Constructing composite nanomedicine by coupling drug components with nanoparticles, preparation method and application

A nano-drug and inorganic nano-particle technology, which is applied in the direction of drug combinations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve problems such as difficulties
CN108404137BActive Publication Date: 2021-03-30郑州天兆医疗科技有限公司
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
郑州天兆医疗科技有限公司
Publication Date
2021-03-30

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Abstract

The invention discloses a composite nano-drug constructed by nanoparticles coupled with pharmaceutical ingredients as well as a preparation method and an application of the composite nano-drug, and belongs to the technical field of composite drugs. The method for preparing the nano-drug comprises the following operations: modifying amino on the surfaces of nanoparticles which contain hydroxy in the surfaces, and activating biological or small-molecular drugs containing hydroxy; and then conducting a conjugate coupling reaction on the nanoparticles and the drugs, so that a plurality of chemicalbonds are constructed, combining the plurality of chemical bonds so as to prepare the nano-drug. Based upon researches, it is indicated that an anti-cancer effect can be greatly improved on the basisof a synergistic effect between active ingredients of natural drugs (such as taxol, ginsenoside and other traditional Chinese medicines) and a nano-material, and meanwhile, key and breakthrough points can be also provided for researching and producing efficient anti-cancer nano-drugs which are low or free from toxic and side effects and have targeting and autonomous targeting performances.
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Description

technical field

[0001] The invention belongs to the technical field of novel composite medicines, in particular to the technical fields of antineoplastic medicines and Parkinson's syndrome medicines, and relates to the coupling of nanoparticles and active ingredients of traditional Chinese medicines into a type of composite nanomedicine and a preparation method. Background technique

[0002] In recent years, due to environmental changes, food safety and the gradual increase in the proportion of elderly population with high incidence of cancer and other factors, the number of patients and deaths of malignant tumors in the world and in my country has shown a trend of accelerated development. In 2010, the global malignant tumor The number of morbidity and death toll is 12.34 million and 7.7 million respectively. It is estimated that by 2050, these two figures will reach 23.83 million and 16 million. The morbidity and mortality in developing countries are significantly higher than...

Claims

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