction .

[0062] (3) The prepared hydrogel was divided into small pieces, placed in distilled water to remove monomers, and the water was changed every 6 hours. After 48 hours, the samples were freeze-dried for subsequent related performance tests.

[0063] (4) Put a small piece of dry sample in PBS buffer solution (pH=7.3) to achieve equilibrium, and then pl...

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Abstract

The invention discloses glucose-sensitive type full interpenetrating network hydrogel and a preparation method thereof. The hydrogel comprises two interpenetrating networks including an AAPBA (acrylamidophenylboronic acid) polymer network and a CS (chitosan) crosslinked network. The hydrogel can reduce pKa of PBA, has good response strength and response rate for glucose under the physiological pHand has shortened swelling time and increased swelling degree as compared with gel without CS crosslinked networks, and the IPN structure improves the mechanical strength of the hydrogel. The preparation method of the hydrogel is simple, mild in reaction condition and suitable for industrial production.

Description

【Technical field】 [0001] The invention belongs to the field of medical polymer materials, and in particular relates to a glucose-sensitive hydrogel and a preparation method thereof. 【Background technique】 [0002] Diabetes is a common chronic metabolic disorder, which requires accurate monitoring of blood sugar levels to adjust insulin dosage to control blood sugar levels in patients. Only continuous measurement of blood sugar can effectively control the amount of insulin and avoid the occurrence of hypoglycemia. Continuous real-time blood glucose monitors and self-regulating insulin release systems are powerful tools for controlling blood sugar fluctuations. Glucose-responsive hydrogel plays a central role in the research of these two technologies. It can monitor the glucose concentration of the system and respond automatically, release the loaded insulin, and realize intelligent regulation of blood glucose concentration in diabetic patients. [0003] Glucose-responsive h...

Claims

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Application Information

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IPC IPC(8): C08F251/00C08F230/06C08F220/56C08F220/54C08F222/38C08J3/24C08J3/075A61K38/28A61K47/32A61K47/36A61P3/10C08L5/08
CPCA61K38/28A61K47/32A61K47/36A61P3/10C08F251/00C08J3/075C08J3/243C08J2305/08C08F230/06C08F220/56C08F220/54C08F222/38
Inventor 郝红王君王婷董广利魏培贺
Owner NORTHWEST UNIV
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