Complex micro-fluidic chip-oriented multiscale coupling simulation method

A technology of microfluidic chips and simulation methods, applied in the field of micro-full analysis systems, can solve problems such as difficult fluid flow, low parallel efficiency, large amount of characterization and calculation, etc., to reduce code writing, save computing resources, improve deformation and The effect of motion trajectory tracking

Active Publication Date: 2018-08-24
GUANGDONG UNIV OF TECH
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Problems solved by technology

[0003] The purpose of the present invention is to overcome the shortcomings and deficiencies of the prior art, and provide a multi-scale coupling simulation method for complex microfluidic chips, which is a finite element-lattice Boltzmann coupling simulation based on complex microfluidic chips The method is used to solve the problem of deformation and tracking at the two-phase interface and the difficulty of describing the fluid flow inside the chip when using the multi-phase module to simulate cell deformation and motion in the existing traditional single simulation method. low problem

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  • Complex micro-fluidic chip-oriented multiscale coupling simulation method
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  • Complex micro-fluidic chip-oriented multiscale coupling simulation method

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[0026] The present invention will be further described in detail below in conjunction with the embodiments and the accompanying drawings, but the embodiments of the present invention are not limited thereto.

[0027] Such as Figure 1~4 As shown, a multi-scale coupling simulation method for complex microfluidic chips includes the following steps:

[0028] Firstly, the simulation based on the finite element method is performed on the single physical field effects (such as electric field or magnetic field) on the biological particles in the microfluidic chip. The multiphase flow simulation of the biological particle model of the Zeman method, the comprehensive effect of multi-physics fields here is the comprehensive effect of physical fields such as electric field and magnetic field;

[0029] The simulation results of the macro-scale finite element method as the initial conditions of the mesoscopic-scale Lattice Boltzmann method include: need to match the time step of the macro...

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Abstract

The invention discloses a complex micro-fluidic chip-oriented multiscale coupling simulation method. The method comprises the following steps of: firstly carrying out finite element method-based simulation on each single physical field action suffered by biological particles in a micro-fluidic chip; and carrying out lattice Boltzmann method-based biological particle model multi-phase flow simulation on a multi-physical field synthetic action suffered by the biological particles. Compared with the problem that the traditional simulation methods are difficult to process deformation and trackingproblem at two intersection interfaces, the method adopts a mesoscopic lattice Boltzmann simulation method, so that deformation and motion trajectory tracking of cells can be well reflected; and the mesoscopic lattice Boltzmann simulation method is used for solving flow fields in micro-fluidic chips without being limited by fluid continuity assumption, so that essential and subtle changes of fluidflowing can be reflected.

Description

technical field [0001] The invention relates to the technical field of micro-total analysis systems, in particular to a multi-scale coupling simulation method for complex microfluidic chips. Background technique [0002] With the development of Micro Electro-Mechanical System (MEMS, Micro Electro-mechanical System), microfluidic chip technology has attracted widespread attention. The goal of science and technology is to integrate the basic functions of laboratories such as biology, chemistry, and medicine into centimeter-level chips, so microfluidic chips are also called Lab On a Chip. In a microfluidic chip, the laminar flow can be precisely controlled by fluid force or external field force, or thousands of cells can be manipulated. Due to the miniaturization of the microfluidic chip, it can realize portable, low consumption, integrated analysis, and can greatly shorten the analysis time. These advantages make the microfluidic chip technology an important means in particle...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06F17/50
CPCG06F30/23G06F30/367
Inventor 黄志刚彭浩宇陈英怀蔡文莱黄亚军
Owner GUANGDONG UNIV OF TECH
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