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A gel transdermal preparation for treating gouty arthritis and its preparation method

A technology of gouty arthritis, transdermal preparation, applied in the field of medicine

Active Publication Date: 2021-03-16
山东肽莱生物制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current first-line anti-inflammatory drugs are colchicine, non-steroidal anti-inflammatory drugs and glucocorticoids, all of which have many adverse reactions

Method used

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  • A gel transdermal preparation for treating gouty arthritis and its preparation method
  • A gel transdermal preparation for treating gouty arthritis and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1 Preparation of an external gel preparation for the treatment of gouty arthritis

[0023] Table 1 The composition of the external gel preparation for the treatment of gouty arthritis

[0024]

[0025] Prepare according to the prescription in Table 1, and the preparation method is as follows:

[0026] 1) Take the prescribed amount of quercetin, sennoside B, polyethylene glycol 1000 vitamin E succinate, cholesterol, soybean lecithin and absolute ethanol, mix them, and place them in a stirrer at 500 rpm at 30°C in the dark. Stir for 80 minutes, then add the prescribed amount of water while stirring, and continue stirring for 40 minutes after adding water;

[0027] 2) After stirring, filter the liquid obtained in step 1) through a 0.45 μm microporous membrane to obtain a gel transdermal preparation.

Embodiment 2

[0028] Example 2 Pharmacodynamic Study and Skin Irritation Observation of Gel Transdermal Preparation in Treatment of Gouty Arthritis

[0029] 1. Experimental drugs and positive control drugs

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PUM

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Abstract

The invention belongs to the field of medicines, and particularly relates to a gel transdermal preparation for treating gouty arthritis and a preparation method thereof. Effective components of the gel transdermal preparation comprise quercetin and sennoside B; the weight parts of the quercetin and the sennoside B are respectively 122-140 and 1-3. The gel transdermal preparation disclosed by the invention has a good therapeutical effect on the gouty arthritis, and is high in safety.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a gel transdermal preparation for treating gouty arthritis and a preparation method thereof. Background technique [0002] Gout is an immune inflammatory disease caused by hyperuricemia and deposition of urate crystals in joints and surrounding soft tissues caused by purine metabolism disorders in the body. , hyperlipidemia, arteriosclerosis, diabetes and insulin resistance are closely related. Gouty arthritis is the most common first presentation of gout. The disease has an acute onset, and the patient's joints are severely torn and bitten like pain. [0003] The pathogenesis of gouty arthritis is not yet clear, it may be related to genetic factors or diet, drugs, etc. The following factors can often promote the sudden onset of gouty arthritis: such as drinking, intake of a large amount of high-fat and high-protein food, surgery, mental illness Trauma, infection, excessive...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/352A61K31/704A61K9/06A61P19/06
CPCA61K9/0014A61K9/06A61K31/352A61K31/704A61K2300/00
Inventor 刘敬波李艳吴海云
Owner 山东肽莱生物制药有限公司