A multi-scale coupling simulation method for complex microfluidic chips

Abstract

The invention discloses a multi-scale coupling simulation method for complex microfluidic chips, which comprises the following steps: firstly, the simulation based on the finite element method is performed on the action of each single physical field on the biological particles in the microfluidic chip; The multi-phase flow simulation of the biological particle model based on the lattice Boltzmann method is carried out based on the comprehensive effect of multi-physics fields on the biological particles; compared with the deformation and tracking problems at the two-phase interface that are difficult to deal with by traditional simulation methods, the present invention adopts mesoscopic The lattice Boltzmann simulation method can well reflect the deformation and trajectory tracking of cells; the mesoscopic lattice Boltzmann simulation method is used to solve the internal flow field of the microfluidic chip, which is not limited by the assumption of fluid continuity and can Reflect the essence and subtle changes of fluid flow.

Description

technical field [0001] The invention relates to the technical field of micro-total analysis systems, in particular to a multi-scale coupling simulation method for complex microfluidic chips. Background technique [0002] With the development of Micro Electro-Mechanical System (MEMS, Micro Electro-mechanical System), microfluidic chip technology has attracted widespread attention. The goal of science and technology is to integrate the basic functions of laboratories such as biology, chemistry, and medicine into centimeter-level chips, so microfluidic chips are also called Lab On a Chip. In a microfluidic chip, the laminar flow can be precisely controlled by fluid force or external field force, or thousands of cells can be manipulated. Due to the miniaturization of the microfluidic chip, it can realize portable, low consumption, integrated analysis, and can greatly shorten the analysis time. These advantages make the microfluidic chip technology an important means in particle...

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Problems solved by technology

[0003] The purpose of the present invention is to overcome the shortcomings and deficiencies of the prior art, and provide a multi-scale coupling simulation method for complex microfluidic chips, which is a finite element-lattice Boltzmann coupling simulation based on complex microfluidic chips The method is used to solve the problem of deformation and tracking at the two-phase interface and the difficulty of describing the fluid flow inside the chip when using the multi-phase module to simulate cell deformation and motion in the existing traditional single simulation method. low problem

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