Complex micro-fluidic chip-oriented multiscale coupling simulation method

Abstract

The invention discloses a complex micro-fluidic chip-oriented multiscale coupling simulation method. The method comprises the following steps of: firstly carrying out finite element method-based simulation on each single physical field action suffered by biological particles in a micro-fluidic chip; and carrying out lattice Boltzmann method-based biological particle model multi-phase flow simulation on a multi-physical field synthetic action suffered by the biological particles. Compared with the problem that the traditional simulation methods are difficult to process deformation and trackingproblem at two intersection interfaces, the method adopts a mesoscopic lattice Boltzmann simulation method, so that deformation and motion trajectory tracking of cells can be well reflected; and the mesoscopic lattice Boltzmann simulation method is used for solving flow fields in micro-fluidic chips without being limited by fluid continuity assumption, so that essential and subtle changes of fluidflowing can be reflected.

Description

technical field [0001] The invention relates to the technical field of micro-total analysis systems, in particular to a multi-scale coupling simulation method for complex microfluidic chips. Background technique [0002] With the development of Micro Electro-Mechanical System (MEMS, Micro Electro-mechanical System), microfluidic chip technology has attracted widespread attention. The goal of science and technology is to integrate the basic functions of laboratories such as biology, chemistry, and medicine into centimeter-level chips, so microfluidic chips are also called Lab On a Chip. In a microfluidic chip, the laminar flow can be precisely controlled by fluid force or external field force, or thousands of cells can be manipulated. Due to the miniaturization of the microfluidic chip, it can realize portable, low consumption, integrated analysis, and can greatly shorten the analysis time. These advantages make the microfluidic chip technology an important means in particle...

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Problems solved by technology

[0003] The purpose of the present invention is to overcome the shortcomings and deficiencies of the prior art, and provide a multi-scale coupling simulation method for complex microfluidic chips, which is a finite element-lattice Boltzmann coupling simulation based on complex microfluidic chips The method is used to solve the problem of deformation and tracking at the two-phase interface and the difficulty of describing the fluid flow inside the chip when using the multi-phase module to simulate cell deformation and motion in the existing traditional single simulation method. low problem

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