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Polymer material microfluidic chip

A technology of microfluidic chip and flow, which is applied in the direction of laboratory containers, coatings, chemical instruments and methods, etc., can solve the problems of hydroxyl damage, unsuitability for large-scale production of microfluidic chips, low efficiency, etc., and achieve Rapid preparation and mass production, realization of preparation and mass production, uniform and reliable effect

Active Publication Date: 2020-10-02
北京保利微芯科技有限公司
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  • Abstract
  • Description
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Problems solved by technology

[0003] There are two traditional surface modification methods: the plasma treatment method can treat the surface of the microfluidic chip into hydroxyl groups, so it can achieve the effect of hydrophobic treatment, but the exposed hydroxyl groups will be quickly destroyed by charges and dust in the air. Therefore, the treated surface can only maintain stable performance for a few hours to a day; another method is to pour the liquid used for surface modification into the flow channel of the microfluidic chip, and after the given reaction conditions and reaction time , and then use compressed gas to blow out the reacted liquid. Although this method can change the surface of the microfluidic chip to be hydrophilic or hydrophobic, it can only be processed one by one. The efficiency is low and it is not suitable for microfluidics. Mass production of fluidic chips

Method used

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  • Polymer material microfluidic chip
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1: Preparation of polycarbonate hydrophilic microfluidic chip

[0028] Such as figure 1 As shown, silicon oxide was sputtered on the surface of polycarbonate microfluidic chip to achieve stable hydrophilic modification. The polycarbonate microfluidic chip is prepared by the following steps:

[0029] Step 1: Use 0.3 Pa Argon and 0.1 Pa Oxygen as the environment, and 20 watts as the sputtering power, use Argon to bombard the surface of the silicon target, so that the silicon atoms are detached from the target surface and sputtered onto the surface of the polymer microfluidic chip , and under the action of an oxygen atmosphere, a uniform silicon oxide film with a thickness of 30nm is formed. Scanning electron micrographs of the sputtered microfluidic chip surface as shown in figure 2 shown.

[0030] Step 2: Use an ultrasonic cleaner to clean with acetone, ethanol and deionized water for 10 minutes each, and blow dry with compressed nitrogen.

[0031] figure...

Embodiment 2

[0033] Example 2: Preparation of polycarbonate hydrophobic microfluidic chip

[0034] In the second embodiment of the present invention, silicon oxide is sputtered on the surface of the polycarbonate microfluidic chip, and self-assembled with trichlorosilane molecules to realize stable hydrophobic modification. The water contact angle after hydrophobic modification is 115 degrees.

[0035] Steps 1 to 2 of the preparation of the polycarbonate hydrophobic microfluidic chip are the same as those in the first embodiment.

[0036] Step 3: Soak the cleaned microfluidic chip in 10% hydrogen peroxide solution for 10 minutes.

[0037] Step 4: Dissolving trichlorosilane in isooctane, putting the surface with silicon oxide into it, and soaking for 1 hour to form a silane self-assembly layer.

[0038] Step 5: Use an ultrasonic cleaner to clean with isopropanol and deionized water for 10 minutes each, and blow dry with compressed nitrogen.

[0039] Such as Figure 4 As shown, after the...

Embodiment 3

[0042] Example 3: Generation of water-in-oil microdroplets on a polycarbonate hydrophobic microfluidic chip

[0043] The hydrophobically modified droplet microfluidic chip and the hose used for sample injection were bonded with epoxy resin, and the flow rate of the oil phase (n-hexane) was set to 1.2 mL / h, and the flow rate of the water phase (bright blue solution) was 1.2 mL / h. ) flow rate is 0.6mL / h. Such as Figure 7As shown, the hydrophobically modified droplet microfluidic chip can stably and reliably generate microdroplets of uniform size.

[0044] Such as Figure 8 As shown, the coefficient of variation of the diameter of hundreds of micro-droplets generated by the hydrophobically modified droplet microfluidic chip is less than 0.6%. Fluidic modification of surface hydrophilicity and hydrophobicity has strong applicability and reliability in the field of droplet microfluidics.

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Abstract

The invention provides a polymer material micro-fluidic chip, of which the surface is covered with a layer of silicon oxide. The micro-fluidic chip can be used for preparing a polymer chip which can be used for microfluidics for O / W or W / O liquid drops. Compared with conventional micro-fluidic chips, the micro-fluidic chip is suitable for batch preparation and batch production.

Description

technical field [0001] The invention relates to the field of microfluidic chips, in particular to a polymer material microfluidic chip. Background technique [0002] Droplet microfluidic technology has been widely used in biological, chemical and medical analysis. Polymer materials such as polycarbonate, polypropylene, polydimethylsiloxane, etc. are cheap and stable, and are often used to make microfluidic chips. However, droplet microfluidic chips have high requirements for surface hydrophilicity and hydrophobicity. For example, oil-in-water droplet microfluidic chips often require a hydrophilic surface, and water-in-oil droplet microfluidic chips often require a hydrophobic surface. Therefore, the surface of organic polymers often requires surface modification to achieve better functions. [0003] There are two traditional surface modification methods: the plasma treatment method can treat the surface of the microfluidic chip into hydroxyl groups, so it can achieve the e...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01L3/00C08J7/06
CPCB01L3/502707B01L2300/161B01L2300/165C08J7/06C08J2369/00
Inventor 郭培柱吴大林苏辰宇陈辉王博朱修锐王勇斗
Owner 北京保利微芯科技有限公司
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