Application of circ-0079591 in serum as marker for URSA diagnosis and pregnancy outcome assessment

A marker and outcome technology, applied in the field of biomedicine, can solve the problems of lack of a clear and unified standard for clinical intervention and treatment, endangering the reproductive health of women of childbearing age, and inability to effectively predict the outcome of pregnancy. It achieves high specificity, high diagnostic accuracy, Easy to detect effects

Active Publication Date: 2018-08-21
SHANDONG UNIV OF TRADITIONAL CHINESE MEDICINE +1
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

URSA seriously endangers the reproductive health of women of childbearing age, but there is still a lack of biological indicators with strong specificity, high sensitivity, and good stability. There is no clear and unified standard for clinical intervention and treatment, and it is impossible to effectively predict pregnancy outcomes.

Method used

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  • Application of circ-0079591 in serum as marker for URSA diagnosis and pregnancy outcome assessment
  • Application of circ-0079591 in serum as marker for URSA diagnosis and pregnancy outcome assessment
  • Application of circ-0079591 in serum as marker for URSA diagnosis and pregnancy outcome assessment

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Embodiment Construction

[0030] It should be noted that the following detailed description is exemplary and intended to provide further explanation of the present invention. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.

[0031] It should be noted that the terminology used here is only for describing specific embodiments, and is not intended to limit exemplary embodiments according to the present invention. As used herein, unless the context clearly dictates otherwise, the singular is intended to include the plural, and it should also be understood that when the terms "comprising" and / or "comprising" are used in this specification, they mean There are features, steps, operations and / or combinations thereof.

[0032] Explanation of terms:

[0033] circ_0079591: circular RNA0079591, the nucleic acid sequence of which is shown in SEQ ID NO:1.

[0034] As introduced...

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Abstract

The invention discloses application of circ-0079591 in serum as a marker for URSA diagnosis and pregnancy outcome assessment, and develops a corresponding detection kit by using the circ-0079591 as the marker for URSA diagnosis and pregnancy outcome assessment, wherein the kit has advantages of high detection sensitivity, high specificity and convenient detection, meets the detection needs of patients requiring URSA diagnosis, and has high diagnosis accuracy through clinical verification.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to the application of circ_0079591 in serum as a marker for the diagnosis of unexplained recurrent spontaneous abortion (URSA) and pregnancy outcome assessment. Background technique [0002] Spontaneous abortion occurs twice or more in a row, which is called recurrent spontaneous abortion (RSA). The incidence rate is about 1% to 5% of women of childbearing age. The etiology is complex, except for a few chromosomes, endocrine, anatomy, infection and other factors. In addition, about 80% of the cause is unknown, known as unexplained recurrent spontaneous abortion (unexplained recurrentspontaneous abortion, URSA). URSA seriously endangers the reproductive health of women of childbearing age, but currently there is a lack of biological indicators with strong specificity, high sensitivity, and good stability. There is no clear and unified standard for clinical intervention and trea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6883C12N15/113
CPCC12Q1/6883C12Q2600/136C12Q2600/158C12Q2600/178
Inventor 李霞王彬赵霖张华张云虹尹训强魏然张振朱肖肖郭强
Owner SHANDONG UNIV OF TRADITIONAL CHINESE MEDICINE
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