A kind of rutin-loaded polymer micelles and preparation method thereof

A technology of polymer glue and polymer, which is applied in the field of medicine, can solve the problems of increasing the solubility of rutin, achieve the effect of improving the release rate and overcoming the difficulty of being soluble in water

Inactive Publication Date: 2021-01-12
GUANGXI UNIV FOR NATITIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The survey found that there is no relevant report on the use of amphiphilic copolymers as carriers to increase the solubility of rutin

Method used

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  • A kind of rutin-loaded polymer micelles and preparation method thereof
  • A kind of rutin-loaded polymer micelles and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Weigh 100 mg of rutin and 500 mg of maleic rosin polyethylene glycol (2000) ester, dissolve them in 10 mL of hot absolute ethanol, and add them dropwise to rapidly stirred 30 mL of distilled water. Stir in a water bath at 50°C, evaporate the ethanol, filter the resulting solution through a 0.22 μm filter membrane, collect the filtrate, and obtain a rutin-encapsulated polymer micelle solution.

Embodiment 2

[0026] Weigh 90 mg of rutin and 510 mg of maleic rosin polyethylene glycol (1000) ester, dissolve them in 10 mL of hot absolute ethanol, and add them dropwise to rapidly stirred 30 mL of distilled water. Stir in a water bath at 50°C, evaporate the ethanol, filter the resulting solution through a 0.22 μm filter membrane, collect the filtrate, and obtain a rutin-encapsulated polymer micelle solution.

Embodiment 3

[0028] Weigh 80 mg of rutin and 520 mg of maleic rosin polyethylene glycol (200) ester and dissolve them in 10 mL of hot absolute ethanol, and add them dropwise to rapidly stirred 30 mL of distilled water. Stir in a water bath at 50°C, evaporate the ethanol, filter the resulting solution through a 0.22 μm filter membrane, collect the filtrate, and obtain a rutin-encapsulated polymer micelle solution.

[0029] Adopt high-performance liquid chromatography (HPLC) method to measure the drug encapsulation efficiency and the drug loading capacity of the polymer micelle solution of encapsulating rutin prepared by above-mentioned different prescriptions, the laser particle size analyzer measures the particle size, the results are shown in Table 1 shown. The stability of the solution was investigated, and the stability time of the three solutions at room temperature was greater than 24h.

[0030] Table 1 The quality evaluation of different prescription rutin polymer micelles solution ...

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Abstract

Provided is a rutin-coated polymer micelle. The polymer micelle consists of rutin and a rutin-coated carrier in a mass ratio of 1:3-100. A method for preparing a rutin-coated polymer micelle solutionincludes the steps that (1), the rutin and the carrier are dissolved in an organic solvent, and then the organic solvent in which the carrier and the rutin are dissolved is added dropwise to the distilled water under high-speed stirring; (2), the organic solvent in a product (1) is volatilized and then filtered through a filter film, and filtrate is collected to obtain the product. According to the polymer micelle and the method, the solubility and bioavailability of the poorly soluble active ingredient rutin of traditional Chinese medicines can be improved.

Description

technical field [0001] The invention relates to a polymer micelle carrying rutin and a preparation method thereof, belonging to the field of medicine. Background technique [0002] Rutin, also known as rutin and purple quercetin, is a flavonoid compound with a wide range of sources. Many plants in nature, such as Sophora japonica, tartary buckwheat, and dandelion, are rich in rutin, which has antioxidant, antibacterial, Anti-inflammatory, anti-convulsant, neuroprotective and cardiovascular and cerebrovascular protective effects and other biological activities. Due to its wide range of biological activities, high safety and rich sources, rutin is often used in medical care. At present, only tablets of rutin are on the market in China. Due to the poor water solubility of rutin, low dissolution rate in the gastrointestinal tract, and extremely low oral bioavailability, the efficacy and clinical application of rutin are limited. In order to improve its solubility in water and ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/107A61K31/7048A61K47/44
CPCA61K9/1075A61K31/7048A61K47/44
Inventor 许海棠周菊英赵彦芝雷福厚卢建芳
Owner GUANGXI UNIV FOR NATITIES
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