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Compound suppository for treating hemorrhoids and preparation method of compound suppository

A technology for compound suppositories and hemorrhoids, which is applied in the direction of suppository delivery, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc. It can solve the problem of limited treatment range of traditional Chinese medicine preparations, attenuation of active ingredients of drugs, and inconvenient treatment process, etc. problems, to achieve the effect of avoiding the first-pass effect, quick onset, and promoting microcirculation

Inactive Publication Date: 2018-09-14
JIANGXI JIUHUA PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This traditional Chinese medicine preparation has the functions of clearing heat, reducing swelling, astringent and hemostasis, and is suitable for I and II internal hemorrhoids caused by damp-heat stasis, but the treatment range of this traditional Chinese medicine preparation is limited, and it has no therapeutic effect on simple external hemorrhoids and anal fissures.
[0005] The patent document with the publication number CN102225176A discloses a traditional Chinese medicine composition for treating hemorrhoids. Poria cocos, Cimicifuga, Sophora japonica, Sophora japonica, oral medicines include black plum, flavescens, shegan, gallnut, scorpion, clam, fangbo leaf, torreya, stone fungus, agrimony, citrus aurantium, white silkworm, hemp seed , the composition provided by this invention can effectively treat hemorrhoids, but it needs to be used in combination with fumigation lotion and oral medicine, and the treatment process is inconvenient. At the same time, the oral preparation of traditional Chinese medicine will produce the first-pass effect of the liver, attenuate the active ingredients of the medicine, and the treatment cycle is long

Method used

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  • Compound suppository for treating hemorrhoids and preparation method of compound suppository

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Effect test

Embodiment 1

[0029] The compound suppository for treating hemorrhoids in this example is prepared from the following raw materials: 350 g of hoof shell extract, 90 g of troxerutin, 30 g of senna leaf extract, and 1230 g of polyethylene glycol 4000.

[0030] The preparation method is as follows: (1) weighing the hoof shell extract, troxerutin and senna leaf extract according to the formula, crushing them with a crusher, and passing through a 120-mesh sieve;

[0031] (2) Heat polyethylene glycol 4000 to a molten state, add the drug sieved in step (1), stir for 2 hours, and fully mix;

[0032] (3) When the temperature drops to 56-60°C, pour the mixed drug into a suppository mold coated with liquid paraffin, and let it cool and solidify naturally to obtain a suppository, 1.7g per suppository, sealed and packaged with PVC.

Embodiment 2

[0034] The compound suppository for treating hemorrhoids in this example is prepared from the following raw materials: 330 g of hoof shell extract, 80 g of troxerutin, 60 g of senna leaf extract, and 1230 g of polyethylene glycol 6000.

[0035] The preparation method is as follows: (1) weighing the hoof shell extract, troxerutin and senna leaf extract according to the formula, crushing them with a crusher, and passing through a 120-mesh sieve;

[0036] (2) Heat polyethylene glycol 6000 to a molten state, add the drug sieved in step (1), stir for 2.5 hours, and fully mix;

[0037] (3) When the temperature drops to 54-58°C, pour the mixed drug into a plug mold coated with liquid paraffin, and cool and solidify naturally to obtain a suppository, 2.1g per plug, sealed with PVC.

Embodiment 3

[0039] The compound suppository for treating hemorrhoids in this example is prepared from the following raw materials: 340 g of hoof shell extract, 95 g of troxerutin, 35 g of senna leaf extract, and 1230 g of glyceryl stearate (type 36).

[0040] The preparation method is as follows: (1) weighing the hoof shell extract, troxerutin and senna leaf extract according to the formula, crushing them with a crusher, and passing through a 120-mesh sieve;

[0041] (2) Heating glyceryl stearate to molten state, adding the medicine sieved in step (1), stirring for 3h, and fully mixing;

[0042] (3) When the temperature drops to 56-60°C, pour the mixed drug into a suppository mold coated with liquid paraffin, and let it cool and solidify naturally to obtain a suppository, 1.7g per suppository, sealed and packaged with PVC.

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Abstract

The invention relates to a compound suppository for treating hemorrhoids and a preparation method of the compound suppository. The compound suppository is prepared from medicine powder and accessoriesin a mixed manner according to the proportion of 47:123. The medicine powder comprises, by weight, 65-95 parts of animol toenail extracts, 4-15 parts of troxerutin and 1-5 parts of folium sennae extracts. The compound suppository integrates treatment, fundamental solution and healing according to pathogenesis of the hemorrhoids, pathological change and symptoms caused by the hemorrhoids, the hemorrhoids can be fundamentally treated, and the compound suppository treats the hemorrhoids from both manifestation and root causes of diseases and is free from any toxic and side effects and convenientto use.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a compound suppository for treating hemorrhoids and a preparation method thereof. Background technique [0002] Hemorrhoids are the most common diseases in the human anus. They are clinically common and frequently-occurring diseases, and are lingering and intractable. They are easy to recur after treatment and difficult to eradicate, seriously affecting the quality of life of patients. According to relevant census statistics in some medical departments in 2007, among the 57,297 individuals in the census, there were 33,837 hemorrhoid patients, and the incidence rate was 59%. Among them, the male incidence rate is 53.9%, and the female incidence rate is 67%. The incidence rate of female is higher than that of male. The census also shows that the incidence rate of hemorrhoids in adults is 59.1%, and the older you are, the more patients you suffer f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/482A61K9/02A61K47/10A61P9/14A61K35/36A61K31/7048
CPCA61K9/02A61K31/7048A61K35/36A61K36/482A61K47/10A61P9/14A61K2300/00
Inventor 张俊玮杨华刘中伟
Owner JIANGXI JIUHUA PHARMA
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