A kind of oral spray for assisting dental caries treatment and prevention of dental caries and preparation method thereof

An oral spray and dental caries technology, applied in the field of medicine, can solve the problems of antibacterial, anti-inflammatory, poor effect of promoting wound healing, less natural active substances, toxic and side effects of sodium fluoride, etc., achieve excellent antibacterial effect, assist dental caries treatment and Prevent dental caries and inhibit sugar metabolism

Active Publication Date: 2019-11-22
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The oral tooth protection spray provided by this invention can prevent gingivitis, reduce dental plaque, eliminate oral odor, prevent children's dental caries, etc., but the invention is less targeted for dental caries prevention and treatment, and its anti-caries effect is weak. Fewer active substances, antibacterial, anti-inflammatory, and poor wound healing effects; and sodium fluoride has toxic side effects

Method used

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  • A kind of oral spray for assisting dental caries treatment and prevention of dental caries and preparation method thereof
  • A kind of oral spray for assisting dental caries treatment and prevention of dental caries and preparation method thereof
  • A kind of oral spray for assisting dental caries treatment and prevention of dental caries and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] An oral spray for assisting dental caries treatment and prevention of dental caries, comprising the following percentages of raw materials:

[0046]

[0047] The sum of each component is 100%.

[0048] The preparation method of the above-mentioned oral spray for assisting dental caries treatment and prevention of dental caries comprises steps:

[0049](1) Weigh 2g of lactitol, 1g of erythritol, and 2g of EGCG and dissolve them in 500g of sterile water to form a solution, mix well to obtain solution A;

[0050] (2) Weigh 1g apigenin, 2g TT-farnesol, 3g propolis extract, 1g licochalcone A, 3g L-menthol and dissolve them in 50g edible alcohol with a volume concentration of 95%, and mix well to obtain solution B ;

[0051] (3) Mix solution A and solution B evenly, add sterile water to 1000g, filter and sterilize, and fill in a spray bottle.

Embodiment 2

[0053] An oral spray for assisting dental caries treatment and prevention of dental caries, comprising the following percentages of raw materials:

[0054]

[0055] The sum of each component is 100%.

[0056] The preparation method of the above-mentioned oral spray for assisting dental caries treatment and prevention of dental caries comprises steps:

[0057] (1) Weigh 1g of lactitol, 0.5g of erythritol, and 1g of EGCG and dissolve them in 500g of sterile water to form a solution, mix well to obtain solution A;

[0058] (2) Take by weighing 0.5g apigenin, 1g TT-farnesol, 2g propolis extract, 0.5g licochalcone A, 2g levomenthol and be dissolved in 20g of edible alcohol whose volume concentration is 95%, and mix evenly to obtain Solution B;

[0059] (3) Mix solution A and solution B evenly, add sterile water to 1000g, filter and sterilize, and fill in a spray bottle.

Embodiment 3

[0061] An oral spray for assisting dental caries treatment and prevention of dental caries, comprising the following percentages of raw materials:

[0062]

[0063]

[0064] The sum of each component is 100%.

[0065] The preparation method of the above-mentioned oral spray for assisting dental caries treatment and prevention of dental caries comprises steps:

[0066] (1) Weigh 3g of lactitol, 2g of erythritol, and 3g of EGCG and dissolve them in 500mL of sterile water to form a solution, mix well to obtain solution A;

[0067] (2) Weigh 2g apigenin, 3g TT-farnesol, 4g propolis extract, 2g licochalcone A, 4g levomenthol and dissolve them in 80g edible alcohol with a volume concentration of 95%, and mix to obtain solution B ;

[0068] (3) Mix solution A and solution B evenly, add sterile water to 1000g, filter and sterilize, and fill in a spray bottle.

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Abstract

The invention provides an oral spray for assisting decayed tooth treatment and preventing decayed teeth and a preparation method thereof. The oral spray provided by the invention comprises the following raw materials: apigenin, lactitol, farnesol, erythritol, epigallocatechin gallate, propolis extract, menthol, licochalcone A, ethanol, and sterile water. The oral spray provided by the invention has an obvious antibacterial effect, particularly has a good antibacterial effect on streptococcus mutans, which is the main pathogenic bacterium of decayed teeth, can inhibit the growth of the streptococcus mutans and the like, and has good removal ability on biofilms formed by the streptococcus mutans and the like, so that decayed tooth treatment can be effectively assisted and decayed teeth can be prevented; in addition, the oral spray is beneficial to regeneration of epithelial cells so as to heal ulcer wounds, and has obvious antibacterial, anti-inflammatory and ulcer healing promoting effects.

Description

technical field [0001] The invention relates to an oral spray for assisting caries treatment and caries prevention and a preparation method thereof, belonging to the technical field of medicine. [0002] technical background [0003] Dental caries, commonly known as tooth decay and tooth decay, is a bacterial disease that can cause pulpitis, periapical periodontitis, and even alveolar bone and jaw inflammation; if dental caries is not treated in time, the lesions will continue to develop, and caries cavities will form. Gradually develops until the crown is completely destroyed and disappears, eventually leading to tooth loss. Dental caries has a high incidence rate and is widely distributed. It is one of the main common diseases of the oral cavity. The World Health Organization has listed it as one of the three major diseases of human beings, along with tumors and cardiovascular diseases. [0004] Bacteria are a necessary condition for the occurrence of dental caries. The ma...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K35/644A61K9/12A61P1/02A61P31/02A61P31/04A61K31/045A61K31/047A61K31/12A61K31/352
CPCA61K9/006A61K31/045A61K31/047A61K31/12A61K31/352A61K35/644A61P1/02A61P31/02A61P31/04A61K2300/00
Inventor 冯强唐迪
Owner SHANDONG UNIV
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